Dapagliflozin - new solution in chronic kidney disease treatment

Maciej Bara; Jakub Starownik; Jakub Szydło; Patryk Gryszkiewicz; Jakub Nieznański

doi:10.56782/pps.195

Published : 2024-06-05

Vol. 22 No. 2 (2024)

Dapagliflozin - new solution in chronic kidney disease treatment

Maciej Bara

Jakub Starownik

Jakub Szydło

Patryk Gryszkiewicz

Jakub Nieznański

DOI: https://doi.org/10.56782/pps.195

Abstract

Despite being developed relatively recently, sodium-glucose cotransporter 2 (SGLT2) inhibitors have proven to be versatile pharmaceuticals useful in treatment of diabetes mellitus, heart failure and chronic kidney disease. Extensive and ongoing studies confirm more and more of their beneficial effects on metabolic, cardiovascular and renal health. Most of the conducted studies focused on patients suffering from diabetes mellitus type 2. Recent study, DAPA - CKD, published in the New England Journal of Medicine, confirmed the beneficial effect of dapagliflozin on chronic kidney disease of any etiology. This discovery has cemented flozins’ status as nephroprotective drugs and led to a new indication of use for dapagliflozin - chronic kidney disease. In Poland treatment of chronic kidney disease with dapagliflozin is reimbursed in patients with chronic kidney disease with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73m², albuminuria or proteinuria who were treated with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARB) for ≥4 weeks or with contraindications for ACEi/ARB therapy. Due to reimbursement, dapagliflozin therapy is financially available for a wide population of patients and, in light of recent discoveries, should be considered by clinicians.

Keywords:

dapagliflozin, chronic kidney disease, SGLT2i, nephrology

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Bara, M., Starownik, J., Szydło, J., Gryszkiewicz, P., & Nieznański, J. (2024). Dapagliflozin - new solution in chronic kidney disease treatment. Prospects in Pharmaceutical Sciences, 22(2), 59–64. https://doi.org/10.56782/pps.195

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Dapagliflozin - new solution in chronic kidney disease treatment

Maciej Bara

Jakub Starownik

Jakub Szydło

Patryk Gryszkiewicz

Jakub Nieznański

Abstract

Keywords:

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