The use of botulinum toxin in ophthalmology

Authors

DOI:

https://doi.org/10.56782/pps.253

Keywords:

botulinum toxin, ophthalmology, strabismus, tearing, eyelid spasm

Abstract

Botulinum toxin is an exotoxin produced by the anaerobic bacteria Clostridium botulinum. It is one of the most potent neurotoxins known and used in medicine. Its versatile use covers various fields of medicine, including ophthalmology. Botulinum toxin is widely used in ophthalmology for both therapeutic and aesthetic purposes. Thanks to its mechanism of action of inhibiting the release of acetylcholine, it leads to muscle paresis and inhibition of the function of the exocrine glands. This makes it effective in treating such conditions as, for example, strabismus, nystagmus, epiphora, and eyelid spasm. On the other hand, in aesthetic medicine it is used to reduce "crow's feet". The properties of botulinum toxin make it a beneficial therapeutic tool used in ophthalmology. Studies show its effectiveness in treating various ocular muscle dysfunctions and excessive tearing. The purpose of this article is to discuss the current indications and potential uses of botulinum toxin in ophthalmology.

Downloads

Download data is not yet available.

References

1. Sobel, J. Botulism. Clin. Infect. Dis. 2005, 41, 1167-1173. DOI: 10.1086/444507 DOI: https://doi.org/10.1086/444507

2. Wan, M.J.; AlShaker, S.; Hunter, D G. Use of Botulinum Toxin in Ophthalmology. Handb. Exp. Pharmacol. 2021, 263, 147-160. DOI: 10.1007/164_2019_325 DOI: https://doi.org/10.1007/164_2019_325

3. Dressler, D.; Adib Saberi, F. Botulinum Toxin: Mechanisms of Action. Eur. Neurol. 2005, 53, 3–9. DOI: 10.1159/000083259 DOI: https://doi.org/10.1159/000083259

4. Nigam, P. K.; Nigam, A. Botulinum toxin. Indian J. Dermatol. 2010, 55, pp. 8–14. DOI: 10.4103/0019-5154.60343 DOI: https://doi.org/10.4103/0019-5154.60343

5. Dutta, S.R.; Passi, D.; Singh, M.; Singh, P.; Sharma, S.; Sharma, A. Botulinum toxin the poison that heals: A brief review. Natl. J. Maxillofac. Surg. 2016, 7, 10–16. DOI: 10.4103/0975-5950.196133 DOI: https://doi.org/10.4103/0975-5950.196133

6. Lam, K.H.; Jin, R. Architecture of the botulinum neurotoxin complex: a molecular machine for protection and delivery. Curr. Opin. Struct. Biol. 2015, 31, 89–95. DOI: 10.1016/j.sbi.2015.03.013 DOI: https://doi.org/10.1016/j.sbi.2015.03.013

7. Montal, M. Botulinum neurotoxin: a marvel of protein design. Annu. Rev. Biochem. 2010, 79, 591-617. DOI: 10.1146/annurev.biochem.051908.125345 DOI: https://doi.org/10.1146/annurev.biochem.051908.125345

8. Breidenbach, M.A.; Brunger, A.T. Substrate recognition strategy for botulinum neurotoxin serotype A. Nature. 2004, 432, 925-929. DOI: 10.1038/nature03123 DOI: https://doi.org/10.1038/nature03123

9. Dressler, D.; Saberi, F.A.; Barbosa, E.R. Botulinum toxin: mechanisms of action. Arq. Neuropsiquiatri. 2005, 63, 180-185. DOI: 10.1590/s0004-282x2005000100035 DOI: https://doi.org/10.1590/S0004-282X2005000100035

10. Dutton, J.J.; Fowler, A.M. Botulinum toxin in ophthalmology. Surv. Ophthalmol. 2007, 52, 13-31. DOI: 10.1016/j.survophthal.2006.10.003 DOI: https://doi.org/10.1016/j.survophthal.2006.10.003

11. Gregory, S.; Acharya, K.R. A Comprehensive Structural Analysis of Clostridium botulinum Neurotoxin A Cell-Binding Domain from Different Subtypes. Toxins (Basel). 2023, 15, Art. No: 92. DOI: 10.3390/toxins15020092 DOI: https://doi.org/10.3390/toxins15020092

12. Montecucco, C.; Molgó, J. Botulinum neurotoxins: revival of an old killer. Curr. Opin. Pharmacol. 2005, 5, 274-279. DOI: 10.1016/j.coph.2004.12.006 DOI: https://doi.org/10.1016/j.coph.2004.12.006

13. Simpson, L. L. Identification of the major steps in botulinum toxin action. Ann. Rev. Pharmacol. Toxicol. 2004, 44, 167-193. DOI: 10.1146/annurev.pharmtox.44.101802.121554 DOI: https://doi.org/10.1146/annurev.pharmtox.44.101802.121554

14. Leszczynska, A.; Nowicka, D.; Pillunat, L.E.; Szepietowski, J.C. Five decades of the use of botulinum toxin in ophthalmology. Indian J. Ophthalmol. 2024, 72, 789-795. DOI: 10.4103/IJO.IJO_1030_23 DOI: https://doi.org/10.4103/IJO.IJO_1030_23

15. Binenbaum, G.; Chang, M.Y.; Heidary, G.; Morrison, D.G.; Trivedi, R.H.; Galvin, J.A.; Pineles, S.L. Botulinum Toxin Injection for the Treatment of Strabismus: A Report by the American Academy of Ophtalmology. Ophtalmology 2021, 128, 1766-1776 DOI: 10.1016/j.ophtha.2021.05.009 DOI: https://doi.org/10.1016/j.ophtha.2021.05.009

16. Bort-Martí, A.R.; Rowe, F.J.; Ruiz Sifre, L.; et al. Botulinum toxin for the treatment of strabismus. Cochrane Database Syst. Rev. 2023, 3, Art. No: CD006499. DOI: 10.1002/14651858.CD006499.pub5 DOI: https://doi.org/10.1002/14651858.CD006499.pub5

17. Medicine after the diploma. Available online: https://podyplomie.pl/okulistyka/38666,ortoptyka-zastosowanie-toksyny-botulinowej-i-bupiwakainy-w-leczeniu-roznych-typow-zeza?page=4&srsltid=AfmBOoru2GCUBOa_CRUVfqVqCHgmhl-vByJx4T8btQkVyFWN9TyGLf8j (accessed 07.07.2024)

18. Sabetti, L.; Guetti, F.; Pomanti, V.; Murano, G. Botulinum Toxin for the Treatment of Nystagmus Associated with Exotropia. Open J. Ophthalmol. 2022, 12, Art. No: 4. DOI: 10.4236/ojoph.2022.124036 DOI: https://doi.org/10.4236/ojoph.2022.124036

19. Venturi, N.; Adams, G.; Theodorou, M. The Use of Botulinum Toxin in a Case of Acquired Periodic Alternating Nystagmus. Br. Ir. Orthopt. J. 2021, 17, 85-90. DOI: 10.22599/bioj.170 DOI: https://doi.org/10.22599/bioj.170

20. Başar, E.; Arıcı, C. Use of Botulinum Neurotoxin in Ophthalmology. Turk. J. Ophthalmol. 2016, 46, 282–290. DOI: 10.4274/tjo.57701 DOI: https://doi.org/10.4274/tjo.57701

21. Schinwelski, M. Blepharospasm – from diagnosis to proper treatment. OphthaTherapy. 2019, 6(1), 43-50. DOI: 10.24292/01.OT.300319.07 DOI: https://doi.org/10.24292/01.OT.300319.07

22. Hellman, A.; Torres-Russotto, D. Botulinum toxin in the management of blepharospasm: current evidence and recent developments. Ther. Adv. Neurol. Disord. 2015, 8, 82–91. DOI: 10.1177/1756285614557475 DOI: https://doi.org/10.1177/1756285614557475

23. Scott, A.B.; Fahn, S.; Brin, M.F. Treatment of strabismus and blepharospasm with Botox (onabotulinumtoxinA): Development, insights, and impact. Medicine (Baltimore). 2023, 102, Art. No: e32374. DOI: 10.1097/MD.0000000000032374 DOI: https://doi.org/10.1097/MD.0000000000032374

24. Dressler, D.; Pan, L.; Saberi, F.A. Antibody-induced failure of botulinum toxin therapy: re-start with low-antigenicity drugs offers a new treatment opportunity. J. Neural. Transm. (Vienna). 2018, 125, 1481-1486. DOI: 10.1007/s00702-018-1911-3 DOI: https://doi.org/10.1007/s00702-018-1911-3

25. Alsuhaibani, A.H.; Eid, S.A. Botulinum toxin injection and tear production. Curr. Opin. Ophthalmol. 2018, 29, 428-433. DOI: 10.1097/ICU.0000000000000506 DOI: https://doi.org/10.1097/ICU.0000000000000506

26. Pattanayak, S.; Sharma, P.K.; Samikhya, S.; et al. Transconjunctival botulinum toxin injection into the lacrimal gland in crocodile tears syndrome. Indian J. Ophthalmol. 2022, 70, 1339-1342. DOI: 10.4103/ijo.IJO_2909_21 DOI: https://doi.org/10.4103/ijo.IJO_2909_21

27. Lima-Fontes, M.; Leuzinger-Dias, M.; Falcão-Reis, F.; Sousa, C. Injection of Botulinum Toxin A in the Lacrimal Gland for Treatment of Epiphora in Crocodile Tears Syndrome – A Case Report. Int. Med. Case Rep. J. 2022, 15, 537–542. DOI: 10.2147/IMCRJ.S379024 DOI: https://doi.org/10.2147/IMCRJ.S379024

28. Deka, A.; Saikia, S.P. Lower lid entropion correction with botulinum toxin injection. Oman J. Ophthalmol. 2010, 3, 158–159. DOI: 10.4103/0974-620X.71909 DOI: https://doi.org/10.4103/0974-620X.71909

29. Steel, D.H.; Hoh, H.B.; Harrad, R.A.; Collins, C.R. Botulinum toxin for the temporary treatment of involutional lower lid entropion: a clinical and morphological study. Eye (Lond). 1997, 11, 472-475. DOI: 10.1038/eye.1997.128 DOI: https://doi.org/10.1038/eye.1997.128

30. Carruthers, J.; Stubbs, H.A. Botulinum Toxin for Benign Essential Blepharospasm, Hemifacial Spasm and Age-Related Lower Eyelid Entropion. Can. J. Neurol. Sci. 1987, 14, 42 – 45. DOI: 10.1017/s0317167100026159 DOI: https://doi.org/10.1017/S0317167100026159

31. Rita, M.R.H.; Deepa, M.; Gitanjali, V.C.; Tinu, S.R.; et al. Lagophthalmos: An etiological lookout to frame the decision for management. Indian J. Ophthalmol. 2022, 70, 3077–3082. DOI: 10.4103/ijo.IJO_3017_21 DOI: https://doi.org/10.4103/ijo.IJO_3017_21

32. Medicine after the diploma. Available online: https://podyplomie.pl/okulistyka/33990,mozliwosci-leczenia-niedomykalnosci-szpary-powiekowej-spowodowanej-utrwalonym-porazeniem-nerwu?srsltid=AfmBOoqxhV-w6y9wU2Y3YjEF9pysSSbWF7DQdra8k5dKA0LtRbkWg2Qf (accessed 10.07.2024).

33. Yücel, O.E.; Artürk, N. Botulinum toxin-A-induced protective ptosis in the treatment of lagophthalmos associated with facial paralysis. Ophthalmic Plast. Reconstr. Surg. 2012, 28, 256-260. DOI: 10.1097/IOP.0b013e31824ee702 DOI: https://doi.org/10.1097/IOP.0b013e31824ee702

34. Siastała, P. Methods of revitalization of the eye area with botulinum toxin from the point of view of an ophthalmologist. Aesthet. Cosmetol. 2019, 8(1), 111-115.

35. Naik, M.N.; Soparkar, Ch.Ns.; Murthy, R.; Honavar, S.G. Botulinum Toxin in Ophthalmic Plastic Surgery. Indian J. Ophthalmol. 2005, 53, 279-288. DOI: 10.4103/0301-4738.18915 DOI: https://doi.org/10.4103/0301-4738.18915

36. Carruthers, A.; Carruthers, J.; De Boulle, K. Treatment of crow’s feet lines and forehead lines with Botox (onabotulinumtoxinA): Development, insights, and impact. Medicine (Baltimore). 2023, 102, Art. No: e32496. DOI: 10.1097/MD.0000000000032496 DOI: https://doi.org/10.1097/MD.0000000000032496

Downloads

Published

2024-12-13

Issue

Section

Articles

How to Cite

The use of botulinum toxin in ophthalmology. (2024). Prospects in Pharmaceutical Sciences, 22(4), 93-98. https://doi.org/10.56782/pps.253