Small intestinal bacterial overgrowth – current, novel and possible future methods of treatment and diagnosis

Mateusz Sobczyk; Mikołaj Porzak; Daria Żuraw; Alicja Sodolska; Paulina Oleksa; Kacper Jasiński

doi:10.56782/pps.196

Published : 2024-06-17

Vol. 22 No. 2 (2024)

Small intestinal bacterial overgrowth – current, novel and possible future methods of treatment and diagnosis

Mateusz Sobczyk

Mikołaj Porzak

Daria Żuraw

Alicja Sodolska

Paulina Oleksa

Kacper Jasiński

DOI: https://doi.org/10.56782/pps.196

Abstract

Small intestinal bacterial overgrowth (SIBO) is a prevalent issue, frequently overlooked in clinical practice. Its prevalence is unknown because SIBO requires diagnostic testing, however, in most studies, SIBO has been detected anywhere from <2% to 22% of healthy controls. Breath tests, which detect the presence of hydrogen in exhaled air, are the most used diagnostic method. However, their low sensitivity and specificity indicate the need for research into new more accurate methods. The standard treatment is antibiotic therapy with rifaximin. After antibiotic therapy, there is a risk of recurrence and the emergence of multidrug-resistant bacterial strains. Recurrence ratio after antibiotic therapy have been documented in 12.6% of patients after 3 months, 27.5% after 6 months and 43.7% after 9 months. There are promising results from studies on the use of probiotics and herbal preparations in treatment, but these studies have been conducted on relatively small groups of patients. This indicates the need for multicentre randomised trials with large numbers of patients to develop effective methods for the diagnosis and treatment of SIBO.

Keywords:

SIBO, Irritable Bowel Syndrome, Rifaximin, probiotics, Intestinal Microbiota

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Sobczyk, M., Porzak, M., Żuraw, D., Sodolska, A., Oleksa, P., & Jasiński, K. (2024). Small intestinal bacterial overgrowth – current, novel and possible future methods of treatment and diagnosis. Prospects in Pharmaceutical Sciences, 22(2), 65–70. https://doi.org/10.56782/pps.196

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Mateusz Sobczyk

m.sobczyk1777@gmail.com
https://orcid.org/0000-0001-8690-2387

Affiliation:

a:1:{s:5:"en_US";s:83:"Wojewódzki Szpital Specjalistyczny im. Stefana Kardynała Wyszyńskiego w Lublinie";} Poland

Mikołaj Porzak

https://orcid.org/0000-0003-0548-1950

Affiliation:

Stefan Kardynał Wyszyński Province Specialist Hospital, al. Kraśnicka 100, 20-718 Lublin, Poland. Poland

Daria Żuraw

https://orcid.org/0000-0003-0815-4322

Affiliation:

Central Clinical Hospital, University Clinical Center of Warsaw Medical University, ul. Banacha 1A, 02-097 Warsaw. Poland

Alicja Sodolska

https://orcid.org/0009-0008-3689-7004

Affiliation:

Lubimed – Family Medicine Center Lublin, ul. Woronieckiego 11, 20-492 Lublin. Poland

Paulina Oleksa

https://orcid.org/0000-0002-3474-6156

Affiliation:

Independent Public Clinical Hospital No. 4 in Lublin, ul. Doktora Kazimierza Jaczewskiego 8, 20-954 Lublin Poland

Kacper Jasiński

https://orcid.org/0009-0003-3345-2337

Affiliation:

Stefan Kardynał Wyszyński Province Specialist Hospital, al. Kraśnicka 100, 20-718 Lublin, Poland. Poland