INCLISIRAN - A NEW SOLUTION FOR THE PREVENTION AND TREATMENT OF ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Paulina Lis; Anna Lis; Wojciech Kaźmierski; Jakub Jurek; Mateusz Ziomek; Kinga Kocur; Anna Ziobro; Katarzyna Camlet

doi:10.56782/pps.241

Published : 2024-08-27

Vol. 22 No. 3 (2024)

Inclisiran - a new solution for the prevention and treatment of atherosclerotic cardiovascular disease

Paulina Lis

Anna Lis

Wojciech Kaźmierski

Jakub Jurek

Mateusz Ziomek

Kinga Kocur

Anna Ziobro

Katarzyna Camlet

DOI: https://doi.org/10.56782/pps.241

Abstract

A major cause of morbidity and mortality worldwide is atherosclerotic cardiovascular disease (ASCVD), the prevalence of which has been increasing significantly over the past few decades. Elevated concentration of low-density lipoprotein cholesterol (LDL-C) is one of the most important modifiable risk factors associated with the development of ASCVD. Lowering LDL-C concentration is an important intervention in the primary and secondary prevention of cardiovascular events in patients with ASCVD or at risk for ASCVD. Inclisiran is a new formulation containing small interfering RNA (siRNA) that inhibits the production of PCSK9 protein in the liver. Decreased production of PCSK 9 leads to lower LDL-C concentrations by increasing the formation of receptors that are responsible for LDL-C uptake, resulting in increased LDL-C uptake and consequently lower blood LDL-C concentrations. This narrative review discusses the effects of inclisiran on LDL-C concentrations, with the aim of evaluating the drug's efficacy, safety and tolerable doses. Studies confirm that inclisiran is an effective and safe LDL-C-lowering drug that reduces the risk of ASCVD. Inclisiran is another treatment in the standards for LDL-C-lowering therapy in patients with ASCVD or high risk of ASCVD.

Keywords:

inclisiran, atherosclerotic cardiovascular disease, PCSK9, cardiology

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Lis, P., Lis, A., Kaźmierski, W., Jurek, J., Ziomek, M., Kocur, K., Ziobro, A., & Camlet, K. (2024). Inclisiran - a new solution for the prevention and treatment of atherosclerotic cardiovascular disease. Prospects in Pharmaceutical Sciences, 22(3), 136–141. https://doi.org/10.56782/pps.241

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Paulina Lis

lispaulinab@gmail.com
https://orcid.org/0009-0004-0652-4822

Affiliation:

a:1:{s:5:"en_US";s:137:"Górnośląskie Centrum Medyczne im. prof. Leszka Gieca Śląskiego Uniwersytetu Medycznego w Katowicach, Ziołowa 45/47, 40-635 Katowice";} Poland

Anna Lis

Affiliation:

Górnośląskie Centrum Medyczne im. prof. Leszka Gieca Śląskiego Uniwersytetu Medycznego w Katowicach, Ziołowa 45/47, 40-635 Katowice Poland

Wojciech Kaźmierski

Affiliation:

Wydział Lekarski i Nauk o Zdrowiu, Akademia im. Andrzeja Frycza Modrzewskiego w Krakowie, Gustawa Herlinga-Grudzińskiego 1, 30-705 Kraków Poland

Jakub Jurek

Affiliation:

Wydział Lekarski i Nauk o Zdrowiu, Akademia im. Andrzeja Frycza Modrzewskiego w Krakowie, Gustawa Herlinga-Grudzińskiego 1, 30-705 Kraków Poland

Mateusz Ziomek

Affiliation:

Wojskowy Instytut Medyczny - Państwowy Instytut Badawczy, Szaserów 128, 04-141 Warszawa Poland

Kinga Kocur

Affiliation:

Szpital Powiatowy im. Św. Maksymiliana w Oświęcimiu, Wysokie Brzegi 4, 32-600 Oświęcim Poland

Anna Ziobro

Affiliation:

Szpital Powiatowy im. dra Tytusa Chałubińskiego w Zakopanem, Kamieniec 10, 34-500 Zakopane Poland

Katarzyna Camlet

Affiliation:

Szpital Powiatowy im. dra Tytusa Chałubińskiego w Zakopanem, Kamieniec 10, 34-500 Zakopane Poland