MECHANIZMY PROWADZĄCE DO ANGIOGEGNEZY  W NOWOTWORACH

Magdalena Tchorzewska; Malwina Kowalik; Adrianna Kuliś; Wioletta Olejarz

doi:10.56782/pps.20

Published : 2019-08-07

Vol. 17 No. 10 (2019)

MECHANISMS LEADING TO ANGIOGEGNESIS IN CANCERS

Magdalena Tchorzewska

Malwina Kowalik

Adrianna Kuliś

Wioletta Olejarz

DOI: https://doi.org/10.56782/pps.20

Abstract

Angiogenesis is a multi-stage process which involves the formation of capillaries from the preexisting vasculature. There can be distinguished a number of functions and substances that stimulate and inhibit this process, known as an angiogenesis stimulator or inhibitor. Vascular endothelial growth factor (VEGF), are the main chemical signals that induce blood formation. Among many angiogenesis inhibitors, angiostatin, endostatin and thrombospondin play an important role. It is very important to keep a balance between activators and inhibitors. Large amount of angiogenesis stimulator may cause progression to malignant cancer. Tumor angiogenesis allows for supply of oxygen, nutrients, growth factors, and tumor dissemination to distant sites. Inhibition of angiogenesis appears to be an important prognostic factor in the treatment of cancer.

Keywords:

angiogenesis, VEGF, angiopoietin, cancer, anti-angiogenic therapy

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Tchorzewska, M., Kowalik, M., Kuliś, A., & Olejarz, W. (2019). MECHANISMS LEADING TO ANGIOGEGNESIS IN CANCERS. Prospects in Pharmaceutical Sciences, 17(10), 60–65. https://doi.org/10.56782/pps.20

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Magdalena Tchorzewska

Affiliation:

Zakład Biochemii i Farmakogenomiki, Warszawski Uniwersytet Medyczny, Banacha 1, 02-097 Warszawa; Centrum Badań Przedklinicznych Warszawskiego Uniwersytetu Medycznego, Banacha 1b, 02-097 Warszawa Poland

Malwina Kowalik

Affiliation:

Adrianna Kuliś

Affiliation:

Zakład Biochemii i Farmakogenomiki, Warszawski Uniwersytet Medyczny,Banacha 1, 02-097 Warszawa; Centrum Badań Przedklinicznych Warszawskiego Uniwersytetu Medycznego, Banacha 1b, 02-097 Warszawa Poland

Wioletta Olejarz

wioletta.olejarz@wum.edu.pl

MECHANISMS LEADING TO ANGIOGEGNESIS IN CANCERS

Magdalena Tchorzewska

Malwina Kowalik

Adrianna Kuliś

Wioletta Olejarz

Abstract

Keywords:

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