DIETARY SOURCES AND BENEFICIAL HEALTH EFFECTS OF CONJUGATED LINOLEIC ACIDS (CLA)
DOI:
https://doi.org/10.56782/pps.61Keywords:
conjugated linoleic acid (CLA), dairy products, atherogenesis, tumoursAbstract
Dairy fat is one of the most complex of natural fats. It contains over 400 different fatty acids, most of them (>98%) as triglycerides, and is the main dietary source of conjugated linoleic acids (CLA). CLA is a group of positional and geometric isomers of linoleic acid containing a conjugated double bond system. Rumenic acid (cis-9, trans-11 octadecadienoic acid) is the predominant CLA isomer that accounts for 80–90% of the total CLA amount in dairy fat of poligastric animals. Multiple publications suggest that rational dietetics should assure an adequate supply of CLA, which have many beneficial health effects, including prevention of cancer and diabetes, and antiinflammatory and antiatherogenic properties. Milk and dairy products are the main dietary source of CLA. This review focuses on the health effects of conjugated linoleic acid and also summarizes the CLA content of common dairy products.
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References
Farmakologia. Podstawy farmakoterapii. red. Kostowski W., Wyd. II poprawione, Wydawnictwo Lekarskie PZWL, Warszawa 2001; 234.
Obiedziński M.W., Bartnikowska E., Grześkiewicz S.: Występowanie sprzężonych dienów kwasu linolowego w produktach żywnościowych. Sympozjum „Olej z nasion wiesiołka i inne oleje, zawierające kwasy tłuszczowe n-6 lub n-3 w profilaktyce i terapii”, 1998; 47-52.
Turpeinen A.M., Mutagen M., Aro A. et al.: Bioconversion of Vaccenic Acid to Conjugated Linoleic Acid in Humans. Am. J. Clin. Nutr., 2002; 76:504-510. DOI: https://doi.org/10.1093/ajcn/76.3.504
Mosley E.E., Mc Guire M.K., Williams J.E., Mc Guide M.A.: Cis-9, trans-11 Conjugated Linoleic Acid Is Synthesized from Vaccenic Acid in Lactating Women. J. Nutr., 2006; 136:2297-2301. DOI: https://doi.org/10.1093/jn/136.9.2297
Pariza M.W., Park Y., Cook M.E.: The biologically active isomers of conjugated linoleic acid, Progress In Lipid Research, 2001; 40:283-293. DOI: https://doi.org/10.1016/S0163-7827(01)00008-X
Pariza M.W., Asheer S.H., Chu I.S., Lund D.H.: Effects of temperature and time on mutagen formation in pan-fried hamburger. Cancer Lett., 1979; 7:63-9. DOI: https://doi.org/10.1016/S0304-3835(79)80097-X
Pariza M.W., Hargraves W.A.: A beef-derived mutagenesis modulator inhibits initiation of mouse epidermal tumors by 7,12-dimethylbenz[a]anthracene. Carcinogenesis, 1985; 6:591-593. DOI: https://doi.org/10.1093/carcin/6.4.591
Masso-Welch P.A., Zangani D., Ip C., Vaughan M.M., Shoemaker S., Ramirez R.A., Ip. M.M: Inhibition of Angiogenesis by the Cancer Chemopreventive Agent Conjugated Linoleic Acid, Caner Res., 2002; 62: 4383-4389.
Pryor M., Slattery M.L., Robinson L.M., Egger M: Adolescent diet and breast cancer in Utah, Cancer Res., 1989; 49: 2161-2167.
Frazie A.L., Ryan C.T., Rockett H., Willett W.C., Colditz G.A.: Adolescent diet and risk of breast cancer, Breast Cancer Res., 2003; 5: R59-R64. DOI: https://doi.org/10.1186/bcr583
Thompson H., Zhu Z.J., Banni S., Darcy K., Lotus T., Ip C.: Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk, Cancer Res., 1997; 57: 5067-5072.
National Research Council (NRC): Carcinogens and Anticarcinogens in the Human Diet, National Academy Press, Washington DC, 1996
Munday J.S., Thompson K.G., James A.C.: Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model. Br. J. Nutr., 1999; 81:251-255. DOI: https://doi.org/10.1017/S0007114599000458
Nestel P., Fujii A., Allen T.: The cis-9,trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentration but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice. Atherosclerosis, 2006; 189:282-287. DOI: https://doi.org/10.1016/j.atherosclerosis.2005.12.020
Toomey S., Harhen B., Roche H.M. et al.: Profound resolution of early atherosclerosis with conjugated linoleic acid. Atherosclerosis, 2006; 187:40-49. DOI: https://doi.org/10.1016/j.atherosclerosis.2005.08.024
Arbonés-Mainar J.M., Navarro M.A., Guzmán M.A. et al.: Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice. Atherosclerosis, 2006; 189:318-327. DOI: https://doi.org/10.1016/j.atherosclerosis.2006.01.015
Kritchevsky D., Tepper S.A., Wright S. et al.: Influence of Conjugated Linoleic Acid (CLA) on Establishment and Progression of Atherosclerosis in Rabbits. J. Am. Coll. Nutr., 2000; 19(4):472S-477S. DOI: https://doi.org/10.1080/07315724.2000.10718950
Kritchevsky D., Tepper S.A., Wright S., Czarnecki S.K.: Influence of graded levels of conjugated linoleic acid (CLA) on experimental atherosclerosis in rabbits. Nutr. Res., 2002; 22:1275-1279. DOI: https://doi.org/10.1016/S0271-5317(02)00432-3
Kritchevsky D., Tepper S.A., Wright S. et al.: Conjugated Linoleic Acid Isomer Effects in Atherosclerosis: Growth and Regression of Lesions. Lipids, 2004; 39:611-616. DOI: https://doi.org/10.1007/s11745-004-1273-8
Nagao K., Inoue N., Wang Y.-M. et al.: The 10trans,12cis isomer of conjugated linoleic acid suppress the development of hypertension in Otsuka Long-Evans Tokushima fatty rats. Biochem. Biophys. Res. Commun., 2003; 306:134-138. DOI: https://doi.org/10.1016/S0006-291X(03)00929-X
Inoue N., Nagao K., Hirata J. et al.: Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Biochem. Biophys. Res. Commun., 2004; 323:679-684. DOI: https://doi.org/10.1016/j.bbrc.2004.08.139
Deckere E.A.M., van Amelsvoort J.M.M., Neill G.P., Jones P.: Effects of conjugated linoleic acid (CLA) isomers on lipid levels and peroxisome proliferation in the hamster. Br. J. Nutr., 1999; 82:309-317. DOI: https://doi.org/10.1017/S0007114599001518
Gavino V.C., Gavio G., Leblanc M.-J. Tuchweber B.: An isomeric Mixture of Conjugated Linoleic Acids But Not Pure cis-9,trans-11-Octadecadienoic Acid Affects Body Weight gain and Plasma Lipids in Hamsters. J. Nutr., 2000; 130:27-29. DOI: https://doi.org/10.1093/jn/130.1.27
Navarro V., Zabala A., Macarulla M.T. et al.: Effects of conjugated linoleic acid on body fat accumulation and serum lipids in hamsters fed an atherogenic diet. J. Physiol. Biochem., 2003; 59(3):193-200. DOI: https://doi.org/10.1007/BF03179915
Valeille K., Gripois D., Bloquit M.-F. et al.: Lipid atherogenic risk markers can be more favorably influenced by the cis-9,trans-11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters. Br. J. Nutr., 2004; 91:191-199. DOI: https://doi.org/10.1079/BJN20031057
Lock A.L., Horne C.A.M., Bauman D.E., Salter A.M.: Butter Naturally Enriched in Conjugated Linoleic Acid and Vaccenic Acid Alters Tissue Fatty Acids and Improves the Plasma Lipoprotein Profile in Cholesterol-Fed Hamsters. J. Nutr., 2005; 135:1934-1939. DOI: https://doi.org/10.1093/jn/135.8.1934
Valeille K., Férézou J., Amsler G. et al.: A cis-9,trans-11-conjugated Linoleic acid-rich oil reduces the outcome of atherogenic process in hyperlipidemic hamster. Am. J. Physiol. Heart Circ. Physiol., 2005; 289:H652-H659. DOI: https://doi.org/10.1152/ajpheart.00130.2005
Valeille K., Férézou J., Parquet M. et al.: The Natural Concentration of the Conjugated Linoleic Acid, cis-9,trans-11, in Milk Fat Has Antiatherogenic Effects in Hyperlipidemic Hamster. J. Nutr., 2006; 136:1305-1310. DOI: https://doi.org/10.1093/jn/136.5.1305
Mitchell P.L., Langille M.A., Currie D.L., McLeod R.S.: Effect of conjugated linoleic acid isomers on lipoproteins and atherosclerosis in the Syrian Golden hamster. Biochim. Biophys. Acta, 2005; 1734:269-276. DOI: https://doi.org/10.1016/j.bbalip.2005.04.007
Wilson T.A., Nicolosi R.J., Saati A. et al.: Conjugated Linoleic Acid Isomers Reduce Blood Cholesterol Levels but Not Aortic Cholesterol Accumulation in Hypercholesterolemic Hamster. Lipids, 2006; 41:41-48. DOI: https://doi.org/10.1007/s11745-006-5068-8
Navarro V., Macarulla M.T., Fernández-Quintela A. et al.: Effects of trans-10,cis-12 conjugated Linoleic acid on cholesterol metabolism in hypercholesterolaemic hamsters. Eur. J. Nutr., 2007; 46:213-219. DOI: https://doi.org/10.1007/s00394-007-0653-z
Moya-Camarena S.Y., Belury M.A.: Species Differences in the Metabolism and Regulation of Gene Expression by Conjugated Linoleic Acid. Nutr. Rev., 1999; 57(11):336-340. DOI: https://doi.org/10.1111/j.1753-4887.1999.tb06910.x
Biochemia Harpera. Wyd. V, Wydawnictwo Lekarskie PZWL, Warszawa 2004; 354.
Mougios V., Matsakas A., Petridou A. et al.: Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. J. Nutr. Biochem., 2001; 12:585-594. DOI: https://doi.org/10.1016/S0955-2863(01)00177-2
Tricon S., Burge G.C., Kew S. et al.: Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans. Am. J. Clin. Nutr., 2004; 80:614-620. DOI: https://doi.org/10.1093/ajcn/80.3.614
Tricon S., Burge G.C., Jones E.L. et al.: Effects of diary products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood profile in healthy middle-aged men. Am. J. Clin. Nutr., 2006; 83:744-753. DOI: https://doi.org/10.1093/ajcn/83.4.744
Risérus U., Smedman A., Basu S., Vessby B.: Metabolic effects of conjugated linoleic acid in humans: the Swedish experience. Am. J. Clin. Nutr., 2004; 79:1146S-1148S. DOI: https://doi.org/10.1093/ajcn/79.6.1146S
Moloney F., Yeow T.-P., Mullen A. et al.: Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patient with type 2 diabetes mellitus. Am. J. Clin. Nutr., 2004; 80:887-895. DOI: https://doi.org/10.1093/ajcn/80.4.887
Taylor J.S.W., Williams S.R.P., Rhys R. et al.: Conjugated Linoleic Acid Impairs Endothelial Function. Arterioscler. Thromb. Vasc. Biol., 2006; 26:307-312. DOI: https://doi.org/10.1161/01.ATV.0000199679.40501.ac
Tokarz A., Białek A., Stawarska A., Gołębiowska L.: Porównanie zawartości sprzężonych dienów kwasu linolowego – CLA w masłach dostępnych na rynku warszawskim w 2006 roku. Żywienie człowieka i metabolizm, 2007; 1/2:118-127.
Tokarz A., Białek A., Krasowska M.: Ocena zawartości kwasu żwaczowego (cis-9, trans-11 CLA) w wybranych gatunkach serów. Bromat. Chem. Toksykol., 2008; 3: 580–584.
Precht D., Molketin J.: Analysis and seasonal variation of conjugated linoleic acid and further cis-/trans- isomers of C18:1 and C18:2 in bovine milk fat, Kieler Milchwirtschaftliche Forschungsberichte, 1999; 51:63-78.
Ledoux M., Chardigny J. - M., Darbois M., Soustre Y., SebedioJ. - L., Laloux L.: Fatty acid composition of French butters, with special emphasis on conjugated linoleic acid (CLA) isomers, J. Food Comp. Anal., 2005; 18:409–425. DOI: https://doi.org/10.1016/j.jfca.2004.01.001
Jensen R.G.: The Composition of Bovine Milk Lipids: January 1995 to December 2000, J. Dairy Sci., 2002; 85:295–302. DOI: https://doi.org/10.3168/jds.S0022-0302(02)74079-4
Tanaka K.: Occurrence of conjugated linoleic acid in ruminant products and its physiological functions, Animal Science Journal, 2005; 76:291-303. DOI: https://doi.org/10.1111/j.1740-0929.2005.00268.x
Sieber R., Collomb M., Aeschlimann A., Jelen P., Eyer H.: Impact of microbal cultures on conjugated linoleic acid in dairy products – a review. International Dairy Journal, 2004; 14:1-15. DOI: https://doi.org/10.1016/S0958-6946(03)00151-1
Lavillonniere F., Martin J. C., Bougnoux P., Sebedio J.-L.: Analysis of Conjugated Linoleic Acid and Content in French Cheeses. JAOCS, 1998; 75, 3:343-352. DOI: https://doi.org/10.1007/s11746-998-0051-6
Zlatanos S., Laskaridis K., Feist C., Sagredos A.: CLA content and fatty acid composition of Greek Feta and hard cheeses. Food Chemistry, 2002; 78:471-477. DOI: https://doi.org/10.1016/S0308-8146(02)00159-0
McGuire M. A., McGuire M. K.: Conjugated linoleic acid (CLA): A ruminant fatty acid with beneficial effects on human health. Proceeding of the American Society of Animal Science, 1999; http://www.asas.org/symposia/9899proc/0938.pdf. DOI: https://doi.org/10.2527/jas2000.00218812007700ES0033x
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