Mirikizumab – a new option in treatment of inflammatory bowel diseases

Jakub Olszewski; Katarzyna Kozon; Magdalena Sitnik; Katarzyna Herjan; Karolina Mikołap; Bartłomiej Gastoł; Maciej Bara; Piotr Armański; Marcin Sawczuk

doi:10.56782/pps.262

Published : 2024-09-23

Vol. 22 No. 3 (2024)

Mirikizumab – a new option in the treatment of inflammatory bowel diseases

Jakub Olszewski

Katarzyna Kozon

Magdalena Sitnik

Katarzyna Herjan

Karolina Mikołap

Bartłomiej Gastoł

Maciej Bara

Piotr Armański

Marcin Sawczuk

DOI: https://doi.org/10.56782/pps.262

Abstract

ABSTRACT

Mirikizumab is a humanized monoclonal antibody targeting the p19 subunit of interleukin IL-23. Over the past few years, it has been the subject of clinical trials as a potential new treatment for inflammatory bowel diseases, including ulcerative colitis and Crohn's disease. Additionally, mirikizumab has been investigated in clinical trials as a potential treatment for plaque psoriasis. The results of clinical trials for mirikizumab in treating ulcerative colitis led to its approval in the European Union, the United States, Canada, and Japan for treating adult patients with moderately to severely active ulcerative colitis. Despite promising clinical trial results, mirikizumab has not yet been approved for the treatment of Crohn's disease. This review focuses on summarizing the findings from clinical trials of mirikizumab in the treatment of inflammatory bowel diseases. Information is sourced from scientific papers available on PubMed, by searching for "mirikizumab" and “IL-23” and published to March 2024, as well as from published results of clinical trials concerning mirikizumab.

Keywords:

mirikizumab, IL-23, ulcerative colitis

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Olszewski, J., Kozon, K., Sitnik, M., Herjan, K., Mikołap, K., Gastoł, B., … Sawczuk, M. (2024). Mirikizumab – a new option in the treatment of inflammatory bowel diseases. Prospects in Pharmaceutical Sciences, 22(3), 178–185. https://doi.org/10.56782/pps.262

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Jakub Olszewski

olszewskij3@gmail.com

Katarzyna Kozon

Affiliation:

Prof. W. Orłowski Memorial Hospital, 00-401 Warsaw, Poland Poland

Magdalena Sitnik

Affiliation:

Masovian Brodnowski Hospital, 03-242 Warsaw, Poland Poland

Katarzyna Herjan

Affiliation:

Prof. W. Orłowski Memorial Hospital, 00-401 Warsaw, Poland Poland

Karolina Mikołap

Affiliation:

Wolski Hospital in Warsaw, 01-211 Warsaw, Poland Poland

Bartłomiej Gastoł

Affiliation:

Masovian Specialist Hospital in Ostrołęka, 07-410 Ostrołęka, Poland Poland

Maciej Bara

Affiliation:

Infant Jesus Clinical Hospital, Medical University of Warsaw, 02-005 Warsaw, Poland Poland

Piotr Armański

Affiliation:

District Hospital in Sochaczew, 96-500 Sochaczew, Poland Poland

Marcin Sawczuk

Affiliation:

Medical University of Gdansk Clinical Center, 80-952 Gdańsk, Poland Poland