Lycium barbarum fruits –phytochemistry and activity of goji berries – from tradition to clinical studies

Authors

  • Monika Czerwińska Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland; Centre for Preclinical Research, Medical University of Warsaw, 02-097 Warsaw, Poland
  • Marta Kuśnierek Student Scientific Association, Department of Pharmaceutical Biology, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland

DOI:

https://doi.org/10.56782/pps.197

Keywords:

Lycium barbarum, goji, polysaccharides

Abstract

The barbary wolfberry fruit (Lycium barbarum L.) has been used in traditional Chinese medicine (TCM) for centuries as an anti-aging, anti-fatigue, immune-supporting, and soothing agent for many
age-related, mainly metabolic, oxidative, and inflammatory diseases. Edible fruits of L. barbarum,
which are commercially available, are known as goji berries. Several studies suggest the therapeutic significance of this plant material as a dietary supplement or functional food. This literature review was aimed at gathering and systematizing the existing knowledge about L. barbarum fruits and was also an attempt to explain scientifically the wide application of these fruits in TCM. The literature review was made mainly using Scopus and Google Scholar databases. Numerous in vitro and in vivo studies indicate the effectiveness of L. barbarum fruit extracts and their preparations in many diseases, especially of oxidative, metabolic, and inflammatory origin. Polysaccharides, carotenoids, and polyphenols prevailing in fruits are reported to be responsible for such properties. This review may provide a theoretical basis for further studying and extending the applications of the barbary wolfberry in the fields of medicine and dietetics.

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References

Seneta, W., Dendrologia; Dział Wydawnictw SGGW: Warszawa, 1967.

Yao, R.; Heinrich, M.; Weckerle, C. S. The genus Lycium as food and medicine: a botanical, ethnobotanical and historical review. J. Ethnopharmacol. 2018, 212, 50-66. DOI: 10.1016/j.jep.2017.10.010. DOI: https://doi.org/10.1016/j.jep.2017.10.010

Schmiedel, D. A.-V. D. R., 2019. European Pharmacopoeia, 10th Edition 2019. Deutscher Apotheker Verlag.

Farmakopea Polska XII, 2020. Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych, Produktów Biobójczych, Warszawa.

Chang, R. C. C.; So, K. F., Lycium barbarum and human health; Springer Netherlands, 2015. DOI: https://doi.org/10.1007/978-94-017-9658-3

Lim, T. K., Edible medicinal and non-medicinal plants: Fruits; Springer Netherlands, 2013. DOI: https://doi.org/10.1007/978-94-007-5628-1

Adamowicz, A., Orgelbrand, S., Encyklopedia powszechna; Wydawn. Artystyczne i Filmowe, 1865.

Miejski Ogród Botaniczny w Zabrzu; Available online: https://mob.zabrze.pl/wp-content/uploads/2020/02/lycium_barbarum_l.pdf (accessed on 20.03.2024).

Harsh, M. Tropane alkaloids from Lycium barbarum Linn. in vivo and in vitro. 1989.

Marosz, A. Owoce jagody goji (Lycium barbarum i Lycium chinense) – nowe możliwości dla ogrodnictwa czy zagrożenie dla konsumentów? Ann. Hortic. 2017, 27, 19-30. DOI: 10.24326/ah.2017.1.3. DOI: https://doi.org/10.24326/ah.2017.1.3

Kokotkiewicz, A.; Migas, P.; Stefanowicz, J.; Luczkiewicz, M.; Krauze-Baranowska, M. Densitometric TLC analysis for the control of tropane and steroidal alkaloids in Lycium barbarum. Food Chem. 2017, 221, 535-540. DOI: 10.1016/j.foodchem.2016.11.142. DOI: https://doi.org/10.1016/j.foodchem.2016.11.142

Haratym, W.; Weryszko-Chmielewska, E.; Żuraw, B.; Tietze, M. Krzewy o właściwościach trujących. Alergoprofil 2013, 9(4), 26-34.

Kwok, S. S.; Bu, Y.; Lo, A. C.; Chan, T. C.; So, K. F.; Lai, J. S.; Shih, K. C. A systematic review of potential therapeutic use of Lycium barbarum polysaccharides in disease. Biomed. Res. Int. 2019, 2019, 4615745. DOI: 10.1155/2019/4615745. DOI: https://doi.org/10.1155/2019/4615745

Gao, Y.; Wei, Y.; Wang, Y.; Gao, F.; Chen, Z. Lycium barbarum: a traditional Chinese herb and a promising anti-aging agent. Aging Dis. 2017, 8(6), 778-791. DOI: 10.14336/ad.2017.0725. DOI: https://doi.org/10.14336/AD.2017.0725

Ni, J.; Au, M.; Kong, H.; Wang, X.; Wen, C. Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review. BMC Complement. Med. Ther. 2021, 21(1), 212. DOI: 10.1186/s12906-021-03385-0. DOI: https://doi.org/10.1186/s12906-021-03385-0

Yang, C.; Zhao, Q.; Li, S.; Pu, L.; Yu, L.; Liu, Y.; Lai, X. Effects of Lycium barbarum L. polysaccharides on vascular retinopathy: an insight review. Molecules 2022, 27(17). DOI: 10.3390/molecules27175628. DOI: https://doi.org/10.3390/molecules27175628

Xing, X.; Liu, F.; Xiao, J.; So, K. F. Neuro-protective mechanisms of Lycium barbarum. Neuromolecular Med. 2016, 18(3), 253-263. DOI: 10.1007/s12017-016-8393-y. DOI: https://doi.org/10.1007/s12017-016-8393-y

Huang, Y.; Zhang, X.; Chen, L.; Ren, B. X.; Tang, F. R. Lycium barbarum ameliorates neural damage induced by experimental ischemic stroke and radiation exposure. Front Biosci (Landmark Ed) 2023, 28(2), 38. DOI: 10.31083/j.fbl2802038. DOI: https://doi.org/10.31083/j.fbl2802038

Li, J.; Guo, H.; Dong, Y.; Yuan, S.; Wei, X.; Zhang, Y.; Dong, L.; Wang, F.; Bai, T.; Yang, Y. Polysaccharides from Chinese herbal medicine: a review on the hepatoprotective and molecular mechanism. Chin. J. Nat. Med. 2024, 22(1), 4-14. DOI: 10.1016/s1875-5364(24)60558-3. DOI: https://doi.org/10.1016/S1875-5364(24)60558-3

Zhou, B.; Xia, H.; Yang, L.; Wang, S.; Sun, G. The effect of Lycium barbarum polysaccharide on the glucose and lipid metabolism: a systematic review and meta-analysis. J. Am. Nutr. Assoc. 2022, 41(6), 618-626. DOI: 10.1080/07315724.2021.1925996. DOI: https://doi.org/10.1080/07315724.2021.1925996

Liu, H.; Cui, B.; Zhang, Z. Mechanism of glycometabolism regulation by bioactive compounds from the fruits of Lycium barbarum: a review. Food Res. Int. 2022, 159, 111408. DOI: 10.1016/j.foodres.2022.111408. DOI: https://doi.org/10.1016/j.foodres.2022.111408

Teixeira, F.; Silva, A. M.; Delerue-Matos, C.; Rodrigues, F. Lycium barbarum berries (Solanaceae) as source of bioactive compounds for healthy purposes: a review. Int. J. Mol. Sci. 2023, 24(5), 4777. DOI: 10.3390/ijms24054777. DOI: https://doi.org/10.3390/ijms24054777

Cao, C.; Wang, Z.; Gong, G.; Huang, W.; Huang, L.; Song, S.; Zhu, B. Effects of Lycium barbarum polysaccharides on immunity and metabolic syndrome associated with the modulation of gut microbiota: a review. Foods 2022, 11(20). DOI: 10.3390/foods11203177. DOI: https://doi.org/10.3390/foods11203177

Xiao, Z.; Deng, Q.; Zhou, W.; Zhang, Y. Immune activities of polysaccharides isolated from Lycium barbarum L. What do we know so far? Pharmacol. Therapeut. 2022, 229, 107921. DOI: 10.1016/j.pharmthera.2021.107921. DOI: https://doi.org/10.1016/j.pharmthera.2021.107921

Tian, X.; Liang, T.; Liu, Y.; Ding, G.; Zhang, F.; Ma, Z. Extraction, structural characterization, and biological functions of Lycium barbarum polysaccharides: a review. Biomolecules 2019, 9(9). DOI: 10.3390/biom9090389. DOI: https://doi.org/10.3390/biom9090389

Yu, Z.; Xia, M.; Lan, J.; Yang, L.; Wang, Z.; Wang, R.; Tao, H.; Shi, Y. A comprehensive review on the ethnobotany, phytochemistry, pharmacology and quality control of the genus Lycium in China. Food Funct. 2023, 14(7), 2998-3025. DOI: 10.1039/d2fo03791b. DOI: https://doi.org/10.1039/D2FO03791B

MapChart; Available online: https://www.mapchart.net/ (accessed on 20.03.2024).

Amagase, H.; Farnsworth, N. R. A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Int. Food Res. J. 2011, 44(7), 1702-1717. DOI: 10.1016/j.foodres.2011.03.027. DOI: https://doi.org/10.1016/j.foodres.2011.03.027

Healthcare, T., PDR for herbal medicines; Montvale: Thomson Healthcare, 2004.

Potterat, O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med 2010, 76(1), 7-19. DOI: 10.1055/s-0029-1186218. DOI: https://doi.org/10.1055/s-0029-1186218

Yao, R.; Heinrich, M.; Zou, Y.; Reich, E.; Zhang, X.; Chen, Y.; Weckerle, C. S. Quality variation of goji (Fruits of Lycium spp.) in China: a comparative morphological and metabolomic analysis. Front. Pharmacol. 2018, 9. DOI: 10.3389/fphar.2018.00151. DOI: https://doi.org/10.3389/fphar.2018.00151

Jin, M.; Huang, Q.; Zhao, K.; Shang, P. Biological activities and potential health benefit effects of polysaccharides isolated from Lycium barbarum L. Int. J. Biol. Macromol. 2013, 54, 16-23. DOI: 10.1016/j.ijbiomac.2012.11.023. DOI: https://doi.org/10.1016/j.ijbiomac.2012.11.023

Zhu, M.; Jinggang, M.; ChangSheng, H.; Haiping, X.; Ning, M.; Caijiao, W. Extraction, characterization of polysaccharides from Lycium barbarum and its effect on bone gene expression in rats. Carbohydr. Polym. 2010, 80(3), 672-676. DOI: 10.1016/j.carbpol.2009.11.038. DOI: https://doi.org/10.1016/j.carbpol.2009.11.038

Wu, H. T.; He, X. J.; Hong, Y. K.; Ma, T.; Xu, Y. P.; Li, H. H. Chemical characterization of Lycium barbarum polysaccharides and its inhibition against liver oxidative injury of high-fat mice. Int. J. Biol. Macromol. 2010, 46(5), 540-543. DOI: 10.1016/j.ijbiomac.2010.02.010. DOI: https://doi.org/10.1016/j.ijbiomac.2010.02.010

Ke, M.; Zhang, X.-J.; Han, Z.-H.; Yu, H.-Y.; Lin, Y.; Zhang, W.-G.; Sun, F.-H.; Wang, T.-J. Extraction, purification of Lycium barbarum polysaccharides and bioactivity of purified fraction. Carbohydr. Polym. 2011, 86(1), 136-141. DOI: 10.1016/j.carbpol.2011.04.023. DOI: https://doi.org/10.1016/j.carbpol.2011.04.023

Redgwell, R. J.; Curti, D.; Wang, J.; Dobruchowska, J. M.; Gerwig, G. J.; Kamerling, J. P.; Bucheli, P. Cell wall polysaccharides of Chinese wolfberry (Lycium barbarum): Part 2. Characterisation of arabinogalactan-proteins. Carbohydrate Polymers 2011, 84(3), 1075-1083. DOI: 10.1016/j.carbpol.2010.12.071. DOI: https://doi.org/10.1016/j.carbpol.2010.12.071

Redgwell, R. J.; Curti, D.; Wang, J.; Dobruchowska, J. M.; Gerwig, G. J.; Kamerling, J. P.; Bucheli, P. Cell wall polysaccharides of Chinese wolfberry (Lycium barbarum): Part 1. Characterisation of soluble and insoluble polymer fractions. Carbohydr. Polym. 2011, 84(4), 1344-1349. DOI: 10.1016/j.carbpol.2011.01.032. DOI: https://doi.org/10.1016/j.carbpol.2011.01.032

Qian, D.; Zhao, Y.; Yang, G.; Huang, L. Systematic review of chemical constituents in the genus Lycium (Solanaceae). Molecules 2017, 22(6), 911. DOI: 10.3390/molecules22060911. DOI: https://doi.org/10.3390/molecules22060911

Wu, D.-T.; Guo, H.; Lin, S.; Lam, S.-C.; Zhao, L.; Lin, D.-R.; Qin, W. Review of the structural characterization, quality evaluation, and industrial application of Lycium barbarum polysaccharides. Trends Food Sci. Technol. 2018, 79, 171-183. DOI: 10.1016/j.tifs.2018.07.016. DOI: https://doi.org/10.1016/j.tifs.2018.07.016

Wojdyło, A.; Nowicka, P.; Bąbelewski, P. Phenolic and carotenoid profile of new goji cultivars and their anti-hyperglycemic, anti-aging and antioxidant properties. J. Funct. Foods 2018, 48, 632-642. DOI: 10.1016/j.jff.2018.07.061. DOI: https://doi.org/10.1016/j.jff.2018.07.061

Inbaraj, B. S.; Lu, H.; Hung, C. F.; Wu, W. B.; Lin, C. L.; Chen, B. H. Determination of carotenoids and their esters in fruits of Lycium barbarum Linnaeus by HPLC–DAD–APCI–MS. J. Pharm. Biomed. Anal. 2008, 47(4), 812-818. DOI: 10.1016/j.jpba.2008.04.001. DOI: https://doi.org/10.1016/j.jpba.2008.04.001

Wang, C. C.; Chang, S. C.; Inbaraj, B. S.; Chen, B. H. Isolation of carotenoids, flavonoids and polysaccharides from Lycium barbarum L. and evaluation of antioxidant activity. Food Chem. 2010, 120(1), 184-192. DOI: 10.1016/j.foodchem.2009.10.005. DOI: https://doi.org/10.1016/j.foodchem.2009.10.005

Pires, T. C. S. P.; Dias, M. I.; Barros, L.; Calhelha, R. C.; Alves, M. J.; Santos-Buelga, C.; Ferreira, I. C. F. R. Phenolic compounds profile, nutritional compounds and bioactive properties of Lycium barbarum L.: A comparative study with stems and fruits. Ind. Crops Prod. 2018, 122, 574-581. DOI: 10.1016/j.indcrop.2018.06.046. DOI: https://doi.org/10.1016/j.indcrop.2018.06.046

Tripodo, G.; Ibáñez, E.; Cifuentes, A.; Gilbert-López, B.; Fanali, C. Optimization of pressurized liquid extraction by response surface methodology of goji berry (Lycium barbarum L.) phenolic bioactive compounds. Electrophoresis 2018, 39(13), 1673-1682. DOI: 10.1002/elps.201700448. DOI: https://doi.org/10.1002/elps.201700448

Toyoda-Ono, Y.; Maeda, M.; Nakao, M.; Yoshimura, M.; Sugiura-Tomimori, N.; Fukami, H. 2-O-(β-d-Glucopyranosyl)ascorbic acid, a novel ascorbic acid analogue isolated from Lycium fruit. J. Agric. Food Chem. 2004, 52(7), 2092-2096. DOI: 10.1021/jf035445w. DOI: https://doi.org/10.1021/jf035445w

Guo, M.; Shi, T.; Duan, Y.; Zhu, J.; Li, J.; Cao, Y. Investigation of amino acids in wolfberry fruit (Lycium barbarum) by solid-phase extraction and liquid chromatography with precolumn derivatization. J. Food Compos. Anal. 2015, 42, 84-90. DOI: 10.1016/j.jfca.2015.03.004. DOI: https://doi.org/10.1016/j.jfca.2015.03.004

Yao, X.; Peng, Y.; Xu, L.-J.; Li, L.; Wu, Q.-L.; Xiao, P.-G. Phytochemical and biological studies of Lycium medicinal plants. Chem. Biodiversity 2011, 8(6), 976-1010. DOI: 10.1002/cbdv.201000018. DOI: https://doi.org/10.1002/cbdv.201000018

Zhou, Z. Q.; Fan, H. X.; He, R. R.; Xiao, J.; Tsoi, B.; Lan, K. H.; Kurihara, H.; So, K. F.; Yao, X. S.; Gao, H. Lycibarbarspermidines A-O, new dicaffeoylspermidine derivatives from wolfberry, with activities against Alzheimer's disease and oxidation. J. Agric. Food Chem. 2016, 64(11), 2223-2237. DOI: 10.1021/acs.jafc.5b05274. DOI: https://doi.org/10.1021/acs.jafc.5b05274

Gao, Z.; Ali, Z.; Khan, I. A. Glycerogalactolipids from the fruit of Lycium barbarum. Phytochemistry 2008, 69(16), 2856-2861. DOI: 10.1016/j.phytochem.2008.09.002. DOI: https://doi.org/10.1016/j.phytochem.2008.09.002

Gao, K.; Ma, D.; Cheng, Y.; Tian, X.; Lu, Y.; Du, X.; Tang, H.; Chen, J. Three new dimers and two monomers of phenolic amides from the fruits of Lycium barbarum and their antioxidant activities. J. Agric. Food Chem. 2015, 63(4), 1067-1075. DOI: 10.1021/jf5049222. DOI: https://doi.org/10.1021/jf5049222

Wang, K.; Sasaki, T.; Li, W.; Li, Q.; Wang, Y.; Asada, Y.; Kato, H.; Koike, K. Two novel steroidal alkaloid glycosides from the seeds of Lycium barbarum. Chem. Biodiv. 2011, 8(12), 2277-2284. DOI: 10.1002/cbdv.201000293. DOI: https://doi.org/10.1002/cbdv.201000293

Masci, A.; Carradori, S.; Casadei, M. A.; Paolicelli, P.; Petralito, S.; Ragno, R.; Cesa, S. Lycium barbarum polysaccharides: extraction, purification, structural characterisation and evidence about hypoglycaemic and hypolipidaemic effects. A review. Food Chem. 2018, 254, 377-389. DOI: 10.1016/j.foodchem.2018.01.176. DOI: https://doi.org/10.1016/j.foodchem.2018.01.176

Wang, W.-F.; Yang, J.-L.; Shi, Y.-P. Quality evaluation of six bioactive constituents in goji berry based on capillary electrophoresis field amplified sample stacking. Electrophoresis 2018, 39(16), 2117-2124. DOI: 10.1002/elps.201800102. DOI: https://doi.org/10.1002/elps.201800102

Zhou, Z.-Q.; Xiao, J.; Fan, H.-X.; Yu, Y.; He, R.-R.; Feng, X.-L.; Kurihara, H.; So, K.-F.; Yao, X.-S.; Gao, H. Polyphenols from wolfberry and their bioactivities. Food Chem. 2017, 214, 644-654. DOI: 10.1016/j.foodchem.2016.07.105. DOI: https://doi.org/10.1016/j.foodchem.2016.07.105

Inbaraj, B. S.; Lu, H.; Kao, T. H.; Chen, B. H. Simultaneous determination of phenolic acids and flavonoids in Lycium barbarum Linnaeus by HPLC–DAD–ESI-MS. J. Pharm. Biomed. Anal. 2010, 51(3), 549-556. DOI: 10.1016/j.jpba.2009.09.006. DOI: https://doi.org/10.1016/j.jpba.2009.09.006

Rodrigues Sá, R.; da Cruz Caldas, J.; de Andrade Santana, D.; Vieira Lopes, M.; dos Santos, W. N. L.; Graças Andrade Korn, M.; de Freitas Santos Júnior, A. Multielementar/centesimal composition and determination of bioactive phenolics in dried fruits and capsules containing goji berries (Lycium barbarum L.). Food Chem. 2019, 273, 15-23. DOI: 10.1016/j.foodchem.2018.05.124. DOI: https://doi.org/10.1016/j.foodchem.2018.05.124

Kulczyński, B.; Gramza-Michałowska, A. Goji berry (Lycium barbarum): composition and health effects – a review. Pol. J. Food Nutr. Sci. 2016, 66(2), 67-75. DOI: 10.1515/pjfns-2015-0040. DOI: https://doi.org/10.1515/pjfns-2015-0040

Montesano, D.; Rocchetti, G.; Cossignani, L.; Lucini, L.; Simonetti, M. S.; Blasia, F. Italian Lycium barbarum L. berry: chemical characterization and nutraceutical value. Nat. Prod. Commun. 2018, 13(9), 1934578X1801300913. DOI: 10.1177/1934578x1801300913. DOI: https://doi.org/10.1177/1934578X1801300913

Taulavuori, K.; Julkunen-Tiitto, R.; Hyöky, V.; Taulavuori, E. Blue Mood for Superfood. Nat. Prod. Commun. 2013, 8(6), 1934578X1300800627. DOI: 10.1177/1934578x1300800627. DOI: https://doi.org/10.1177/1934578X1300800627

Tan, F.; Chen, Y.; Tan, X.; Ma, Y.; Peng, Y. Chinese materia medica used in medicinal diets. J. Ethnopharmacol. 2017, 206, 40-54. DOI: 10.1016/j.jep.2017.05.021. DOI: https://doi.org/10.1016/j.jep.2017.05.021

Dafni, A.; Yaniv, Z. Solanaceae as medicinal plants in Israel. J. Ethnopharmacol. 1994, 44(1), 11-18. DOI: 10.1016/0378-8741(94)90093-0. DOI: https://doi.org/10.1016/0378-8741(94)90093-0

Magiera, S.; Zaręba, M. Chromatographic determination of phenolic acids and flavonoids in Lycium barbarum L. and evaluation of antioxidant activity. Food Anal. Methods 2015, 8(10), 2665-2674. DOI: 10.1007/s12161-015-0166-y. DOI: https://doi.org/10.1007/s12161-015-0166-y

Lin, C. L.; Wang, C. C.; Chang, S. C.; Inbaraj, B. S.; Chen, B. H. Antioxidative activity of polysaccharide fractions isolated from Lycium barbarum Linnaeus. Int. J. Biol. Macromol. 2009, 45(2), 146-151. DOI: 10.1016/j.ijbiomac.2009.04.014. DOI: https://doi.org/10.1016/j.ijbiomac.2009.04.014

Benchennouf, A.; Grigorakis, S.; Loupassaki, S.; Kokkalou, E. Phytochemical analysis and antioxidant activity of Lycium barbarum (Goji) cultivated in Greece. Pharm. Biol. 2017, 55(1), 596-602. DOI: 10.1080/13880209.2016.1265987. DOI: https://doi.org/10.1080/13880209.2016.1265987

Li, X. M.; Li, X. L.; Zhou, A. G. Evaluation of antioxidant activity of the polysaccharides extracted from Lycium barbarum fruits in vitro. Eur. Polym. J. 2007, 43(2), 488-497. DOI: 10.1016/j.eurpolymj.2006.10.025. DOI: https://doi.org/10.1016/j.eurpolymj.2006.10.025

Le, K.; Chiu, F.; Ng, K. Identification and quantification of antioxidants in Fructus lycii. Food Chem. 2007, 105(1), 353-363. DOI: 10.1016/j.foodchem.2006.11.063. DOI: https://doi.org/10.1016/j.foodchem.2006.11.063

Vicente, O.; Boscaiu, M. Flavonoids: antioxidant compounds for plant defence... and for a healthy human diet. Not. Bot. Horti Agrobo. 2018, 46(1), 14-21. DOI: 10.15835/nbha46110992. DOI: https://doi.org/10.15835/nbha46110992

Zhishen, J.; Mengcheng, T.; Jianming, W. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 1999, 64(4), 555-559. DOI: 10.1016/S0308-8146(98)00102-2. DOI: https://doi.org/10.1016/S0308-8146(98)00102-2

Trevithick-Sutton, C. C.; Foote, C. S.; Collins, M.; Trevithick, J. R. The retinal carotenoids zeaxanthin and lutein scavenge superoxide and hydroxyl radicals: a chemiluminescence and ESR study. Mol. Vis. 2006, 12(12), 1127-1135.

Liang, B.; Peng, L.; Li, R.; Li, H.; Mo, Z.; Dai, X.; Jiang, N.; Liu, Q.; Zhang, E.; Deng, H.; Li, Z.; Zhu, H. Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2. Cell. Mol. Biol. Lett. 2018, 23, 18. DOI: 10.1186/s11658-018-0084-2. DOI: https://doi.org/10.1186/s11658-018-0084-2

Li, H.; Li, Z.; Peng, L.; Jiang, N.; Liu, Q.; Zhang, E.; Liang, B.; Li, R.; Zhu, H. Lycium barbarum polysaccharide protects human keratinocytes against UVB-induced photo-damage. Free Radic. Res. 2017, 51(2), 200-210. DOI: 10.1080/10715762.2017.1294755. DOI: https://doi.org/10.1080/10715762.2017.1294755

Yang, Y.; Li, W.; Li, Y.; Wang, Q.; Gao, L.; Zhao, J. Dietary Lycium barbarum polysaccharide induces Nrf2/ARE pathway and ameliorates Insulin resistance induced by high-fat via activation of PI3K/AKT signaling. Oxid. Med. Cell. Longev. 2014, 2014, 145641. DOI: 10.1155/2014/145641. DOI: https://doi.org/10.1155/2014/145641

Niu, A.-j.; Wu, J.-m.; Yu, D.-h.; Wang, R. Protective effect of Lycium barbarum polysaccharides on oxidative damage in skeletal muscle of exhaustive exercise rats. Int. J. Biol. Macromol. 2008, 42(5), 447-449. DOI: 10.1016/j.ijbiomac.2008.02.003. DOI: https://doi.org/10.1016/j.ijbiomac.2008.02.003

Zhao, R.; Hao, W.; Ma, B.; Chen, Z. Improvement effect of Lycium barbarum polysaccharide on sub-health mice. Iran. J. Basic Med. Sci. 2015, 18(12), 1245-1252.

Wang, S.-F.; Liu, X.; Ding, M.-Y.; Ma, S.; Zhao, J.; Wang, Y.; Li, S. 2-O-β-d-glucopyranosyl-l-ascorbic acid, a novel vitamin C derivative from Lycium barbarum, prevents oxidative stress. Redox Biol. 2019, 24, 101173. DOI: 10.1016/j.redox.2019.101173. DOI: https://doi.org/10.1016/j.redox.2019.101173

Amagase, H.; Sun, B.; Borek, C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr. Res. 2009, 29(1), 19-25. DOI: 10.1016/j.nutres.2008.11.005. DOI: https://doi.org/10.1016/j.nutres.2008.11.005

Wu, W.-B.; Hung, D.-K.; Chang, F.-W.; Ong, E.-T.;Chen, B.-H. Anti-inflammatory and anti-angiogenic effects of flavonoids isolated from Lycium barbarum Linnaeus on human umbilical vein endothelial cells. Food Funct. 2012, 3(10), 1068-1081. DOI: 10.1039/C2FO30051F. DOI: https://doi.org/10.1039/c2fo30051f

Liu, Y.; Lv, J.; Yang, B.; Liu, F.; Tian, Z.; Cai, Y.; Yang, D.; Ouyang, J.; Sun, F.; Shi, Y.; Xia, P. Lycium barbarum polysaccharide attenuates type II collagen-induced arthritis in mice. Int. J. Biol. Macromol. 2015, 78, 318-323. DOI: 10.1016/j.ijbiomac.2015.04.025. DOI: https://doi.org/10.1016/j.ijbiomac.2015.04.025

Cheng, J.; Zhou, Z. W.; Sheng, H. P.; He, L. J.; Fan, X. W.; He, Z. X.; Sun, T.; Zhang, X.; Zhao, R. J.; Gu, L.; Cao, C.; Zhou, S. F. An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides. Drug Des. Devel. Ther. 2015, 9, 33-78. DOI: 10.2147/dddt.S72892. DOI: https://doi.org/10.2147/DDDT.S72892

Zhang, X. R.; Zhou, W. X.; Zhang, Y. X.; Qi, C. H.; Yan, H.; Wang, Z. F.; Wang, B. Macrophages, rather than T and B cells are principal immunostimulatory target cells of Lycium barbarum L. polysaccharide LBPF4-OL. J. Ethnopharmacol. 2011, 136(3), 465-472. DOI: 10.1016/j.jep.2011.04.054. DOI: https://doi.org/10.1016/j.jep.2011.04.054

Deng, X.; Liu, Q.; Fu, Y.; Luo, X.; Hu, M.; Ma, F.; Wang, Q.; Lai, X.; Zhou, L. Effects of Lycium barbarum polysaccharides with different molecular weights on function of RAW264.7 macrophages. Food Agric. Immunol. 2018, 29(1), 808-820. DOI: 10.1080/09540105.2018.1457628. DOI: https://doi.org/10.1080/09540105.2018.1457628

Zhu, J.; Zhao, L.-H.; Zhao, X.-P.; Chen, Z. Lycium barbarum polysaccharides regulate phenotypic and functional maturation of murine dendritic cells. Cell Biol. Int. 2007, 31(6), 615-619. DOI: 10.1016/j.cellbi.2006.12.002. DOI: https://doi.org/10.1016/j.cellbi.2006.12.002

Amagase, H. S., Bixuang, S.; Nance, D. M. Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects. J. Med. Food 2009, 12(5), 1159-1165. DOI: 10.1089/jmf.2008.0300. DOI: https://doi.org/10.1089/jmf.2008.0300

Vidal, K.; Bucheli, P.; Gao, Q.; Moulin, J.; Shen, L.-S.; Wang, J.; Blum, S.; Benyacoub, J. Immunomodulatory effects of dietary supplementation with a milk-based wolfberry formulation in healthy elderly: a randomized, double-blind, placebo-controlled trial. Rejuvenation Res. 2012, 15(1), 89-97. DOI: 10.1089/rej.2011.1241. DOI: https://doi.org/10.1089/rej.2011.1241

Alassadi, I. J.; Sabah, F. S.; Alrubaie, L. A. Isolation of flavonoid compound from iraqi awsaj plant (Lycium barbarum L.) fruits and the study of its antibacterial activity. Eur. Sci. J. 2015, 11(24).

Wang, J.; Hu, Y.; Wang, D.; Zhang, F.; Zhao, X.; Abula, S.; Fan, Y.; Guo, L. Lycium barbarum polysaccharide inhibits the infectivity of Newcastle disease virus to chicken embryo fibroblast. Int. J. Biol. Macromol. 2010, 46(2), 212-216. DOI: 10.1016/j.ijbiomac.2009.11.011. DOI: https://doi.org/10.1016/j.ijbiomac.2009.11.011

Cai, H.; Yang, X.; Cai, Q.; Ren, B.; Qiu, H.; Yao, Z. Lycium barbarum L. polysaccharide (LBP) reduces glucose uptake via down-regulation of SGLT-1 in Caco2 cell. Molecules 2017, 22(2), 341. DOI: 10.3390/molecules22020341. DOI: https://doi.org/10.3390/molecules22020341

Tang, H.-L.; Chen, C.; Wang, S.-K.; Sun, G.-J. Biochemical analysis and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L. Int. J. Biol. Macromol. 2015, 77, 235-242. DOI: 10.1016/j.ijbiomac.2015.03.026. DOI: https://doi.org/10.1016/j.ijbiomac.2015.03.026

Zhao, R.; Qiu, B.; Li, Q.; Zhang, T.; Zhao, H.; Chen, Z.; Cai, Y.; Ruan, H.; Ge, W.;Zheng, X. LBP-4a improves insulin resistance via translocation and activation of GLUT4 in OLETF rats. Food Funct. 2014, 5(4), 811-820. DOI: 10.1039/C3FO60602C. DOI: https://doi.org/10.1039/C3FO60602C

Zhao, R.; Gao, X.; Zhang, T.; Li, X. Effects of Lycium barbarum polysaccharide on type 2 diabetes mellitus rats by regulating biological rhythms. Iran. J. Basic Med. Sci. 2016, 19(9), 1024-1030.

Zou, S.; Zhang, X.; Yao, W.; Niu, Y.; Gao, X. Structure characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Lycium barbarum L. Carbohydr. Polym. 2010, 80(4), 1161-1167. DOI: 10.1016/j.carbpol.2010.01.038. DOI: https://doi.org/10.1016/j.carbpol.2010.01.038

Zhu, J.; Liu, W.; Yu, J.; Zou, S.; Wang, J.; Yao, W.; Gao, X. Characterization and hypoglycemic effect of a polysaccharide extracted from the fruit of Lycium barbarum L. Carbohydr. Polym. 2013, 98(1), 8-16. DOI: 10.1016/j.carbpol.2013.04.057. DOI: https://doi.org/10.1016/j.carbpol.2013.04.057

Kou, L.; Du, M.; Zhang, C.; Dai, Z.; Li, X.; Zhang, B. The hypoglycemic, hypolipidemic, and anti-diabetic nephritic activities of zeaxanthin in diet-streptozotocin-induced diabetic Sprague Dawley rats. Appl. Biochem. Biotechnol. 2017, 182(3), 944-955. DOI: 10.1007/s12010-016-2372-5. DOI: https://doi.org/10.1007/s12010-016-2372-5

Cui, G.; Jing, L.; Feng, Q.; Xiao, Y.; Putheti, R. Anti-hyperglycemic activity of a polysaccharide fraction from Lycium barbarum. Afr. J. Biomed. Res. 2010, 13(1), 55-59.

Jing, L.; Yin, L. Antihyperglycemic activity of polysaccharide from Lycium barbarum. J. Med. Plant Res. 2010, 4(1), 23-26.

Cai, H.; Liu, F.; Zuo, P.; Huang, G.; Song, Z.; Wang, T.; Lu, H.; Guo, F.; Han, C.; Sun, G. Practical application of antidiabetic efficacy of Lycium barbarum polysaccharide in patients with type 2 diabetes. Med. Chem. 2015, 11(4), 383-390. DOI: 10.2174/1573406410666141110153858. DOI: https://doi.org/10.2174/1573406410666141110153858

Cheng, D.; Kong, H. The effect of Lycium barbarum polysaccharide on alcohol-induced oxidative stress in rats. Molecules 2011, 16(3), 2542-2550. DOI: 10.3390/molecules16032542. DOI: https://doi.org/10.3390/molecules16032542

Wang, F.; Tipoe, G. L.; Yang, C.; Nanji, A. A.; Hao, X.; So, K.-F.; Xiao, J. Lycium barbarum polysaccharide supplementation improves alcoholic liver injury in female mice by inhibiting stearoyl-CoA desaturase 1. Mol. Nutr. Food Res. 2018, 62(13), 1800144. DOI: 10.1002/mnfr.201800144. DOI: https://doi.org/10.1002/mnfr.201800144

Xiao, J.; Xing, F.; Huo, J.; Fung, M. L.; Liong, E. C.; Ching, Y. P.; Xu, A.; Chang, R. C. C.; So, K. F.; Tipoe, G. L. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Sci. Rep. 2014, 4(1), 5587. DOI: 10.1038/srep05587. DOI: https://doi.org/10.1038/srep05587

Xiao, J.; Wang, F.; Liong, E. C.; So, K.-F.; Tipoe, G. L. Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model. Int. J. Biol. Macromol. 2018, 120, 1480-1489. DOI: 10.1016/j.ijbiomac.2018.09.151. DOI: https://doi.org/10.1016/j.ijbiomac.2018.09.151

Xiao, J.; Liong, E. C.; Ching, Y. P.; Chang, R. C. C.; Fung, M. L.; Xu, A. M.; So, K. F.; Tipoe, G. L. Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury. Nutr. Diabetes 2013, 3(7), e81-e81. DOI: 10.1038/nutd.2013.22. DOI: https://doi.org/10.1038/nutd.2013.22

Li, W.; Li, Y.; Wang, Q.; Yang, Y. Crude extracts from Lycium barbarum suppress SREBP-1c expression and prevent diet-induced fatty liver through AMPK activation. Biomed Res. Int. 2014, 2014, 196198. DOI: 10.1155/2014/196198. DOI: https://doi.org/10.1155/2014/196198

Gündüz, E.; Dursun, R.; Zengin, Y.; İçer, M.; Durgun, H. M.; Kanıcı, A.; Kaplan, İ.; Alabalık, U.; Gürbüz, H.; Güloğlu, C. Lycium barbarum extract provides effective protection against paracetamol-induced acute hepatotoxicity in rats. Int. J. Clin. Exp. Med. 2015, 8(5), 7898-7905.

Gan, F.; Liu, Q.; Liu, Y.; Huang, D.; Pan, C.; Song, S.; Huang, K. Lycium barbarum polysaccharides improve CCl4-induced liver fibrosis, inflammatory response and TLRs/NF-kB signaling pathway expression in Wistar rats. Life Sci. 2018, 192, 205-212. DOI: 10.1016/j.lfs.2017.11.047. DOI: https://doi.org/10.1016/j.lfs.2017.11.047

Allen, C. L.; Bayraktutan, U. Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int. J. Stroke 2009, 4(6), 461-470. DOI: 10.1111/j.1747-4949.2009.00387.x. DOI: https://doi.org/10.1111/j.1747-4949.2009.00387.x

Hu, X.; Qu, Y.; Chu, Q.; Li, W.; He, J. Investigation of the neuroprotective effects of Lycium barbarum water extract in apoptotic cells and Alzheimer's disease mice. Mol. Med. Rep. 2018, 17(3), 3599-3606. DOI: 10.3892/mmr.2017.8310. DOI: https://doi.org/10.3892/mmr.2017.8310

Zhou, L.; Liao, W.; Chen, X.; Yue, H.; Li, S.; Ding, K. An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of Aβ42. Carbohydr. Polym. 2018, 195, 643-651. DOI: 10.1016/j.carbpol.2018.05.022. DOI: https://doi.org/10.1016/j.carbpol.2018.05.022

Zhou, L.; Liao, W.; Zeng, H.; Yao, Y.; Chen, X.; Ding, K. A pectin from fruits of Lycium barbarum L. decreases β-amyloid peptide production through modulating APP processing. Carbohydr. Polym. 2018, 201, 65-74. DOI: 10.1016/j.carbpol.2018.08.050. DOI: https://doi.org/10.1016/j.carbpol.2018.08.050

Zhao, P.; Zhou, R.; Zhu, X.-Y.; Liu, G.; Zhao, Y.-P.; Ma, P.-S.; Wu, W.; Niu, Y.; Sun, T.; Li, Y.-X.; Yu, J.-Q.; Qian, Z.-M. Neuroprotective effects of Lycium barbarum polysaccharide on focal cerebral ischemic injury in mice. Neurochem. Res. 2017, 42(10), 2798-2813. DOI: 10.1007/s11064-017-2293-x. DOI: https://doi.org/10.1007/s11064-017-2293-x

Shi, Z.; Zhu, L.; Li, T.; Tang, X.; Xiang, Y.; Han, X.; Xia, L.; Zeng, L.; Nie, J.; Huang, Y.; Tsang, C. K.; Wang, Y.; Lei, Z.; Xu, Z.; So, K.-f.; Ruan, Y. Neuroprotective mechanisms of Lycium barbarum polysaccharides against Ischemic insults by regulating NR2B and NR2A containing NMDA receptor signaling pathways. Front. Cell. Neurosci. 2017, 11. DOI: 10.3389/fncel.2017.00288. DOI: https://doi.org/10.3389/fncel.2017.00288

Wang, X.; Pang, L.; Zhang, Y.; Xu, J.; Ding, D.; Yang, T.; Zhao, Q.; Wu, F.; Li, F.; Meng, H.; Yu, D. Lycium barbarum polysaccharide promotes nigrostriatal dopamine function by modulating PTEN/AKT/mTOR pathway in a methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson’s disease. Neurochem. Res. 2018, 43(4), 938-947. DOI: 10.1007/s11064-018-2499-6. DOI: https://doi.org/10.1007/s11064-018-2499-6

Xie, Y.; Wang, X. Lycium barbarum polysaccharides attenuates the apoptosis of hippocampal neurons induced by sevoflurane. Exp. Ther. Med. 2018, 16(3), 1834-1840. DOI: 10.3892/etm.2018.6426. DOI: https://doi.org/10.3892/etm.2018.6426

Yu, Y.; Wu, X.; Pu, J.; Luo, P.; Ma, W.; Wang, J.; Wei, J.; Wang, Y.; Fei, Z. Lycium barbarum polysaccharide protects against oxygen glucose deprivation/reoxygenation-induced apoptosis and autophagic cell death via the PI3K/Akt/mTOR signaling pathway in primary cultured hippocampal neurons. Biochem. Biophys. Res. Commun. 2018, 495(1), 1187-1194. DOI: 10.1016/j.bbrc.2017.11.165. DOI: https://doi.org/10.1016/j.bbrc.2017.11.165

Lam, C.-S.; Tipoe, G. L.; So, K.-F.; Fung, M.-L. Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PLOS ONE 2015, 10(2), e0117990. DOI: 10.1371/journal.pone.0117990. DOI: https://doi.org/10.1371/journal.pone.0117990

Chien, K. J.; Horng, C. T.; Huang, Y. S.; Hsieh, Y. H.; Wang, C. J.; Yang, J. S.; Lu, C. C.; Chen, F. A. Effects of Lycium barbarum (goji berry) on dry eye disease in rats. Mol. Med. Rep. 2018, 17(1), 809-818. DOI: 10.3892/mmr.2017.7947. DOI: https://doi.org/10.3892/mmr.2017.7947

Pavan, B.; Capuzzo, A.; Forlani, G. High glucose-induced barrier impairment of human retinal pigment epithelium is ameliorated by treatment with Goji berry extracts through modulation of cAMP levels. Exp. Eye Res. 2014, 120, 50-54. DOI: 10.1016/j.exer.2013.12.006. DOI: https://doi.org/10.1016/j.exer.2013.12.006

Wang, Y.; Ding, L.; Li, Y.; Guan, C.; Guo, J. Lycium barbarum polysaccharides can reduce the oxidative damage of the retinal nerve cells in diabetic rats. Int. J. Clin. Exp. Med. 2017, 10(3), 5168-5174.

Tang, L.; Bao, S.; Du, Y.; Jiang, Z.; Wuliji, A. O.; Ren, X.; Zhang, C.; Chu, H.; Kong, L.; Ma, H. Antioxidant effects of Lycium barbarum polysaccharides on photoreceptor degeneration in the light-exposed mouse retina. Biomed. Pharmacother. 2018, 103, 829-837. DOI: 10.1016/j.biopha.2018.04.104. DOI: https://doi.org/10.1016/j.biopha.2018.04.104

Liu, F.; Zhang, J.; Xiang, Z.; Xu, D.; So, K.-F.; Vardi, N.; Xu, Y. Lycium barbarum polysaccharides protect retina in rd1 mice during photoreceptor degeneration. Invest. Ophthalmol. Vis. Sci. 2018, 59(1), 597-611. DOI: 10.1167/iovs.17-22881. DOI: https://doi.org/10.1167/iovs.17-22881

Li, H.-Y.; Ruan, Y.-W.; Kau, P. W.-F.; Chiu, K.; Chang, R. C.-C.; Chan, H. H. L.; So, K.-F. Effect of Lycium barbarum (wolfberry) on alleviating axonal degeneration after partial optic nerve transection. Cell. Transplant. 2015, 24(3), 403-417. DOI: 10.3727/096368915X686896. DOI: https://doi.org/10.3727/096368915X686896

Bie, M.; Lv, Y.; Ren, C.; Xing, F.; Cui, Q.; Xiao, J.; So, K. F. Lycium barbarum polysaccharide improves bipolar pulse current-induced microglia cell injury through modulating autophagy. Cell Transplant. 2015, 24(3), 419-428. DOI: 10.3727/096368915x687453. DOI: https://doi.org/10.3727/096368915X687453

Xia, G.; Xin, N.; Liu, W.; Yao, H.; Hou, Y.; Qi, J. Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway. Mol. Med. Rep. 2014, 9(4), 1237-1241. DOI: 10.3892/mmr.2014.1964. DOI: https://doi.org/10.3892/mmr.2014.1964

Liu, L.; Wang, X. N.; Liu, Z.; Wang, L. N.; Wu, J.; Wang, W.; Feng, J. X. Abstrakt: Effect of Lycium barbarum polysaccharides on angiotensin II-induced senescence of human umbilical vein endothelial cells and expressions of P53 and P16. Nan Fang Yi Ke Da Xue Xue Bao 2011, 31(7), 1212-1215.

Tang, T.; He, B. Treatment of D-galactose induced mouse aging with Lycium barbarum polysaccharides and its mechanism study. Afr. J. Tradit. Complement. Altern. Med. 2013, 10(4), 12-17. DOI: 10.4314/ajtcam.v10i4.3. DOI: https://doi.org/10.4314/ajtcam.v10i4.3

Yi, R.; Liu, X. M.; Dong, Q. A study of Lycium barbarum polysaccharides (LBP) extraction technology and its anti-aging effect. Afr. J. Tradit. Complement. Altern. Med. 2013, 10(4), 171-174. DOI: 10.4314/ajtcam.v10i4.27. DOI: https://doi.org/10.4314/ajtcam.v10i4.27

Yao, L.-Q.; Li, F.-L. Lycium barbarum polysaccharides ameliorates physical fatigue. Afr. J. Agric. Res. 2010, 5(16), 2153-2157. DOI: 10.5897/AJAR10.485.

Amagase, H.; Nance, D. M. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (goji) juice, GoChi™. J. Altern. Complement. Med. 2008, 14(4), 403-412. DOI: 10.1089/acm.2008.0004. DOI: https://doi.org/10.1089/acm.2008.0004

Hsu, C.-H.; Nance, D. M.; Amagase, H. A meta-analysis of clinical improvements of general well-being by a standardized Lycium barbarum. J. Med. Food 2012, 15(11), 1006-1014. DOI: 10.1089/jmf.2012.0013. DOI: https://doi.org/10.1089/jmf.2012.0013

Guo, X. F.; Li, Z. H.; Cai, H.; Li, D. The effects of Lycium barbarum L. (L. barbarum) on cardiometabolic risk factors: a meta-analysis of randomized controlled trials. Food Funct. 2017, 8(5), 1741-1748. DOI: 10.1039/c7fo00183e. DOI: https://doi.org/10.1039/C7FO00183E

Zeng, X.; Zhao, W.; Wang, S.; Xiong, H.; Wu, J.; Ren, J. L. barbarum (Lycium barbarum L.) supplementation for lipid profiles in adults: a systematic review and meta-analysis of RCTs. Medicine (Baltimore) 2023, 102(39), e34952. DOI: 10.1097/md.0000000000034952. DOI: https://doi.org/10.1097/MD.0000000000034952

Toh, D. W. K.; Low, J. H. M.; Kim, J. E. Cardiovascular disease risk reduction with wolfberry consumption: a systematic review and meta-analysis of randomized controlled trials. Eur. J. Nutr. 2022, 61(3), 1177-1186. DOI: 10.1007/s00394-021-02750-6. DOI: https://doi.org/10.1007/s00394-021-02750-6

Toh, D. W. K.; Xia, X.; Sutanto, C. N.; Low, J. H. M.; Poh, K. K.; Wang, J. W.; Foo, R. S.; Kim, J. E. Enhancing the cardiovascular protective effects of a healthy dietary pattern with wolfberry (Lycium barbarum): a randomized controlled trial. Am. J. Clin. Nutr. 2021, 114(1), 80-89. DOI: 10.1093/ajcn/nqab062. DOI: https://doi.org/10.1093/ajcn/nqab062

Amagase, H.; Nance, D. M. Lycium barbarum increases caloric expenditure and decreases waist circumference in healthy overweight men and women: pilot study. J. Am. Coll. Nutr. 2011, 30(5), 304-309. DOI: 10.1080/07315724.2011.10719973. DOI: https://doi.org/10.1080/07315724.2011.10719973

Chan, H. H.; Lam, H. I.; Choi, K. Y.; Li, S. Z.; Lakshmanan, Y.; Yu, W. Y.; Chang, R. C.; Lai, J. S.; So, K. F. Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement. J Ethnopharmacol. 2019, 236, 336-344. DOI: 10.1016/j.jep.2019.03.023. DOI: https://doi.org/10.1016/j.jep.2019.03.023

Li, X.; Holt, R. R.; Keen, C. L.; Morse, L. S.; Yiu, G.; Hackman, R. M. Goji berry intake increases macular pigment optical density in healthy adults: a randomized pilot trial. Nutrients 2021, 13(12). DOI: 10.3390/nu13124409. DOI: https://doi.org/10.3390/nu13124409

Zhang, Y.; Hao, J.; Cao, K.; Qi, Y.; Wang, N.; Han, S. Macular pigment optical density responses to different levels of zeaxanthin in patients with high myopia. Graefes Arch. Clin. Exp. Ophthalmol. 2022, 260(7), 2329-2337. DOI: 10.1007/s00417-021-05532-2. DOI: https://doi.org/10.1007/s00417-021-05532-2

Cheng, C. Y.; Chung, W. Y.; Szeto, Y. T.; Benzie, I. F. Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; Kei Tze) in a food-based human supplementation trial. Br. J. Nutr. 2005, 93(1), 123-130. DOI: 10.1079/bjn20041284. DOI: https://doi.org/10.1079/BJN20041284

Bucheli, P.; Vidal, K.; Shen, L.; Gu, Z.; Zhang, C.; Miller, L. E.; Wang, J. Goji berry effects on macular characteristics and plasma antioxidant levels. Optom. Vis. Sci. 2011, 88(2), 257-262. DOI: 10.1097/OPX.0b013e318205a18f. DOI: https://doi.org/10.1097/OPX.0b013e318205a18f

Benzie, I. F.; Chung, W. Y.; Wang, J.; Richelle, M.; Bucheli, P. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.). Br J Nutr 2006, 96(1), 154-160. DOI: 10.1079/bjn20061796. DOI: https://doi.org/10.1079/BJN20061796

Ni, Y.; Mu, C.; He, X.; Zheng, K.; Guo, H.; Zhu, W. Characteristics of gut microbiota and its response to a Chinese Herbal Formula in elder patients with metabolic syndrome. Drug Discov. Ther. 2018, 12(3), 161-169. DOI: 10.5582/ddt.2018.01036. DOI: https://doi.org/10.5582/ddt.2018.01036

Lu, J.; Gao, Y.; Gong, Y.; Yue, Y.; Yang, Y.; Xiong, Y.; Zhang, Y.; Xiao, Y.; Wang, H.; Fan, H.; Shi, X. Lycium barbarum L. balanced intestinal flora with YAP1/FXR activation in drug-induced liver injury. Int. Immunopharmacol. 2024, 130, 111762. DOI: 10.1016/j.intimp.2024.111762. DOI: https://doi.org/10.1016/j.intimp.2024.111762

142. Zhuang, J.; Chen, Q.; Xu, L.; Qiao, D.; Chen, X. Lycium barbarum polysaccharide mitigated methamphetamine addiction and altered methamphetamine-induced gut microbiota dysbiosis. Electrophoresis 2024. DOI: 10.1002/elps.202300190. DOI: https://doi.org/10.1002/elps.202300190

Liu, Y.; Liu, L.; Luo, J.; Peng, X. Metabolites from specific intestinal bacteria in vivo fermenting Lycium barbarum polysaccharide improve collagenous arthritis in rats. Int. J. Biol. Macromol. 2023, 226, 1455-1467. DOI: 10.1016/j.ijbiomac.2022.11.257. DOI: https://doi.org/10.1016/j.ijbiomac.2022.11.257

Yan, A.; Ding, H.; Liu, J.; Bi, C.; Han, Z.; Wang, Z.; Nawaz, S.; Shen, Y.; Liu, S. Black Lycium barbarum polysaccharide attenuates LPS-induced intestine damage via regulation gut microbiota. Front. Microbiol. 2022, 13, 1080922. DOI: 10.3389/fmicb.2022.1080922. DOI: https://doi.org/10.3389/fmicb.2022.1080922

Li, Z. Y.; Lin, L. H.; Liang, H. J.; Li, Y. Q.; Zhao, F. Q.; Sun, T. Y.; Liu, Z. Y.; Zhu, J. Y.; Gu, F.; Xu, J. N.; Hao, Q. Y.; Zhou, D. S.; Zhai, H. H. Lycium barbarum polysaccharide alleviates DSS-induced chronic ulcerative colitis by restoring intestinal barrier function and modulating gut microbiota. Ann. Med. 2023, 55(2), 2290213. DOI: 10.1080/07853890.2023.2290213. DOI: https://doi.org/10.1080/07853890.2023.2290213

Zhou, W.; Kan, X.; Chen, G.; Sun, Y.; Ran, L.; Yan, Y.; Mi, J.; Lu, L.; Zeng, X.; Cao, Y. The polysaccharides from the fruits of Lycium barbarum L. modify the gut community profile and alleviate dextran sulfate sodium-induced colitis in mice. Int. J. Biol. Macromol. 2022, 222, 2244-2257. DOI: 10.1016/j.ijbiomac.2022.10.015. DOI: https://doi.org/10.1016/j.ijbiomac.2022.10.015

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2024-08-08

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Lycium barbarum fruits –phytochemistry and activity of goji berries – from tradition to clinical studies. (2024). Prospects in Pharmaceutical Sciences, 22(3), 35-57. https://doi.org/10.56782/pps.197