Cotoneaster horizontalis Decne. (Rosaceae) - medicinal or just ornamental species?
DOI:
https://doi.org/10.56782/pps.187Keywords:
Cotoneaster, Rosaceae, medicinal plants, ornamental plantsAbstract
The genus Cotoneaster Medikus (Rosaceae) includes many species traditionally used in Asian medicine to treat, among others, cardiovascular diseases, cuts and wounds, diabetes, hemorrhoids, abdominal pain, eye diseases and fever. A representative of this group of plants is Cotoneaster horizontalis Decne., whose health-promoting and healing effects have been confirmed in many scientific studies. To date, compounds such as phenolic acids, flavonoids, cyanogenic glycosides, essential oils, fatty acids, triterpenes, sterols and vitamins have been identified or isolated in the leaves, fruits, flowers and twigs of C. horizontalis. Many of them are responsible for pharmacological properties, including antioxidant, hepatoprotective, antidiabetic, antibacterial and antifungal properties. Despite numerous studies on the phytochemistry, pharmacology and toxicology of extracts from individual parts of C. horizontalis, the available literature lacks a review paper summarizing the achievements of current reports on the effects and safety of use of this species. This work is a collection of information available in the scientific literature regarding the morphology, chemical composition, biological activity and cytotoxicity of extracts and compounds obtained from C. horizontalis. This work, by indicating further research perspectives, constitutes an important reference base for subsequent research on various medical applications of both extracts and pure isolates of C. horizontalis.
Downloads
References
Ribeiro, A.S.; Estanqueiro, M.; Oliveira, M.B.; Sousa Lobo, J.M. Main benefits and applicability of plant extracts in skin care products. Cosmetics 2015, 2, 48–65. doi:10.3390/cosmetics2020048. DOI: https://doi.org/10.3390/cosmetics2020048
https://www.worldfloraonline.org/taxon/wfo-4000009472 (accessed on 05.02.2024).
Chang, C.-S.; Jeon, J.I. Leaf flavonoids in Cotoneaster wilsonii (Rosaceae) from the island Ulleung-do, Korea. Biochem. Syst. Ecol. 2003, 31, 171–179. doi:10.1016/S0305-1978(02)00064-9. DOI: https://doi.org/10.1016/S0305-1978(02)00064-9
Mahmutović-Dizdarević, I.; Dizdar, M.; Čulum, D.; Vidic, D.; Dahija, S.; Jerković-Mujkić, A.; Bešta-Gajević, R. Phenolic composition, antioxidant and antimicrobial activity of Cotoneaster Medik. species from Bosnia and Herzegovina. Bull. Chem. Technol. Bosnia Herzeg. 2020, 54, 1–6. doi: 10.35666/ghtbh.2020.54.01.
Khan, S.; Wang, Z.;Wang, R.; Zhang, L. Horizontoates A–C: New cholinesterase inhibitors from Cotoneaster horizontalis. Phytochem. Lett. 2014, 10, 204–208. doi: 10.1016/j.phytol.2014.09.007. DOI: https://doi.org/10.1016/j.phytol.2014.09.007
Holzer, V.M.D.; Lower-Nedza, A.D.; Nandintsetseg, M.; Batkhuu, J.; Brantner, A.H. Antioxidant constituents of Cotoneaster melanocarpus Lodd. Antioxidants 2013, 2, 265–272. doi: 10.3390/antiox2040265. DOI: https://doi.org/10.3390/antiox2040265
Les, F.; López, V.; Caprioli, G.; Iannarelli, R.; Fiorini, D.; Innocenti, M.; Bellumori, M.; Maggi, F. Chemical constituents, radical scavenging activity and enzyme inhibitory capacity of fruits from Cotoneaster pannosus Franch. Food Funct. 2017, 8, 1775–1784. doi: 10.1039/C7FO00330G. DOI: https://doi.org/10.1039/C7FO00330G
Zengin, G.; Uysal, A.; Gunes, E.; Aktumsek, A. Survey of phytochemical composition and biological effects of three extracts from a wild plant (Cotoneaster nummularia Fisch. et Mey.): A potential source for functional food ingredients and drug formulations. PLoS ONE. 2014, 9(11), doi: 10.1371/journal.pone.0113527. DOI: https://doi.org/10.1371/journal.pone.0113527
Zengin, G.; Ferrante, C.; Menghini, L.; Orlando, G.; Brunetti, L.; Recinella, L.; Chiavaroli, A.; Leone, S.; Ronci, M.; Aumeeruddy, M.Z.; et al. Protective effects of Cotoneaster integerrimus on in vitro and ex-vivo models of H2O2-induced lactate dehydrogenase activity in HCT116 cell and on lipopolysaccharide-induced inflammation in rat colon. J. Food Biochem. 2019, 43, doi: 10.1111/jfbc.12766. DOI: https://doi.org/10.1111/jfbc.12766
Esmaeili, S.; Ghiaee, A.; Naghibi, F.; Mosaddegh, M. Antiplasmodial activity and cytotoxicity of plants used in traditional medicine of Iran for the treatment of fever. Iran J. Pharm. Res. 2015, 14, 103–107.
Kicel, A.; Kołodziejczyk-Czepas, J.; Owczarek, A.; Marchelak, A.; Sopinska, M.; Ciszewski, P.; Nowak, P.; Olszewska, M.A. Polyphenol-rich extracts from Cotoneaster leaves inhibit pro-inflammatory enzymes and protect human plasma components against oxidative stress in vitro. Molecules 2018, 23, Art. No: 2472. doi: 10.3390/molecules23102472. DOI: https://doi.org/10.3390/molecules23102472
Swati, S.; Manjula, R.R.; Sowjanya, K.; Vennela, Y.; Tanuja, K. A phyto pharmacological review on Cotoneaster microphyllus species. J. Pharm. Sci. Res. 2018, 10, 2166–2168.
Khan, S.; Yasmeen, S.; Afza, N.; Malik, A.; Iqbal, L.; Lateef, M. Cotonoates A and B, new aromatic esters from Cotoneaster racemiflora. Z. Naturforsch. B. 2008, 63, 1219–1222. doi: 10.1515/znb-2008-1013. DOI: https://doi.org/10.1515/znb-2008-1013
https://powo.science.kew.org (accessed on 10.01.2024).
Dickoré, W.B.; Kasperek, G. Species of Cotoneaster (Rosaceae, Maloideae) indigenous to, naturalising or commonly cultivated in Central Europe. Willdenowia 2010, 40, 13-45. doi:10.3372/wi.40.40102. DOI: https://doi.org/10.3372/wi.40.40102
Piqueray, J.; Mahy, G.; Vanderhoeven, S. Naturalization and impact of a horticultural species, Cotoneaster horizontalis (Rosaceae) in biodiversity hotspots in Belgium. Belgian J. Bot. 2008, 141, 113-124. doi:10.2307/20794659.
Jerzak, E. Irgi uprawiane w Polsce, Wyd. 1; Officina Botanica, Kraków, Polska, 2007; p. 31.
Bailey, L.H.; Bailey, E.Z. Hortus Third: A Concise Dictionary of Plants Cultivated in the United States and Canada, Revised by Staff of the L. H. Bailey Hortium; The Macmillan Publishing Company, New York, 1976.
Kicel, A. An overview of the genus Cotoneaster (Rosaceae): phytochemistry, biological activity, and toxicology. Antioxidants 2020, 9, Art. No: 1002. doi: 10.3390/antiox9101002. DOI: https://doi.org/10.3390/antiox9101002
Popoviciu, D.R.; Negreanu-Pirjol, T.; Motelica, L.; Pirjol, B.S.N. Carotenoids, flavonoids, total phenolic compounds and antioxidant activity of two creeping Cotoneaster species fruits extracts. Rev. Chim. 2020, 71, 136-142 doi: 10.37358/RC.20.3.7981. DOI: https://doi.org/10.37358/RC.20.3.7981
Sokkar, N.; El-Gindi, O.; Sayed, S.; Mohamed, S.; Ali, Z.; Alfishawy, I. Antioxidant, anticancer and hepatoprotective activities of Cotoneaster horizontalis Decne extract as well as α-tocopherol and amygdalin production from in vitro culture. Acta Physiol. Plant. 2013, 35, 2421–2428. doi: 10.1007/s11738-013-1276-z. DOI: https://doi.org/10.1007/s11738-013-1276-z
Mohamed, S.A.; Sokkar, N M.; El-Gindi, O.; Ali, Z.Y.; Alfishawy, I.A. Phytoconstituents investigation, anti-diabetic and anti-dyslipidemic activities of Cotoneaster horizontalis Decne cultivated in Egypt. Life Sci. J. 2012, 9, 394-403.
Sytar, O.; Hemmerich, I.; Zivcak, M.; Rauh, C.; Brestic, M. Comparative analysis of bioactive phenolic compounds composition from 26 medicinal plants. Saudi J. Biol. Sci. 2018, 25, 631-641. doi: 10.1016/j.sjbs.2016.01.036. DOI: https://doi.org/10.1016/j.sjbs.2016.01.036
Kicel, A.; Michel, P.; Owczarek, A.; Marchelak, A.; Zyzelewicz, D.; Budryn, G.; Oracz, J.; Olszewska, M.A. Phenolic profile and antioxidant potential of leaves from selected Cotoneaster Medik. species. Molecules 2016, 21, 688. doi: 10.3390/molecules21060688. DOI: https://doi.org/10.3390/molecules21060688
Kicel, A.; Kolodziejczyk-Czepas, J.; Owczarek, A.; Rutkowska, M.; Wajs-Bonikowska, A.; Granica, S.; Nowak, P.; Olszewska, M.A. Multifunctional phytocompounds in Cotoneaster fruits: phytochemical profiling, cellular safety, anti-Inflammatory and antioxidant effects in chemical and human plasma models in vitro. Oxid. Med. Cell Longev. 2018, 24, 3482521. doi: 10.1155/2018/3482521. DOI: https://doi.org/10.1155/2018/3482521
Koss-Mikołajczyk, I.; Baranowska, M.; Namieśnik, J.; Bartoszek-Pączkowska, A. Metody oznaczania właściwości przeciwutleniających fitozwiązków w systemach komórkowych z wykorzystaniem zjawiska fluorescencji/luminescencji. Postępy Hig. Med. Dosw. 2017, 71, 602-616; doi: 10.5604/01.3001.0010.3841. DOI: https://doi.org/10.5604/01.3001.0010.3841
Krzemińska, B.; Dybowski, M.P.; Klimek, K.; Typek, R.; Miazga-Karska, M.; Dos Santos Szewczyk, K. The anti-acne potential and chemical composition of two cultivated Cotoneaster species. Cells 2022, 11, Art. No: 367. doi.org/10.3390/cells11030367. DOI: https://doi.org/10.3390/cells11030367
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Barbara Krzemińska, Gabriela Szewczyk

This work is licensed under a Creative Commons Attribution 4.0 International License.
For all articles published in Prospects in Pharmaceutical Sciences copyright is retained by the authors. The journal publishes articles in the Open Access policy, within the CC BY 4.0 licence.
This is a human-readable summary of (and not a substitute for) the license. Disclaimer.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.