ISOPROSTANES - NEW BIOMARKERS IN LIPID PEROXIDATION IN VIVO
DOI:
https://doi.org/10.56782/pps.48Keywords:
isoprostanes, biomarkers, oxidative stressAbstract
The discovery of isoprostanes, which are products of non-enzymatic lipid peroxidation, resulted in the research on the new role of free radicals in physiology and pathophysiology. Isoprostane quantitative analysis, by use of physical and immunological methods, is a great achievement in the evaluation of free radical impact on many diseases in human. Isoprostanes occur commonly in biological liquids such as urine, blood, cerebro-spinal fluid and in the air breathed out. For that reason attempts are made to apply isoprostanes in the diagnosis of chronic diseases, which may be caused by oxidative stress.
Quantification of isoprostanes also gives the possibilities to optimize the diet by supporting proper amounts of antioxidants and polyunsaturated fatty acids and by supplementation with beneficial components.
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