OCHRONNA ROLA KWASU α-LIPONOWEGO W MIAŻDŻYCY I CHOROBACH SERCOWO-NACZYNIOWYCH

Dominika Łacheta; Wioletta Olejarz

doi:10.56782/pps.24

Published : 2019-08-07

Vol. 17 No. 8 (2019)

OCHRONNA ROLA KWASU α-LIPONOWEGO W MIAŻDŻYCY I CHOROBACH SERCOWO-NACZYNIOWYCH

Dominika Łacheta

Wioletta Olejarz

DOI: https://doi.org/10.56782/pps.24

Abstract

Kwas α-liponowy (α-LA) jest naturalnym antyoksydantem występującym w żywności w postaci lipolizyny. Zarówno α-LA, jak i jego zredukowana postać DHLA (kwas dihydroliponowy) hamują produkcję reaktywnych form tlenu (ROS) i redukują szkodliwe ich działanie, mają zdolność chelatowania jonów metali przejściowych oraz regeneracji innych przeciwutleniaczy. Oprócz efektu antyoksydacyjnego wykazują także działanie przeciwzapalne. Stres oksydacyjny i stan zapalny odgrywają kluczową rolę w patogenezie miażdżycy i chorób sercowo-naczyniowych. α-LA obniża poziom lipidów we krwi, zapobiega oksydacyjnym modyfikacjom cząsteczki LDL i hamuje tworzenie blaszki miażdżycowej. Jądrowy czynnik transkrypcyjny kappa B (NF-κB) przyczynia się do rozwoju miażdżycy poprzez aktywację genów prozapalnych, natomiast α-LA hamuje odpowiedź zapalną indukowaną przez NF-κB poprzez redukcję stresu oksydacyjnego, hamowanie ekspresji cząsteczek adhezyjnych oraz proliferacji i migracji komórek mięśni gładkich naczyń. Ponadto, suplementacja α-LA może obniżać ciśnienie krwi. W pracy dokonano przeglądu badań dotyczących roli α-LA w patogenezie miażdżycy i chorób sercowo-naczyniowych.

Keywords:

kwas α-liponowy, antyoksydant, miażdżyca, choroby sercowo-naczyniowe

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Łacheta, D., & Olejarz, W. (2019). OCHRONNA ROLA KWASU α-LIPONOWEGO W MIAŻDŻYCY I CHOROBACH SERCOWO-NACZYNIOWYCH. Prospects in Pharmaceutical Sciences, 17(8), 43–50. https://doi.org/10.56782/pps.24

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Dominika Łacheta

dominika.lacheta@wum.edu.pl

Affiliation:

Katedra Biochemii i Chemii Klinicznej, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej oraz Centrum Badań Przedklinicznych, Warszawski Uniwersytet Medyczny, ul. Banacha 1, 02-097 Warszawa Poland

Wioletta Olejarz

Affiliation: