Role of calcitonin gene-related peptide (CGRP) receptor antagonist in acute and preventive treatment of migraine.

Michał Dacka; Mateusz Sobczyk; Paulina Dąbrowska; Kamila Giżewska; Michał Żuber

doi:10.56782/pps.206

Published : 2024-07-10

Vol. 22 No. 3 (2024)

Role of calcitonin gene-related peptide (CGRP) receptor antagonist in acute and preventive treatment of migraine

Michał Dacka

Mateusz Sobczyk

Paulina Dąbrowska

Kamila Giżewska

Michał Żuber

DOI: https://doi.org/10.56782/pps.206

Abstract

Migraine is the most common neurological disease in the world. It is characterized by recurrent attacks of severe headaches of a one-sided, throbbing nature, often accompanied by sensory and motor disturbances and generally associated with nausea and increased sensitivity to light and sound. Migraine treatment can be divided into emergency treatment and preventive treatment, which aims to reduce the overall frequency and severity of attacks. In the first case, nonsteroidal anti-inflammatory drugs (NSAIDs) can be used, but in some patients they do not have the desired effect. The gold standard in the fight against migraine pain are triptans (selective serotonin 5-HT1 receptor agonists), although they too are not effective in all patients. Current understanding suggests that calcitonin gene-related peptide (CGRP) plays a significant role in the pathophysiology of migraines. Evidence supporting this includes increased CGRP levels during migraine attacks, causing inflammation and activation of other pathophysiological processes responsible for pain. The hope for patients are CGRP receptor antagonists, which greatly expand therapeutic options.

Keywords:

CGRP, gepants, headache, rimegepant, ubrogepant, migraine

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Dacka, M., Sobczyk , M., Dąbrowska , P., Giżewska , K., & Żuber , M. (2024). Role of calcitonin gene-related peptide (CGRP) receptor antagonist in acute and preventive treatment of migraine. Prospects in Pharmaceutical Sciences, 22(3), 21–26. https://doi.org/10.56782/pps.206

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Michał Dacka

michal.dackaa@gmail.com
https://orcid.org/0009-0005-8783-6517

Affiliation:

a:1:{s:5:"en_US";s:81:"1 Military Clinical Hospital in Lublin, al. Racławickie 23,20-049 Lublin, Poland";} Poland

Mateusz Sobczyk

https://orcid.org/0000-0001-8690-2387

Affiliation:

Province Specialist Hospital named after Stefan Cardinal Wyszyński in Lublin Poland

Paulina Dąbrowska

https://orcid.org/0009-0004-6439-3357

Affiliation:

Province Specialist Hospital named after Stefan Cardinal Wyszyński in Lublin Poland

Kamila Giżewska

https://orcid.org/0000-0003-1682-180X

Affiliation:

1 Military Clinical Hospital in Lublin, al. Racławickie 23, 20-049 Lublin, Poland Poland

Michał Żuber

https://orcid.org/0009-0000-2538-8556

Affiliation:

4th Clinical University Hospital in Lublin, Poland: Lublin, PL Poland