PHOTOGENOTOXICITY IN IN VITRO STUDIES AND IN BACTERIAL TESTS IN THE YEARS 2013-2018 COMPARED WITH EARLIER PUBLICATIONS IN LIGHT OF CHANGES IN LEGAL REGULATIONS
DOI:
https://doi.org/10.56782/pps.52Keywords:
fotogenotoksyczność, fotomutagenność, genotoksyczność fotochemicznaAbstract
Photogenotoxicity, also known as photomutagenesis or photochemical genotoxicity, refers to DNA damage caused by the exposure of living organisms to light or to substances that, when irradiated, give rise to compounds capable of damaging the genetic material. The determination of photogenotoxicity of chemical compounds was the topic of numerous research papers in the past. However, guidelines of the European Medicines Agency updated in 2012 no longer required an in vitro determination of photogenotoxicity in preclinical studies. This decisions had a significant impact on the direction of photogenotoxicity research, as reported in the relevant scientific literature. The number of papers on new in vitro screening techniques decreased significantly. The subjects discussed most frequently in scientific articles over the past several years included attempts to identify the mechanisms of photochemical genotoxicity of selected compounds, as well as the photogenotoxicity of drug metabolites, nanoparticles, new drug formulations, and plant extracts. Another important group of publications focused on the search for new photosensitizers to be used in photodynamic therapy, illustrating the potential medical beneficial aspects of photogenotoxicity.
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