SCHIFF BASE COPPER (II) COMPLEXES - NOVEL COMPOUNDS WITH ANTIMICROBIAL ACTIVITY
DOI:
https://doi.org/10.56782/pps.81Keywords:
salicylaldehyde, coumarin, Schiff base, copper(II) complex, antimicrobial activityAbstract
Schiff bases are prepared via condensation of primary amines and aldehydes or ketones. The products are stable and exhibit antimicrobial, antiproliferative, as well as anti-inflammatory activity. Using them as ligands in the preparation of copper (II) complexes results in an increase of their biological activity. This paper reviews the latest literature reports concerning the antimicrobial activity of Schiff bases: derivatives of salicylaldehyde and 7-hydroxycoumarin, 8-substituted with a formyl or an acetyl group. We also describe the biological activity of their copper(II) complexes.
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Przybylski P., Buczyński A., Brzeziński B., Schroeder G., Aktywność biologiczna zasad Schiffa i innych aza-pochodnych fenoli. Schroeder W.G. (red.): Materiały supramolekularne. Poznań: Betagraf P.U.H., 2008, 89-133.
Joseyphus R. S. and Nair M. S., Antibacterial and Antifungal Studies on Some Schiff Base Complexes of Zinc(II), Mycobiology, 2008, 36 (2), 93-98. DOI: https://doi.org/10.4489/MYCO.2008.36.2.093
Rani A., Kumar M., Khare R. and Tuli H. S., Schiff bases as an antimicrobial agent: A review. Journal of Biological and Chemical Sciences (JBCS), 2015, 2(1) 62-91.
https://dailymed.nlm.nih.gov/ dailymed/drugInfo, 21.08.2017.
https://www.accessdata.fda.gov /scripts/cder/daf/index.cfm?event=overview. process&ApplNo=019456. 21.08.2017.
da Silva M. C., da Silva D. L., Modolo L. V., Alves R. B., de Resende M. A., Martins C. V. B., de Fatima A., Schiff bases: A short review of their antimicrobial activities, Journal of Advanced Research, 2011, (2), 1–8. DOI: https://doi.org/10.1016/j.jare.2010.05.004
de Souza A. O., Galetti F. C. S., and Silva C. L., Bicalho B., Parma M. M., Fonseca S. F. and Marsaioli A. J., Trindade A. C. L. B., Rossimíriam P., Gil F, Bezerra F. S., Andrade-Neto M. and de Oliveira M. C. F., Antimycobacterial And Cytotoxicity Activity Of Synthetic And Natural Compounds, Quim. Nova, 2007, 30 (7), 1563-1566. DOI: https://doi.org/10.1590/S0100-40422007000700012
Shi L, Ge H-M., Tan S-H., Li H-Qi., Song Y-C., Zhu H-L., Tan R-Xi., Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde, European Journal of Medicinal Chemistry 2007, 42(4), 558-564. DOI: https://doi.org/10.1016/j.ejmech.2006.11.010
Tantaru G., Popescu M-C., Bilda V., Poiata A., Lisa G. and Vasile C., Spectroscopic, thermal and antimicrobial properties of the copper(II) complex of Schiff base derived from 2-(salicylidene) aminopyridine, Appl. Organometal. Chem. 2012, 26, 356–361. DOI: https://doi.org/10.1002/aoc.2872
Hejchman E., Tomczyk M., Związki kompleksowe miedzi(II) jako potencjalne leki przeciwnowotworowe. Farmacja Polska. 2015, 71(12), 750-757.
Joshi K. R., Rojivadiya A. J., and Pandya J. H.. Synthesis and Spectroscopic and Antimicrobial Studies of Schiff Base Metal Complexes Derived from 2-Hydroxy-3-methoxy-5-nitrobenzaldehyde. Hindawi Publishing Corporation, International Journal of Inorganic Chemistry. 2014, Article ID 817412, 1-8, http://dx.doi.org/10.1155/ 2014/817412, 21.08.2017. DOI: https://doi.org/10.1155/2014/817412
Thakur A., Singla R., Jaitak V. Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies. Eur. J. Med. Chem., 2015, 101, 476-495. DOI: https://doi.org/10.1016/j.ejmech.2015.07.010
Singh D., Pathak D. P. and Anjali, Coumarins: An Overview Of Medicinal Chemistry. Potential For New Drug Molecules. International Journal of Pharmaceutical Sciences and Research. 2016, 7(2), 482-504.
Ostrowska K., Hejchman E., Grzeszczuk D., Kruk N.. Leki kumarynowe. Farmacja Polska. 2013, 69(5), 303-310.
Creaven B. S,, Devereux M., Karcz D., Kellett A., McCann M., Noble A., Walsh M., Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity. Journal of Inorganic Biochemistry 2009, 103, 1196-1203. DOI: https://doi.org/10.1016/j.jinorgbio.2009.05.017
Bagihalli G. B., Avaji P. G, Patil S. A., Badami P. S., Synthesis, spectral characterization, in vitro antibacterial, antifungal and cytotoxic activities of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases, Eur. J. Med. Chem, 2008, 43, 2639-2649. DOI: https://doi.org/10.1016/j.ejmech.2008.02.013
Bagihalli G. .B., Badami P. S. & Patil S. A., Synthesis, spectral characterization and in vitro biological studies of Co(II), Ni(II) and Cu(II) complexes with 1,2,4-triazole Schiff bases Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24(2), 381-394. DOI: https://doi.org/10.1080/14756360802187901
Patil S. A., Unki S. N., Badami P. S., Synthesis, characterization, biological and thermal behavior of Co(II), Ni(II) and Cu(II) complexes with Schiff bases having coumarin moieties. J. Therm. Anal. Calorim., 2013, 111, 1281-1289. DOI: https://doi.org/10.1007/s10973-012-2293-7
Prabhakara C. T., Patil S. A., Toragalmath S. S., Kinnal S. M., Badami P. S., Synthesis, characterization and biological approach of metal chelates of some first row transition metal ions with halogenated bidentate coumarin Schiff bases containing N and O donor atoms, Journal of Photochemistry & Photobiology, B: Biology , 2016, 157, 1-14. DOI: https://doi.org/10.1016/j.jphotobiol.2016.02.004
Phaniband M. A., Dhumwad S. D., Pattan S. R., Synthesis, characterization, antimicrobial, and DNA cleavage studies of metal complexes of coumarin Schiff bases, Med. Chem. Res., 2011, 20, 493-502. DOI: https://doi.org/10.1007/s00044-010-9343-0
Patil S. A., Unki S. N., Badami P. S., In vitro antibacterial, antifungal, and DNA cleavage studies of coumarin Schiff bases and their metal complexes: synthesis and spectral characterization. Med. Chem. Res., 2012, 21, 4017-4027. DOI: https://doi.org/10.1007/s00044-011-9932-6
Prabhakara C. T., Patil S. A., Kulkarni A. D., Naik V. H., Manjunatha M., Kinnal S. M., Badami P. S., Synthesis, spectral, thermal, fluorescence, antimicrobial, anthelmintic and DNA cleavage studies of mononuclear metal chelates of bi-dentate 2H-chromene-2-one Schiff base. Journal of Photochemistry and Photobiology B: Biology 2015, 148, 322-332. DOI: https://doi.org/10.1016/j.jphotobiol.2015.03.033
Sawant S. S., Pavar V. ,Janrao S., Yamgar R. S. and Nivid Y., Synthesis And Characterization Of Transition Metal Complexes Of Novel Schiff Base 8-[(Z)-[(3-N-Methylamino)Propyl]Imino)Methyl]-7-Hydroxy-4-Methyl-2H-Chromen-2-One] [NMAPIMHC] And Their Biological Activities, International Journal of Research in Pharmacy and Chemistry, 2013, 3(3), 636-644, www.ijrpc.com.
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