Published : 2024-05-06

Drugs and other chemical substances inducing diabetes – review of the literature

Paulina Oleksa

Daria Żuraw

Kacper Jasiński

Mateusz Sobczyk

Mikołaj Porzak

Alicja Sodolska

Karolina Haczkur-Pawłowska

Abstract

A Type 3 diabetes, classified as secondary diabetes, includes drug-induced or chemical-induced forms of diabetes. We distinguish many types of drugs that can induce diabetes, among others commonly used glucocorticosteroids, β-blockers and diuretics, antidepressants and antipsychotics, statins, or antiviral drugs.

We aimed to evaluate the impact of chosen drugs and other chemical substances on glycemic control, to analyse the mechanisms of development of drug-induced diabetes and to propose the therapeutic procedures. We conducted the literature review using the Pubmed and Google Scholar. We analysed reviews, systematic reviews, meta-analysis, randomized controlled trials, clinical trials, and observational studies published from 2013 to 2024.

Mechanisms of diabetes development are various and complex. However, we need to underline the role of drug-induced weight gain. The duration of therapy is also important because longer therapy is usually associated with higher risk of development of diabetes.

Drug-induced diabetes is a significant clinical problem. The benefits of using the drug often outweigh the side effects associated with poor glycemic control. Currently, pharmacotherapy of drug-induced diabetes is similar to the standards of treatment for other types of diabetes. Changing therapy to the drug with lower metabolic risk should be considered as far as possible. Moreover, due to common presence of pesticides, heavy metals and endocrine-disrupting chemicals, inducing diabetes is also very problematic and constitutes an important area of new scientific researches.

Keywords:

type 3 diabetes, secondary diabetes, drug-induced diabetes, drug-induced hyperglycemia, insulin resistance


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Oleksa, P., Żuraw, D., Jasiński, K., Sobczyk, M., Porzak, M., Sodolska, A., & Haczkur-Pawłowska, K. (2024). Drugs and other chemical substances inducing diabetes – review of the literature. Prospects in Pharmaceutical Sciences, 22(2), 7–17. https://doi.org/10.56782/pps.183

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Editorial Team
Stefana Banacha 1
02-097 Warsaw, Poland
biuletynfarmacji@wum.edu.pl
Publisher:
Medical University of Warsaw
ul. Żwirki i Wigury 61
02-091 Warszawa

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