FUNGAL BIOTECHNOLOGY. APPLICATIONS IN PHARMACY AND SUPPLEMENTATION
DOI:
https://doi.org/10.56782/pps.94Keywords:
Lentinula edodes, mycelial cultures, selenium, immunomodulation, dietary supplementsAbstract
Many Basidiomycetes mushrooms have the ability to synthesize bioactive compounds, including anticancer agents that can be isolated from fruit bodies, mycelial cultures, or culture media. Lentinula edodes (Berk.) Pegl. is one of the most widely used medicinal mushrooms. This mushroom is the source of two drugs approved in several countries. Both drugs are immunomodulators and are used in cancer therapy. In addition, L. edodes forms compounds with antibacterial, antiviral, cholesterol lowering, and anticoagulant activities. Water-soluble lignans derived from L. edodes culture medium are being tested as potential drugs for the treatment of hepatitis B and AIDS. L. edodes protein is made up of 18 amino acids, including all essential amino acids, in ratios appropriate for humans. The fruit bodies of the mushroom contain considerable amounts of vitamins C, B1, B2, PP, B12 and D. Immunomodulatory polysaccharides isolated from L. edodes are being used in chemoprevention and as adjuvants in cancer treatment because of their ability to alleviate undesirable side effects of such therapies. This valuable mushroom is also used to produce dietary supplements.
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