FOTOGENOTOKSYCZNOŚĆ W BADANIACH IN VITRO ORAZ TESTACH BAKTERYJNYCH W LATACH 2013-2018 W PORÓWNANIU DO LAT WCZEŚNIEJSZYCH W ŚWIETLE ZMIAN PRZEPISÓW PRAWNYCH

Anna Zgadzaj

doi:10.56782/pps.52

Published : 2018-08-20

Vol. 16 No. 3 (2018)

PHOTOGENOTOXICITY IN IN VITRO STUDIES AND IN BACTERIAL TESTS IN THE YEARS 2013-2018 COMPARED WITH EARLIER PUBLICATIONS IN LIGHT OF CHANGES IN LEGAL REGULATIONS

Anna Zgadzaj

DOI: https://doi.org/10.56782/pps.52

Abstract

Photogenotoxicity, also known as photomutagenesis or photochemical genotoxicity, refers to DNA damage caused by the exposure of living organisms to light or to substances that, when irradiated, give rise to compounds capable of damaging the genetic material. The determination of photogenotoxicity of chemical compounds was the topic of numerous research papers in the past. However, guidelines of the European Medicines Agency updated in 2012 no longer required an in vitro determination of photogenotoxicity in preclinical studies. This decisions had a significant impact on the direction of photogenotoxicity research, as reported in the relevant scientific literature. The number of papers on new in vitro screening techniques decreased significantly. The subjects discussed most frequently in scientific articles over the past several years included attempts to identify the mechanisms of photochemical genotoxicity of selected compounds, as well as the photogenotoxicity of drug metabolites, nanoparticles, new drug formulations, and plant extracts. Another important group of publications focused on the search for new photosensitizers to be used in photodynamic therapy, illustrating the potential medical beneficial aspects of photogenotoxicity.

Keywords:

fotogenotoksyczność, fotomutagenność, genotoksyczność fotochemiczna

Details

References

Statistics

Authors

Download files

PDF (Język Polski)

Citation rules

Zgadzaj, A. (2018). PHOTOGENOTOXICITY IN IN VITRO STUDIES AND IN BACTERIAL TESTS IN THE YEARS 2013-2018 COMPARED WITH EARLIER PUBLICATIONS IN LIGHT OF CHANGES IN LEGAL REGULATIONS. Prospects in Pharmaceutical Sciences, 16(3), 30–37. https://doi.org/10.56782/pps.52

Altmetric indicators

Cited by / Share

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License.

References

Muller L, Gocke E. The rise and fall of photomutagenesis. Mutation Research. 2013, 752, 67–71. DOI: https://doi.org/10.1016/j.mrrev.2013.02.002

Brendler-Schwaab S, Czich A, Epe B, Gocke E, Kaina B, Muller L, Pollet D, Utesch D. Photochemical genotoxicity: principles and test methods Report of a GUM task force. Mutation Research 2004, 566, 65–91. DOI: https://doi.org/10.1016/S1383-5742(03)00052-8

Meunier JR, Sarasin A, Marrot L. Photogenotoxicity of Mammalian Cells: A Review of the Different Assays for In Vitro Testing. Photochemistry and Photobiology. 2002, 75(5): 437–447. DOI: https://doi.org/10.1562/0031-8655(2002)075<0437:POMCAR>2.0.CO;2

Loprieno N. Guidelines for safety evaluation of cosmetics ingredients in the EC countries. Food and Chemical Toxicology. 1992, 30, 809–815. DOI: https://doi.org/10.1016/0278-6915(92)90084-X

Sargent EV, Travers JB. Examining the differences in current regulatory processes for sunscreens and proposed safety assessment paradigm. Regulatory Toxicology and Pharmacology. 2016, 79, 125-141. DOI: https://doi.org/10.1016/j.yrtph.2016.03.008

European Medicines Agency, Note for Guidance on Photosafety Testing, CPMP/SWP/398/01. 2002.

Dufor EK, Kumaravel T, Nohynek GJ, Kirkland D, Toutain H. Clastogenicity, photo-clastogenicity or pseudo-photo-clastogenicity: Genotoxic effects of zinc oxide in the dark, in pre-irradiated or simultaneously irradiated Chinese hamster ovary cells. Mutation Research. 2006, 607, 215–224. DOI: https://doi.org/10.1016/j.mrgentox.2006.04.015

European Medicines Agency. ICH Guidance S10 on Photosafety Evaluation of Pharmaceuticals. EMA/CHMP/ICH/752211/2012.

Butzbah K, Epe B. Photogenotoxicity of folic acid. Free Radical Biology and Medicine. 2013, 65, 821–827. DOI: https://doi.org/10.1016/j.freeradbiomed.2013.08.168

Seto Y, Inoue R, Kato M, Yamada S, Onoue S. Photosafety assessments on pirfenidone: Photochemical, photobiological, and pharmacokinetic characterization. Journal of Photochemistry and Photobiology, B: Biology. 2013, 120, 44–51. DOI: https://doi.org/10.1016/j.jphotobiol.2013.01.010

Dwivedi A, Pal MK, Tripathi AK, Yadav N, Majtuba SF, Pant MC, Singh SK, Mishra DP, Ray RS, Prabhu BHM. Role of type-II pathway in apoptotic cell death induction by photosensitized CDRI-97/78 under ambient exposure of UV-B. Toxicology Letters. 2013, 222, 122– 131. DOI: https://doi.org/10.1016/j.toxlet.2013.06.210

Soldevila S, Cuquerella MC, Lhiaubet-Vallet V, Edge R, Bosca F. Seeking the mechanism responsible for fluoroquinolone photomutagenicity: a pulse radiolysis, steady-state, and laser flash photolysis study. Free Radical Biology and Medicine. 2014, 67, 417–425. DOI: https://doi.org/10.1016/j.freeradbiomed.2013.11.027

Cizekova L, Grolmusova A, Ipothova Z, Barbierikova Z, Brezova V, Hunakova L, Imrich J, Janovec L, Dovinova I, Paulikova H. Novel 3,6-bis(imidazolidine)acridines as effective photosensitizers for photodynamic therapy. Bioorganic & Medicinal Chemistry. 2014, 22, 4684–4693. DOI: https://doi.org/10.1016/j.bmc.2014.07.013

Perucca P, Savio M, Cazzalini O, Mocchi R, Maccario C, Sommatis S, Ferraro D, Pizzala R, Pretali L, Fasani E, Albini A, Stivala LA. Structure–activity relationship and role of oxygen in the potential antitumour activity of fluoroquinolones in human epithelial cancer cells. Journal of Photochemistry and Photobiology, B: Biology. 2014, 140, 57–68. DOI: https://doi.org/10.1016/j.jphotobiol.2014.07.006

Zgadzaj A, Skrzypczak A, Welenc I, Ługowska A, Parzonko A, Siedlecka E, Sommer S, Sikorska K, Nałęcz-Jawecki G. Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions. Journal of Photochemistry and Photobiology, B: Biology. 2015, 144, 76–84. DOI: https://doi.org/10.1016/j.jphotobiol.2015.01.015

Amar SK, Goyal S, Dubey D, Srivastav AK, Chopra D, Singh J, Shankar J, Chaturvedi RK, Ray RS. Benzophenone 1 induced photogenotoxicity and apoptosis via release of cytochrome c and Smac/DIABLO at environmental UV radiation. Toxicology Letters. 2015, 239, 182–193. DOI: https://doi.org/10.1016/j.toxlet.2015.09.024

Feruszowa J, Imreova P, Bodnarova K, Sevcovicova A, Kyzek S, Chalupa I, Galova E, Miadokova E. Photoactivated hypericin is not genotoxic. General Physiology and Biophisics. 2016, 35, 230-230. DOI: https://doi.org/10.4149/gpb_2015045

Goyal S, Amar AK, Dwivedi A, Mujtaba SF, Kushwaha HN, Chopra D, Pal MK, Singh D, Chaturvedi RK, Ray RS. Photosensitized 2-amino-3-hydroxypyridine-induced mitochondrial apoptosis via Smac/DIABLO in human skin cells. Toxicology and Applied Pharmacology. 2016, 297, 12–21. DOI: https://doi.org/10.1016/j.taap.2016.02.022

Ibrahim T, El Rouby MN, Al-Sherbini EAM, El Noury AHE, Morsy ME. Photodecomposition, photomutagenicity and photocytotoxicity of retinyl palmitate under He–Ne laser photoirradiation and its effects on photodynamic therapy of cancer cells in vitro. Photodiagnosis and Photodynamic Therapy. 2016, 13, 316–322. DOI: https://doi.org/10.1016/j.pdpdt.2015.09.002

Palumbo F, Garcia-Lainez G, Limones-Herrero D, Coloma MD, Escobar J, Jimenez MC, Miranda MA, Andreu I. Enhanced photo(geno)toxicity of demethylated chlorpromazine metabolites. Toxicology and Applied Pharmacology. 2016, 313, 131–137. DOI: https://doi.org/10.1016/j.taap.2016.10.024

Singh J, Dwivedi A, Majtuba SF, Singh KP, Pal MK, Chopra D, Goyal S, Srivastav AK, Dubey D, Gupta SK, Haldar C, Ray RS. Ambient UV-B exposure reduces the binding of ofloxacin with bacterial DNA gyrase and induces DNA damage mediated apoptosis. The International Journal of Biochemistry & Cell Biology. 2016, 73, 111–126. DOI: https://doi.org/10.1016/j.biocel.2016.01.001

Srivastav K, Majtuba SF, Dwivedi A, Amar SK, Goyal S, Verma A, Kushwaha HN, Chaturvedi RK, Ray RS. Photosensitized rose Bengal-induced phototoxicity on human melanoma cell line under natural sunlight exposure. Journal of Photochemistry & Photobiology, B: Biology. 2016, 156, 87–99. DOI: https://doi.org/10.1016/j.jphotobiol.2015.12.001

Fernandes AS, Mazzei JL, Oliveira CG, Evangelista H, Marques MRC, Ferraz ERA, Felzenszwalb I. Protection against UV-induced toxicity and lack of mutagenicity of Antarctic Sanionia uncinate. Toxicology. 2017, 376, 126–136. DOI: https://doi.org/10.1016/j.tox.2016.05.021

Horai Y, Ando Y, Kimura S, Arimoto-Kobayashi S. Mutation spectrum resulting in M13mp2 phage DNA exposed to N-nitrosoproline with UVA irradiation. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2017, 821, 1–4. DOI: https://doi.org/10.1016/j.mrgentox.2017.06.003

Dubey D, Chopra D, Singh J, Srivastav AK, Kumari S, Verma A, Ray RS. Photosensitized methyl paraben induces apoptosis via caspase dependent pathway under ambient UVB exposure in human skin cells. Food and Chemical Toxicology. 2017, 108, 171-185. DOI: https://doi.org/10.1016/j.fct.2017.07.056

Abo-Zeid MAM, Abo-Elfadl MT, Mostafa SM. Photodynamic therapy using 5-aminolevulinic acid triggered DNA damage of adenocarcinoma breast cancer and hepatocellular carcinoma cell lines. Photodiagnosis and Photodynamic Therapy. 2018, 21, 351–356. DOI: https://doi.org/10.1016/j.pdpdt.2018.01.011

Amar SK, Goyal S, Srivastav AK, Chopra D, Ray RS. Combined effect of Benzophenone-2 and ultraviolet radiation promote photogenotoxicity and photocytotoxicity in human keratinocytes. Regulatory Toxicology and Pharmacology. 2018, 95, 298–306. DOI: https://doi.org/10.1016/j.yrtph.2018.04.003

Garcia-Lainez G, Martinez-Reig AM, Limonez-Herrero D, Jimenez MC, Miranda MA, Andreu I. Photo(geno)toxicity changes associated with hydroxylation of the aromatic chromophores during diclofenac metabolism. Toxicology and Applied Pharmacology. 2018, 341, 51–55. DOI: https://doi.org/10.1016/j.taap.2018.01.005

Genc H, Barutca B, Koparal AT, Ozogut U, Sahin Y, Suvaci E. Biocompatibility of designed MicNo-ZnO particles: Cytotoxicity, genotoxicity and phototoxicity in human skin keratinocyte cells. Toxicology in Vitro. 2018, 47, 238–248. DOI: https://doi.org/10.1016/j.tiv.2017.12.004

Singh J, Srivastav AK, Mandal P, Chandra S, Dubey D, Dwivedi A, Chopra D, Tripathi A, Ray RS. Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. Journal of Photochemistry & Photobiology, B: Biology. 2018, 178, 593–605. DOI: https://doi.org/10.1016/j.jphotobiol.2017.12.014

Zgadzaj A, Kornacka J, Jastrzębska A, Parzonko A, Sommer S, Nałęcz-Jawecki G. Development of photoprotective, antiphototoxic, and antiphotogenotoxic formulations of ocular drugs with fluoroquinolones. Journal of Photochemistry & Photobiology, B: Biology. 2018, 178, 201–210. DOI: https://doi.org/10.1016/j.jphotobiol.2017.11.011

Onoue S, Igarashi N, Kitagawa F, Otsuka K, Tsuda Y. Capillary electrophoretic studies on the photogenotoxic potential of pharmaceutical substances. Journal of Chromatography A. 2008, 1188, 50–56. DOI: https://doi.org/10.1016/j.chroma.2007.09.084

Marrot L, Belaidi JP, Chaubo C, Meunier JR, Peres P, Agapakis-Causse C. Fluoroquinolones as chemical tools to define a strategy for photogenotoxicity in vitro assessment. Toxicology in Vitro. 2001, 15, 131-142. DOI: https://doi.org/10.1016/S0887-2333(01)00004-2

Seto Y, Ochi M, Onoue S, Yamada S. High-throughput screening strategy for photogenotoxic potential of pharmaceutical substances using fluorescent intercalating dye. Journal of Pharmaceutical and Biomedical Analysis. 2010, 52, 781–786. DOI: https://doi.org/10.1016/j.jpba.2010.02.029

Miolo G, Viola G, Vedaldi D, Dall’Acqua F, Fravolini A, Tabarrini O, Cacchetti V. In vitro phototoxic properties of new 6-desfluoro and 6-fluoro-8-methylquinolones. Toxicology in Vitro. 2002, 16, 683–693. DOI: https://doi.org/10.1016/S0887-2333(02)00093-0

Kim MJ, Pal S, Naoghare PK, Song JM. Monitoring the (photo)genotoxicity of photosensitizer drugs: Direct quantitation of single-strand breaks in deoxyribonucleic acid using an oligonucleotide chip. Analytical Biochemistry. 2008, 382, 40–47. DOI: https://doi.org/10.1016/j.ab.2008.07.015

Martinez L, Chignell CF. Photocleavage of DNA by the fluoroquinolone antibacterials. Journal of Photochemistry and Photobiology, B: Biology. 1998, 45, 51-59. DOI: https://doi.org/10.1016/S1011-1344(98)00160-2

Gocke E, Chetelat AA, Csato M, McGarvevy DJ, Jakob-Roetne R, Kirchner S, Muster W, Potthast M, Widmar U. Phototoxicity and photogenotoxicity of nine pyridone derivatives. Mutation Research. 2003, 535, 43–54. DOI: https://doi.org/10.1016/S1383-5718(02)00283-8

Gocke E, Albertini S, Chetelat AA, Kirchner S, Muster W. The photomutagenicity of fluoroquinolones and other drugs. Toxicology Letters. 1998, 102-103, 375-381. DOI: https://doi.org/10.1016/S0378-4274(98)00235-5

Tchou J, Kasai H, Shibutani S, Chung MH, Laval J, Grollman AP, Nishimura S. 8-Oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity. Proceedings of the National Academy of Sciences of the USA. 1991, 88, 4690–4694. DOI: https://doi.org/10.1073/pnas.88.11.4690

Karakaya A, Jaruga P, Bohr VA, Grollman AP, Dizdaroglu M. Kinetics of excision of purineles ions from DNA by Escherichia coli Fpg protein. Nucleic Acids Research. 1997, 25, 474–479. DOI: https://doi.org/10.1093/nar/25.3.474

Tretyakova NY, Wishnok JS, Tannenbaum SR. Peroxynitrite-induced secondary oxidative lesions at guanine nucleobases: chemical stability and recognition by the Fpg DNA repair enzyme. Chemical Research in Toxicology. 2000, 13, 658–664. DOI: https://doi.org/10.1021/tx000083x

Asahara H, Wistort PM, Bank JF, Bakerian RH, Cunningham RP. Purification and characterization of Escherichia coli endonuclease III from the cloned nth gene. Biochemistry. 1989, 28, 4444–4449. DOI: https://doi.org/10.1021/bi00436a048

Nakabeppu Y, Yamashita K, Sekiguchi M. Purification and characterization of normal and mutant forms of T4 endonuclease V. Journal of Biological Chemistry. 1982, 257, 2556–2562. DOI: https://doi.org/10.1016/S0021-9258(18)34960-3

Toolaram AP, Haddad T, Leder C, Kummere K. Initial hazard screening for genotoxicity of photo-transformation products of ciprofloxacin by applying a combination of experimental and in-silico testing. Environmental Pollution. 2016, 211, 148-156. DOI: https://doi.org/10.1016/j.envpol.2015.12.040

Skrzypczak A, Przystupa N, Zgadzaj A, Parzonko A, Sykłowska-Baranek K, Paradowska K, Nałęcz-Jawecki G. Antigenotoxic, anti-photogenotoxic and antioxidant activities of natural naphthoquinone shikonin and acetylshikonin and Arnebia euchroma callus extracts evaluated by the umu-test and EPR method. Toxicology in Vitro. 2015, 30, 364–372. DOI: https://doi.org/10.1016/j.tiv.2015.09.029

Rojkiewicz M, Kozik W, Czapka M, Jarzembek K, Zięba G, Kuś P, Kozik V. Fotodynamiczna terapia nowotworów. Problemy Ekologii. 2010, 14(4), 196-204.

Nowak-Stępniowska A, Pergoł P, Padzik-Graczyk A. Metoda fotodynamiczna diagnostyki i leczenia nowotworów – mechanizmy i zastosowania. Postępy Biochemii. 2013, 59(1), 53-63.

Oda Y. Development and progress for three decades in umu test systems. Genes and Environment. 2016, 38(24), 2-14. DOI: https://doi.org/10.1186/s41021-016-0054-8

Skrzypczak A, Bonisławska A, Nałęcz-Jawecki G, Kobylińska J, Koszyk I, Demkowicz-Dobrzański K, Sawicki J. Short-term bacterial tests as a convenient method for screening assessment of photogenotoxic properties of pharmaceuticals. Fresenius Environmental Bulletin. 2010, 19, 147-153.

Snyder RD, Cooper CS. Photogenotoxicity of fluoroquinolones in Chinese hamster V79 cells: dependency on active topoisomerase II. Photochemistry and Photobiology. 1999, 69, 288–293. DOI: https://doi.org/10.1562/0031-8655(1999)069<0288:POFICH>2.3.CO;2

Kersten B, Kasper P, Brendler-Schwaab SY, Muller L. Effects of visible light absorbing chemicals in the photo-micronucleus test in Chinese hamster V79 cells. Environmental Mutagen Research. 2001, 23, 97–102.

Toyooka T, Ishihama M, Ibuki Y. Phosphorylation of Histone H2AX Is a Powerful Tool for Detecting Chemical Photogenotoxicity. Journal of Investigative Dermatology. 2011, 131, 1313–1321. DOI: https://doi.org/10.1038/jid.2011.28

Kersten B, Zhang J, Brendler-Schwaab SY, Kasper P, Muller L. The application of the micronucleus test in Chinese hamster V79 cells to detect drug-induced photogenotoxicity. Mutation Research. 1999, 445, 55–71. DOI: https://doi.org/10.1016/S1383-5718(99)00143-6

Struwe M, Greulich K, Suter W, Plappert-Helbing U. The photo comet assay—A fast screening assay for the determination of photogenotoxicity in vitro. Mutation Research. 2007, 632, 44–57. DOI: https://doi.org/10.1016/j.mrgentox.2007.04.014

Kersten B, Kasper P, Brendler-Schwaab SY, Muller L. Use of the photo-micronucleus assay in Chinese hamster V79 cells to study photochemical genotoxicity. Mutation Research. 2002, 519, 49–66. DOI: https://doi.org/10.1016/S1383-5718(02)00113-4

Marrot L, Laberussiat A, Perez P, Meunier JR. Use of the yeast Saccharomyces cerevisiae as a pre-screening approach for assessment of chemical-induced phototoxicity. Toxicology in Vitro. 2006, 20, 1040–1050. DOI: https://doi.org/10.1016/j.tiv.2006.01.008