POSZUKIWANIE NASTĘPCÓW PROTAMINY: SKUTECZNE I BEZPIECZNE HAMOWANIE KRWAWIENIA WYWOŁANEGO PODANIEM POZAJELITOWYCH ŚRODKÓW PRZECIWKRZEPLIWYCH

Emilia Sokołowska; Andrzej Mogielnicki

doi:10.56782/pps.102

Published : 2016-05-25

Vol. 14 No. 2 (2016)

SEARCH FOR PROTAMINE REPLACEMENTS: EFFICACIOUS AND SAFE INHIBITION OF BLEEDING INDUCED BY PARENTERAL ANTICOAGULANTS

Emilia Sokołowska

Andrzej Mogielnicki

DOI: https://doi.org/10.56782/pps.102

Abstract

Unfractionated heparin is used in medicine as an anticoagulant to prevent blood clotting. In life-threatening emergencies when fast reversal of the anticoagulant action of heparin is necessary, protamine – an agent approved in 1939 – is available as an antidote. The biological origin of protamine, which is isolated from salmon sperm, is probably responsible for its considerable toxicity, which manifests itself as arterial hypotension, catastrophic pulmonary vasoconstriction or severe, sometimes lethal, anaphylactic reaction. Consequently, safer alternatives have been sought for many years. The most promising antidote currently in an advanced stage of development is andexanet alfa. In the present review, we discuss the major deleterious effects of protamine and list agents, presently in the research phase, with the potential to neutralize the action of parenteral anticoagulants.

Keywords:

heparin, protamine, antidote

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Sokołowska, E., & Mogielnicki, A. (2016). SEARCH FOR PROTAMINE REPLACEMENTS: EFFICACIOUS AND SAFE INHIBITION OF BLEEDING INDUCED BY PARENTERAL ANTICOAGULANTS. Prospects in Pharmaceutical Sciences, 14(2), 7–16. https://doi.org/10.56782/pps.102

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Emilia Sokołowska

emiliasokolowska.umwb@gmail.com

Bio Statement (e.g., department and rank)

autorka korespondująca, tel: +48 506 361 821

Andrzej Mogielnicki

Affiliation:

Zakład Farmakodynamiki, Uniwersytet Medyczny w Białymstoku, Mickiewicza 2c, 15-089 Białystok Poland