CYKLODEKSTRYNY — ZASTOSOWANIE W PRZEMYŚLE FARMACEUTYCZNYM
DOI:
https://doi.org/10.56782/pps.16Keywords:
kompleksy supramolekularne substancja lecznicza-cyklodekstryny, modyfikowane uwalnianieAbstract
Cyklodekstryny (CDs) należą do grupy cyklicznych oligosacharydów złożonych z kilku podjednostek α-glukopiranozy. Zainteresowanie przemysłu farmaceutycznego CDs wynika z jednej strony z łatwości ich pozyskiwania i modyfikacji, z drugiej zaś ze zdolności do tworzenia przez nie kompleksów supramolekularnych z substancjami leczniczymi. Wspomniane właściwości sprawiły, że CDs są wykorzystywane do otrzymywania postaci leków o przedłużonym uwalnianiu. W niniejszym artykule scharakteryzowano budowę CDs i ich właściwości. Ponadto omówiono sposoby ich modyfikacji, a także zastosowania CDs naturalnych i modyfikowanych w przemyśle farmaceutycznym. Przedstawiono również aspekt bezpieczeństwa ich stosowania i metabolizm.
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