Inclisiran - a new solution for the prevention and treatment of atherosclerotic cardiovascular disease
DOI:
https://doi.org/10.56782/pps.241Keywords:
inclisiran, atherosclerotic cardiovascular disease, PCSK9, cardiologyAbstract
A major cause of morbidity and mortality worldwide is atherosclerotic cardiovascular disease (ASCVD), the prevalence of which has been increasing significantly over the past few decades. Elevated concentration of low-density lipoprotein cholesterol (LDL-C) is one of the most important modifiable risk factors associated with the development of ASCVD. Lowering LDL-C concentration is an important intervention in the primary and secondary prevention of cardiovascular events in patients with ASCVD or at risk for ASCVD. Inclisiran is a new formulation containing small interfering RNA (siRNA) that inhibits the production of PCSK9 protein in the liver. Decreased production of PCSK 9 leads to lower LDL-C concentrations by increasing the formation of receptors that are responsible for LDL-C uptake, resulting in increased LDL-C uptake and consequently lower blood LDL-C concentrations. This narrative review discusses the effects of inclisiran on LDL-C concentrations, with the aim of evaluating the drug's efficacy, safety and tolerable doses. Studies confirm that inclisiran is an effective and safe LDL-C-lowering drug that reduces the risk of ASCVD. Inclisiran is another treatment in the standards for LDL-C-lowering therapy in patients with ASCVD or high risk of ASCVD.
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Copyright (c) 2024 Paulina Lis, Anna Lis, Wojciech Kaźmierski, Jakub Jurek, Mateusz Ziomek, Kinga Kocur, Anna Ziobro, Katarzyna Camlet
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