Sodium bicarbonate - known medication, new prospects?

Anna Lis; Paulina Lis; Wojciech Kaźmierski; Kinga Kocur; Katarzyna Camlet; Jakub Jurek; Mateusz Ziomek; Anna Ziobro

doi:10.56782/pps.249

Published : 2024-09-24

Vol. 22 No. 3 (2024)

Sodium bicarbonate - known medication, new prospects?

Anna Lis

Paulina Lis

Wojciech Kaźmierski

Kinga Kocur

Katarzyna Camlet

Jakub Jurek

Mateusz Ziomek

Anna Ziobro

DOI: https://doi.org/10.56782/pps.249

Abstract

Critical conditions frequently involve disturbances in blood gas analysis and electrolyte imbalances. Sodium bicarbonate has seen expanded medical use in recent years. The European Resuscitation Council (ERC) Guidelines endorse sodium bicarbonate for hyperkalemia, malignant hyperthermia, and specific drug intoxications. Its potential roles in treating intracranial hypertension and symptomatic hyponatremia are also being explored. However, its application in emergency departments (ED) remains inconsistent, particularly in profound metabolic acidosis cases. We conducted a review of sodium bicarbonate’s therapeutic uses. The evolving understanding of sodium bicarbonate's role in emergency medicine and intensive care highlights both its potential applications and associated risks. While not universally beneficial, especially in lactic acidosis, it may aid specific patient subgroups, such as those with acute kidney injury. Its use in hyperkalemia, intracranial hypertension and diabetic ketoacidosis (DKA) also presents mixed results, with potential benefits in particular contexts. Further large-scale, randomized controlled trials are needed to develop precise guidelines, ensuring its safe and effective use tailored to individual patient needs.

Keywords:

bicarbonate, lactic acidosis, hyperkalemia, diabetic ketoacidosis, intracranial hypertension

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Lis, A., Lis, P., Kaźmierski, W., Kocur, K., Camlet, K., Jurek, J., … Ziobro, A. (2024). Sodium bicarbonate - known medication, new prospects?. Prospects in Pharmaceutical Sciences, 22(3), 198–203. https://doi.org/10.56782/pps.249

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Anna Lis

lis.anna9898@gmail.com

Affiliation:

a:1:{s:5:"en_US";s:132:"Leszek Giec Upper- Silesian Medical Centre of the Medical University of Silesia in Katowice, Ziołowa 45/47, 40-635 Katowice, Poland";} Poland

Paulina Lis

lispaulinab@gmail.com

Affiliation:

Leszek Giec Upper- Silesian Medical Centre of the Medical University of Silesia in Katowice, Ziołowa 45/47, 40-635 Katowice, Poland Poland

Wojciech Kaźmierski

wkazmierski97@gmail.com

Affiliation:

Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland Poland

Kinga Kocur

kingakocur98@wp.pl

Affiliation:

District Hospital st.Maximilian in Oświęcim, Wysokie Brzegi 4, 32-600 Oświęcim, Poland Poland

Katarzyna Camlet

katarzyna.camlet@gmail.com

Affiliation:

District Hospital in Zakopane, Kamieniec 10, 34-500 Zakopane, Poland Poland

Jakub Jurek

kubajurek1999@gmail.com

Affiliation:

Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland Poland

Mateusz Ziomek

mateusz.ziomek98@gmail.com

Affiliation:

Military Institute of Medicine - National Research Institute, Szaserów 128, 04-141 Warsaw, Poland Poland

Anna Ziobro

aannaziobro@gmail.com

Affiliation:

District Hospital in Zakopane, Kamieniec 10, 34-500 Zakopane, Poland Poland

Sodium bicarbonate - known medication, new prospects?

Anna Lis

Paulina Lis

Wojciech Kaźmierski

Kinga Kocur

Katarzyna Camlet

Jakub Jurek

Mateusz Ziomek

Anna Ziobro

Abstract

Keywords:

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