Kawka M., Ekstrakcja in situ naftochinonów w hodowli korzeni transformowanych Rindera graeca (In situ extraction of naphthoquinones in Rindera graeca transformed hairy root cultures). Praca dyplomowa na stopień magistra inżyniera wykonana w Zakładzie Biotechnologii i Inżynierii Bioprocesowej Wydziału Inżynierii Chemicznej i Procesowej Politechniki Warszawskiej i w Zakładzie Biologii Farmaceutycznej i Biotechnologii Roślin Leczniczych Wydziału Farmaceutycznego z Oddziałem Medycyny Laboratoryjnej Warszawskiego Uniwersytetu Medycznego 2016.

Grajek W., Biosynteza metabolitów wtórnych w kulturach in vitro. W: Malepszy S. (red.), Biotechnologia roślin (s. 306-340), Wydawnictwo Naukowe PWN 2007.

Ramachandra Rao S. & Ravishankar G. A., Plant cell cultures: Chemical factories of secondary metabolites. Biotechnology Advances 2002, 20, 101–153. DOI: https://doi.org/10.1016/S0734-9750(02)00007-1

Georgiev M. I., Pavlov A. I. & Bley T., Hairy root type plant in vitro systems as sources of bioactive substances. Applied Microbiology and Biotechnology 2007, 74, 1175–1185. DOI: https://doi.org/10.1007/s00253-007-0856-5

Murthy H. N., Lee E.-J. & Paek K.-Y., Production of secondary metabolites from cell and organ cultures: Strategies and approaches for biomass improvement and metabolite accumulation. Plant Cell, Tissue and Organ Culture 2014, 118, 1–16. DOI: https://doi.org/10.1007/s11240-014-0467-7

Dörnenburg H. & Knorr D., Strategies for the improvement of secondary metabolite production in plant cell cultures. Enzyme and Microbial Technology 1995, 17, 674–684. DOI: https://doi.org/10.1016/0141-0229(94)00108-4

Bourgaud F., Gravot A., Milesi S. & Gontier E., Production of plant secondary metabolites: A historical perspective. Plant Science 2001, 161, 839–851. DOI: https://doi.org/10.1016/S0168-9452(01)00490-3

Skucińska B., Kultura komórek i tkanek. W: Malepszy S. (red.), Biotechnologia roślin (s. 19-31), Wydawnictwo Naukowe PWN 2007.

Ruffoni B., Pistelli L., Bertoli A. & Pistelli L., Plant cell cultures: Bioreactors for industrial production. W: Giardi M. T., Rea G., Berra B., Bio-Farms for nutraceuticals (s. 203-221), Advances in experimental medicine and biology 2010. DOI: https://doi.org/10.1007/978-1-4419-7347-4_15

Su W. W., Bioprocessing technology for plant cell suspension cultures. Applied Biochemistry and Biotechnology 1995, 50, 189–230. DOI: https://doi.org/10.1007/BF02783455

Hippolyte I., Marin B., Baccou J. C. & Jonard R., Growth and rosmarinic acid production in cell suspension cultures of Salvia officinalis L. Plant Cell Reports 1992, 11, 109–112. DOI: https://doi.org/10.1007/BF00232160

Fujita Y., Industrial Production of shikonin and berberine. W: Gregory Bock, Joan Marsh (red.), Ciba Foundation Symposium 137 - Applications of Plant Cell and Tissue Culture (s. 228-238), John Wiley & Sons Ltd. 2007. DOI: https://doi.org/10.1002/9780470513651.ch16

Zenk M. H., El-Shagi H. & Schulte U., Anthraquinone production by cell suspension cultures of Morinda citrifolia. Planta Medica 1975, Suppl, 79–101. DOI: https://doi.org/10.1055/s-0028-1104768

Kobayashi Y., Fukui H. & Tabata M., Berberine production by batch and semi-continuous cultures of immobilized Thalictrum cells in an improved bioreactor. Plant Cell Reports 1988, 7, 249–252. DOI: https://doi.org/10.1007/BF00272535

Breuling M., Alfermann A. W. & Reinhard E., Cultivation of cell cultures of Berberis wilsonae in 20-l airlift bioreactors. Plant Cell Reports 1985, 4, 220–223. DOI: https://doi.org/10.1007/BF00269294

Zhong J.-J., Konstantinov K. B. & Yoshida T., Computer-aided on-line monitoring of physiological variables in suspended cell cultures of Perilla frutescens in a bioreactor. Journal of Fermentation and Bioengineering 1994, 77, 445–447. DOI: https://doi.org/10.1016/0922-338X(94)90023-X

Sahai O. & Knuth M., Commercializing plant tissue culture processes: Economics, problems and prospects. Biotechnology ProgressTM 1985, 1, 1–9. DOI: https://doi.org/10.1002/btpr.5420010104

Park J. M., Yoon S. Y., Giles K. L., Songstad D.D., Eppstein D., Novakowski D., Friesen L. & Roewer I., Production of sanguinarine by suspension culture of Papaver somniferum in bioreactors. Journal of Fermentation and Bioengineering 1992, 74, 292–296. DOI: https://doi.org/10.1016/0922-338X(92)90062-Y

Zenk M. H., El-Shagi H., Arens H., Stöckigt J., Weiler E. W. & Deus B., Formation of the indole alkaloids serpentine and ajmalicine in cell suspension cultures of Catharanthus roseus. W: Barz W., Reinhard E. & Zenk M. H. (red.), Plant Tissue Culture and Its Bio-technological Application (s. 27–43), Springer Berlin Heidelberg 1977. DOI: https://doi.org/10.1007/978-3-642-66646-9_3

Ibraheem Y., Pinker I. & Böhme M., A comparative study between solid and liquid cultures relative to callus growth and somatic embryo formation in Phoenix dactylifera L. cv. Zaghlool. Emirates Journal of Food and Agriculture 2013, 25, 883–898. DOI: https://doi.org/10.9755/ejfa.v25i11.16661

Grajek W., Kultury roślinne w bioreaktorach. W: Malepszy S. (red.), Biotechnologia roślin (s. 87-132), Wydawnictwo naukowe PWN 2007.

Uozumi N., Large-scale production of hairy root. Advances in biochemical engineering/biotechnology 2004, 91, 75–103. DOI: https://doi.org/10.1007/b94206

Giri A. & Narasu M. L., Transgenic hairy roots: Recent trends and applications. Biotechnology Advances 2000, 18, 1–22. DOI: https://doi.org/10.1016/S0734-9750(99)00016-6

Sharma P., Padh H. & Shrivastava N., Hairy root cultures: A suitable biological system for studying secondary metabolic pathways in plants. Engineering in Life Sciences 2013, 13, 62–75. DOI: https://doi.org/10.1002/elsc.201200030

Maldonado-Mendoza I. E., Ayora-Talavera T. & Loyola-Vargas V. M., Establishment of hairy root cultures of Datura stramonium. Characterization and stability of tropane alkaloid production during long periods of subculturing. Plant Cell, Tissue and Organ Culture 1993, 33, 321–329. DOI: https://doi.org/10.1007/BF02319018

Yukimune Y., Hara Y. & Yamada Y., Tropane alkaloid production in root cultures of Duboisia myoporoides obtained by repeated selection. Bioscience, Biotechnology and Biochemistry 1994, 58, 1443–1446. DOI: https://doi.org/10.1271/bbb.58.1443

Yu K.-W., Murthy H. N., Hahn E.-J. & Paek K.-Y., Ginsenoside production by hairy root cultures of Panax ginseng: Influence of temperature and light quality. Biochemical Engineering Journal 2005, 23, 53–56. DOI: https://doi.org/10.1016/j.bej.2004.07.001

Szopa J. & Łukaszewicz M., Tworzenie konstrukcji genowych. W: Malepszy S. (red.), Biotechnologia roślin (s.209-229), Wydawnictwo Naukowe PWN, 2007.

Ahn J. C., Chong W. S., Kim Y. S. & Hwang B., Optimization of the sucrose and ion concentrations for saikosaponin production in hairy root culture of Bupleurum falcatum. Biotechnology and Bioprocess Engineering 2006, 11, 121–126. DOI: https://doi.org/10.1007/BF02931895

Sakamoto K., Iida K., Sawamura K., Hajiro K., Asada Y., Yoshikava T. & Furuya T., Effects of nutrients on anthocyanin production in cultured cells of Aralia cordata. Phytochemistry 1993, 33, 357–360. DOI: https://doi.org/10.1016/0031-9422(93)85517-U

Jacob A. & Malpathak N., Manipulation of MS and B5 components for enhancement of growth and solasodine production in hairy root cultures of Solanum khasianum Clarke. Plant Cell, Tissue and Organ Culture 2005, 80, 247–257. DOI: https://doi.org/10.1007/s11240-004-0740-2

Ravishankar G. A., Sarma K. S., Venkataraman L. V. & Kadyan A. K., Effect of nutritional stress on capsaicin production in immobilized cell cultures of Capsicum annuum. Current Science 1988, 57, 381–383.

Rajasekaran T., Rajendran L., Ravishankar G. A. & Venkataraman L. V., Influence of nutrient stress on pyrethrin production by cultured cells of pyrethrum (Chrysanthemum cinerariaefolium). Current Science 1991, 60, 705–707.

Knobloch K.-H. & Berlin J., Influence of phosphate on the formation of the indole alkaloids and phenolic compounds in cell suspension cultures of Catharanthus roseus I. Comparison of enzyme activities and product accumulation. Plant Cell, Tissue and Organ Culture 1983, 2, 333–340. DOI: https://doi.org/10.1007/BF00039880

Hagimori M., Matsumoto T. & Obi Y., Studies on the production of Digitalis cardenolides by plant tissue culture: II. Effect of light and plant growth substances on digitoxin formation by undifferentiated cells and shoot-forming cultures of Digitalis purpurea L. grown in liquid media. Plant Physiol. 1982, 69, 653–656. DOI: https://doi.org/10.1104/pp.69.3.653

Kim Y.-S., Hahn E.-J., Yeung E. C. & Paek K.-Y., Lateral root development and saponin accumulation as affected by IBA or NAA in adventitious root cultures of Panax ginseng C.A. Meyer. In Vitro Cellular and Developmental Biology - Plant 2003, 39, 245–249. DOI: https://doi.org/10.1079/IVP2002397

Meyer H. J. & Staden J. V., The in vitro production of an anthocyanin from callus cultures of Oxalis linearis. Plant Cell Tiss Organ Cult 1995, 40, 55–58. DOI: https://doi.org/10.1007/BF00041119

Matsumoto T., Nishida K., Noguchi M. & Tamaki E., Some factors affecting the anthocyanin formation by Populus cells in suspension culture. Agricultural and Biological Chemistry 1973, 37, 561–567. DOI: https://doi.org/10.1080/00021369.1973.10860709

Weathers P. J., Bunk G. & McCoy M. C., The effect of phytohormones on growth and artemisinin production in Artemisia annua hairy roots. In Vitro Cellular and Developmental Biology - Plant 2005, 41, 47–53. DOI: https://doi.org/10.1079/IVP2004604

Bais H. P., Sudha G., George J. & Ravishankar G. A., Influence of exogenous hormones on growth and secondary metabolite production in hairy root cultures of Cichorium intybus L. CV. Lucknow local. In Vitro Cell.Dev.Biol.-Plant 2001, 37, 293–299. DOI: https://doi.org/10.1007/s11627-001-0052-8

Vanhala L., Eeva M., Lapinjoki S., Hiltunen R. & Oksman-Caldentey K.-M., Effect of growth regulators on transformed root cultures of Hyoscyamus muticus. Journal of Plant Physiology 1998, 153, 475–481. DOI: https://doi.org/10.1016/S0176-1617(98)80177-6

Chan L. K., Koay S. S., Boey P. L. & Bhatt A., Effects of abiotic stress on biomass and anthocyanin production in cell cultures of Melastoma malabathricum. Biological Research 2010, 43, 127–135. DOI: https://doi.org/10.4067/S0716-97602010000100014

Lui J. H. C. & Staba E. J., Effects of precursors on serially propagated Digitalis lanata leaf and root cultures. Phytochemistry 1979, 18, 1913–1916. DOI: https://doi.org/10.1016/S0031-9422(00)82701-6

Constabel F., Cell culture and somatic cell genetics of plants. Volume 4. Cell culture in phytochemistry, 1987. DOI: https://doi.org/10.1016/B978-0-12-715004-8.50007-7

Ellis B. E. & Towers G. H., Biogenesis of rosmarinic acid in Mentha. Biochemical Journal 1970, 118, 291–297. DOI: https://doi.org/10.1042/bj1180291

Fett-Neto A. G., Melanson S. J., Sakata K. & DiCosmo F., Improved growth and taxol yield in developing calli of Taxus cuspidata by medium composition modification. Nature Biotechnology 1993, 11, 731–735. DOI: https://doi.org/10.1038/nbt0693-731

Romagnoli L. G., Effects of ferulic acid treatment on growth and flavor development of cultured Vanilla planifolia cells. Food Biotechnology 1988, 2, 93–104. DOI: https://doi.org/10.1080/08905438809549678

Mulder-Krieger T., Verpoorte R., Svendsen A. B. & Scheffer J. J. C., Production of essential oils and flavours in plant cell and tissue cultures. A review. Plant Cell, Tissue and Organ Culture 1988, 13, 85–154. DOI: https://doi.org/10.1007/BF00034451

Furmanowa M., Olędzka H., Sykłowska-Baranek K., Józefowicz J. & Gieracka S., Increased taxane accumulation in callus cultures of Taxus cuspidata and Taxus x media by some elicitors and precursors. Biotechnology Letters 2000, 22, 1449–1452. DOI: https://doi.org/10.1023/A:1005611114628

Sykłowska-Baranek K., Pietrosiuk A., Kokoszka A. & Furmanowa M., Enhancement of taxane production in hairy root culture of Taxus x media var. Hicksii. Journal of Plant Physiology 2009, 166, 1950–1954. DOI: https://doi.org/10.1016/j.jplph.2009.05.001

Lindsey K. & Yeoman M. M., The synthetic potential of immobilised cells of Capsicum frutescens Mill cv. annuum. Planta 1984, 162, 495–501. DOI: https://doi.org/10.1007/BF00399914

Parr A. J., Robins R. J. & Rhodes M. J. C., Permeabilization of Cinchona ledgeriana cells by dimethylsulphoxide. effects on alkaloid release and long-term membrane integrity. Plant Cell Reports 1984, 3, 262–265. DOI: https://doi.org/10.1007/BF00269308

Brodelius P. & Nilsson K., Permeabilization of immobilized plant cells, resulting in release of intracellularly stored products with preserved cell viability. European J. Appl. Microbiol. Biotechnol. 1983, 17, 275–280. DOI: https://doi.org/10.1007/BF00508020

DiCosmo F. & Misawa M., Plant cell and tissue culture: Alternatives for metabolite production. Biotechnology Advances 1995, 13, 425–453. DOI: https://doi.org/10.1016/0734-9750(95)02005-N

Yadav P. R., Crop Biotechnology, Discovery Publishing House, 2006.

Papageorgiou V. P., Assimopoulou A. N., Couladouros E. A., Hepworth D. & Nicolaou K. C., The chemistry and biology of alkannin, shikonin, and related naphthazarin natural products. Angewandte Chemie - International Edition 1999, 38, 270–300. DOI: https://doi.org/10.1002/(SICI)1521-3773(19990201)38:3<270::AID-ANIE270>3.0.CO;2-0

Fujita Y., Hara Y., Suga C. & Morimoto T., Production of shikonin derivatives by cell suspension cultures of Lithospermum erythrorhizon - II. A new Medium for the production of shikonin derivatives. Plant Cell Reports 1981, 1, 61–63. DOI: https://doi.org/10.1007/BF00269273

Bhojwani S. S. & Razdan M. K., Plant Tissue Culture: Theory and Practice, Elsevier, 1996. DOI: https://doi.org/10.1016/S0928-3420(96)80002-4

Fujita Y., Shikonin: Production by plant (Lithospermum erythrorhizon) cell cultures. W: Bajaj, Y. P. S. (red.), Medicinal and Aromatic Plants I (s. 225-236), Springer Berlin Heidelberg 1988. DOI: https://doi.org/10.1007/978-3-642-73026-9_11

Fujita Y., Takahashi S. & Yamada Y., Selection of cell lines with high productivity of shikonin derivatives by protoplast culture of Lithospermum erythrorhizon cells. Agricultural and Biological Chemistry 1985, 49, 1755–1759. DOI: https://doi.org/10.1271/bbb1961.49.1755

Verpoorte R., Contin A. & Memelink J., Biotechnology for the production of plant secondary metabolites. Phytochemistry Reviews 2002, 1, 13–25. DOI: https://doi.org/10.1023/A:1015871916833

Kumar A., Ekavali, Chopra K., Mukherjee M., Pottabathini R. & Dhull D. K., Current knowledge and pharmacological profile of berberine: An update. European Journal of Pharmacology 2015, 761, 288–297. DOI: https://doi.org/10.1016/j.ejphar.2015.05.068

Hara Y., Yamagata H., Morimoto T., Hiratsuka J., Yoshioka T., Fujita Y. & Yamada Y., Flow cytometric analysis of cellular berberine contents in high- and low-producing cell lines of Coptis japonica obtained by repeated selection. Planta Medica 1989, 55, 151–154. DOI: https://doi.org/10.1055/s-2006-961910

Zenk M. H., Rüffer M., Kutchan T. M. & Galneder E., Biotechnological approaches to the production of isoquinoline alkaloids. W: Bock G., Marsh J. (red.), Applications of plant cell and tissue culture (Ciba Foundation Symposium 137) (s. 213-227), John Wiley & Sons, 2007. DOI: https://doi.org/10.1002/9780470513651.ch15

Morimoto T., Hara Y., Kato Y., Hiratsuka J., Yoshioka T., Fujita Y. & Yamada Y., Berberine production by cultured Coptis japonica cells in a one-stage culture using medium with a high copper concentration. Agricultural and Biological Chemistry 1988, 52, 1835–1836. DOI: https://doi.org/10.1271/bbb1961.52.1835

Matsubara K., Kitani S., Yoshioka T., Morimoto T., Fujita Y. & Yamada Y., High density culture of Coptis japonica cells increases berberine production. Journal of Chemical Technology and Biotechnology 1989, 46, 61–69. DOI: https://doi.org/10.1002/jctb.280460107

Lü J.-M., Yao Q. & Chen C., Ginseng compounds: An update on their molecular mechanisms and medical applications. Current Vascular Pharmacology 2009, 7, 293–302. DOI: https://doi.org/10.2174/157016109788340767

Lee C. H. & Kim J.-H., A review on the medicinal potentials of ginseng and ginsenosides on cardiovascular diseases. Journal of Ginseng Research 2014, 38, 161–166. DOI: https://doi.org/10.1016/j.jgr.2014.03.001

Son S. H., Choi S. M., Lee Y. H., Choi K. B., Yun S. R., Kim J. K., Park H. J., Kwon O. W., Noh E. W., Seon J. H. & Park Y. G., Large-scale growth and taxane production in cell cultures of Taxus cuspidata (Japanese yew) using a novel bioreactor. Plant Cell Reports 2000, 19, 628–533. DOI: https://doi.org/10.1007/s002990050784

Hibino K. & Ushiyama K., Commercial Production of Ginseng by Plant Tissue Culture Technology. W: Fu T.-J., Singh G. & Curtis W. R. (red.), Plant Cell and Tissue Culture for the Production of Food Ingredients(s. 215-224), Springer US 1999. DOI: https://doi.org/10.1007/978-1-4615-4753-2_18

Ramawat K. G., Biotechnology, Second Edition: Secondary Metabolites, CRC Press, 2007.

Paek K. Y., Murthy H. N., Hahn E. J. & Zhong J. J., Large scale culture of ginseng adventitious roots for production of ginsenosides. Advances in biochemical engineering/biotechnology 2009, 113, 151–176. DOI: https://doi.org/10.1007/10_2008_31

Malik S. Cusidó R. M., Mirjalili M. H., Moyano E., Palazon J. & Bonfill M., Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review. Process Biochemistry 2011, 46, 23–34. DOI: https://doi.org/10.1016/j.procbio.2010.09.004

Sykłowska-Baranek K., Pilarek M., Bonfill M., Kafel K. & Pietrosiuk A., Perfluorodecalin-supported system enhances taxane production in hairy root cultures of Taxus x media var. Hicksii carrying a taxadiene synthase transgene. Plant Cell, Tissue and Organ Culture 2015, 120, 1051–1059. DOI: https://doi.org/10.1007/s11240-014-0659-1

Meyer H.-P. & Schmidhalter D., Industrial scale suspension culture of living cells, John Wiley & Sons, 2014. DOI: https://doi.org/10.1002/9783527683321

Pistelli L., Giovannini A., Ruffoni B., Bertoli A. & Pistelli L., Hairy root cultures for secondary metabolites production. W: Giardi M. T., Rea G., Berra B., Bio-Farms for nutraceuticals (s. 167-184), Advances in experimental medicine and biology 2010. DOI: https://doi.org/10.1007/978-1-4419-7347-4_13

Hou J., Fu J., Zhang Z.-M. & Zhu H.-L., Biological activities and chemical modifications of caffeic acid derivatives. Fudan University Journal of Medical Sciences 2011, 38, 546–552.

Wu C.-H., Murthy H. N., Hahn E.-J. & Paek K.-Y., Large-scale cultivation of adventitious roots of Echinacea purpurea in airlift bioreactors for the production of chichoric acid, chlorogenic acid and caftaric acid. Biotechnol. Lett. 2007, 29, 1179–1182. DOI: https://doi.org/10.1007/s10529-007-9399-1

Fujita Y., Hara Y., Morimoto T. & Misawa M., Semisynthetic production of vinblastine involving cell cultures of Catharanthus roseus and chemical reaction. W: Nijkamp H. J. J., Van Der Plas L. H. W. & Van Aartrijk J. (red.), Progress in Plant Cellular and Molecular Biology (s. 738-743), Springer Netherlands 1990. DOI: https://doi.org/10.1007/978-94-009-2103-0_111

DiCosmo F. & Misawa M., Plant cell culture secondary metabolism toward industrial application, CRC Press, 1996.