Efficacy and Safety of Bempedoic Acid in Lipid Disorder Therapy: A Review of Clinical Trials

Paulina Dąbrowska; Michał Żuber; Michał Dacka

doi:10.56782/pps.208

Published : 2024-08-18

Vol. 22 No. 3 (2024)

Efficacy and safety of bempedoic acid in lipid disorder therapy: a review of clinical trials

Paulina Dąbrowska

Michał Żuber

Michał Dacka

DOI: https://doi.org/10.56782/pps.208

Abstract

LDL level is a key risk factor for atherosclerotic cardiovascular disease. Bempedoic acid is an innovative hypolipemic drug, particularly useful for patients with statin intolerance. The article focuses on analyzing the results of clinical trials on the mechanisms of action, efficacy and safety of bempedoic acid used both as monotherapy and in combination with other hypolipemic drugs. Scientific evidence based on the CLEAR: Tranquility, Harmony, Serenity, Wisdom, Outcomes study, among others, is presented. Its significant effects on lowering LDL-C, non-HDL-C, and hsCRP levels are highlighted, with important implications for the prevention and treatment of cardiovascular disease. It also outlines how bempedoic acid is included in current Polish guidelines for the treatment of lipid disorders. The paper also points to new areas of research, including potential applications of bempedoic acid in specific patient groups, such as pregnant women. In addition, the article addresses issues related to the long-term use and safety of bempedoic acid, particularly in the context of reducing cardiovascular risk and lowering blood lipid levels, which is crucial for patients with statin intolerance.

Keywords:

bempedoic acid, nonstatin therapy, statin intolerance, atherosclerotic cardiovascular disease, hypercholesterolemia

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Dąbrowska, P., Żuber, M., & Dacka, M. (2024). Efficacy and safety of bempedoic acid in lipid disorder therapy: a review of clinical trials. Prospects in Pharmaceutical Sciences, 22(3), 120–126. https://doi.org/10.56782/pps.208

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