NADCIŚNIENIE PŁUCNE — PATOFIZJOLOGIA I LEKI WYKORZYSTYWANE W TERAPII

Iwona Lewandowska Lewandowska; Monika Zielińska-Pisklak; Łukasz Szeleszczuk; Dariusz Maciej Pisklak; Marcin Sobczak

doi:10.56782/pps.17

Published : 2020-08-07

Vol. 18 No. 2 (2020)

PULMONARY HYPERTENSION — PATHOPHYSIOLOGY AND DRUGS USED IN THERAPY

Iwona Lewandowska Lewandowska

Monika Zielińska-Pisklak

Łukasz Szeleszczuk

Dariusz Maciej Pisklak

Marcin Sobczak

DOI: https://doi.org/10.56782/pps.17

Abstract

Pulmonary hypertension (PH) is a relatively rare disease with a severe course characterized by the presence of elevated blood pressure in the pulmonary circulation. Non-specific symptoms and the lack of a simple diagnostic method contribute to the late detection of the disease, which significantly worsens the prognosis and increases the cost and invasiveness of treatment. In this article a classification of PH due to its etiology is presented and the individual types of PH with regard to their pathophysiology are characterized. Moreover, PH diagnostics and drug types used in therapy (e.g. endothelin receptor antagonists, prostanoids, phosphodiesterase type 5 inhibitors) are described.

Keywords:

pulmonary hypertension, phosphodiesterase type 5 inhibitors, endothelin receptor antagonists, prostanoids

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Lewandowska, I. L., Zielińska-Pisklak, M., Szeleszczuk, Łukasz, Maciej Pisklak, D., & Sobczak, M. (2020). PULMONARY HYPERTENSION — PATHOPHYSIOLOGY AND DRUGS USED IN THERAPY. Prospects in Pharmaceutical Sciences, 18(2), 10–18. https://doi.org/10.56782/pps.17

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Iwona Lewandowska Lewandowska

Affiliation:

Studenckie Koło Naukowe „Spectrum” przy Katedrze Chemii Analitycznej i Biomateriałów, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Warszawski Uniwersytet Medyczny, ul. Banacha 1, 02-097 Warszawa; Studenckie Koło Naukowe „Free Radicals” przy Zakładzie Chemii Fizycznej, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Warszawski Uniwersytet Medyczny, ul. Banacha 1, 02-097 Warszawa Poland

Monika Zielińska-Pisklak

mpisklak@wum.edu.pl

Affiliation:

Zakład Chemii Biomateriałów, Katedra Chemii Analitycznej i Biomateriałów, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Warszawski Uniwersytet Medyczny, ul. Banacha 1, 02-097 Warszawa Poland

Łukasz Szeleszczuk

Affiliation:

Zakład Chemii Fizycznej, Katedra Farmacji Fizycznej i Bioanalizy, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Warszawski Uniwersytet Medyczny, ul. Banacha 1, 02-097 Warszawa Poland

Dariusz Maciej Pisklak

Affiliation:

Zakład Chemii Fizycznej, Katedra Farmacji Fizycznej i Bioanalizy, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej, Warszawski Uniwersytet Medyczny, ul. Banacha 1, 02-097 Warszawa Poland

Marcin Sobczak

Affiliation: