Active compounds in plants of the genus Alchemilla with proven skin care and therapeutic properties in the treatment of skin diseases
DOI:
https://doi.org/10.56782/pps.279Keywords:
Alchemilla, Rosaceae, cosmetics, natural products, skin diseasesAbstract
The genus Alchemilla (Rosaceae) includes many species traditionally used in Asian medicine and modern cosmetology in order to treat numerous skin dysfunctions such as acne, psoriatic, atopic dermatitis, wounds, wrinkles and hyperpigmentation. These plants contain compounds with documented dermatological activities, e.g.: tannins, flavonoids (catechins, flavones, flavonols, flavanones, isoflavones), proanthocyanidins (condensed tannins), phenolic acids, aldehydes, alcohols, triterpenes and stilbenes, among others. Compounds present in Alchemilla species exhibit anti-acne, anti-aging, collagen production-enhancing, anti-inflammatory, antimelanogenic, antioxidant, photoprotective, emollient, hair growth-stimulating, moisturizing, immunomodulatory, anticancerogenic and epidermal regeneration activities. The present work, indicating further research perspectives, provides an important reference base for further studies on the various cosmetic applications of both extracts and pure isolates obtained from the Alchemilla genus.
Downloads
References
1. Kanak, S.; Krzemińska, B.; Celiński, R.; Bakalczuk, M.; Dos Santos Szewczyk, K. Phenolic composition and antioxidant activity of Alchemilla Species. Plants 2022, 11, Art. No: 2709. DOI: 10.3390/plants11202709 DOI: https://doi.org/10.3390/plants11202709
2. Denev, P.; Kratchanova, M.; Ciz, M.; Lojek, A.; Vasicek, O.; Blazheva, D.; Nedelcheva, P.; Vojtek, L.; Hyrsl, P. Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts. Acta Biochim. Pol. 2014, 61, 359–367, DOI: 10.18388/abp.2014_1907 DOI: https://doi.org/10.18388/abp.2014_1907
3. Jurić, T.; Katanić Stanković, J.S.; Rosić, G.; Selaković, D.; Joksimović, J.; Mišić, D.; Stanković, V.; Mihailović, V. Protective effects of Alchemilla vulgaris L. extracts against cisplatin-induced toxicological alterations in rats. South African J. Bot. 2020, 128, 141–151, DOI: 10.1016/j.sajb.2019.09.010 DOI: https://doi.org/10.1016/j.sajb.2019.09.010
4. Neagu, E.; Paun, G.; Albu, C.; Radu, G.L. Assessment of acetylcholinesterase and tyrosinase inhibitory and antioxidant activity of Alchemilla vulgaris and Filipendula ulmaria extracts. J. Taiwan Inst. Chem. Eng. 2015, 52, 1–6, DOI:10.1016/j.jtice.2015.01.026 DOI: https://doi.org/10.1016/j.jtice.2015.01.026
5. Valcheva-Kuzmanova, S.; Denev, P.; Eftimov, M.; Georgieva, A.; Kuzmanova, V.; Kuzmanov, A.; Kuzmanov, K.; Tzaneva, M. Protective effects of Aronia melanocarpa juices either alone or combined with extracts from Rosa canina or Alchemilla vulgaris in a rat model of indomethacin-induced gastric ulcers. Food Chem. Toxicol. 2019, 132, Art. No: 110739, DOI: 10.1016/j.fct.2019.110739 DOI: https://doi.org/10.1016/j.fct.2019.110739
6. Nikolova, M.; Dincheva, I.; Vitkova, A.; Badjakov, I. Phenolic acids and free radical scavenging activity of Bulgarian endemic - Alchemilla jumrukczalica Pawl. Planta Med. 2011, 77, 10–13, DOI: 10.1055/s-0031-1282722 DOI: https://doi.org/10.1055/s-0031-1282722
7. El-Hadidy, E.M.; Refat, O.G.; Halaby, M.S.; Elmetwaly, E.M.; Omar, A.A. Effect of Lion’s Foot (Alchemilla vulgaris) on liver and renal functions in rats induced by CCl4. Food Nutr. Sci. 2018, 09, 46–62, DOI: 10.4236/fns.2018.91004 DOI: https://doi.org/10.4236/fns.2018.91004
8. Ibrahim, O.H.M.; Abo-Elyousr, K.A.M.; Asiry, K.A.; Alhakamy, N.A.; Mousa, M.A.A. Phytochemical characterization, antimicrobial activity and in vitro antiproliferative potential of Alchemilla vulgaris Auct root extract against prostate (PC-3), breast (MCF-7) and colorectal adenocarcinoma (Caco-2) cancer cell lines. Plants 2022, 11(16), Art. No: 2140, DOI: 10.3390/plants11162140 DOI: https://doi.org/10.3390/plants11162140
9. Duckstein, S.M.; Lotter, E.M.,;Meyer, U.; Lindequist, U. Phenolic constituents from Alchemilla vulgaris L. Zeitschrift für Naturforsch. C 2012, 67, 529–540. DOI: 10.5560/ZNC.2012.67c0529 DOI: https://doi.org/10.1515/znc-2012-11-1201
10. Ilić-Stojanović, S.; Nikolić, V.; Kundaković, T.; Savić, I.; Savić-Gajić, I.; Jocić, E.; Nikolić, L. Thermosensitive hydrogels for modified release of ellagic acid obtained from Alchemilla vulgaris L. extract. Int. J. Polym. Mater. Polym. Biomater. 2018, 67, 553–563, DOI: 10.1080/00914037.2017.1354202 DOI: https://doi.org/10.1080/00914037.2017.1354202
11. Møller, C.; Hansen, S.H.; Cornett, C. Characterisation of tannin-containing herbal drugs by HPLC. Phytochem. Anal. 2009, 20, 231–239, DOI: 10.1002/pca.1119 DOI: https://doi.org/10.1002/pca.1119
12. Ravetto Enri, S.; Falla, N.M.; Demasi, S.; Bianchi, D.M.; Squadrone, S.; Lombardi, G.; Scariot, V. Exploring the potential of wild leafy vegetables widespread in European Alps as functional food. J. Agric. Food Res. 2024, 18, Art. No: 101368. DOI: 10.1016/j.jafr.2024.101368 DOI: https://doi.org/10.1016/j.jafr.2024.101368
13. Szewczyk, K.D.S.; Pietrzak, W.; Klimek, K.; Grzywa‐celińska, A.; Celiński, R.; Gogacz, M. LC‐ESI‐MS/MS Identification of biologically active phenolics in different extracts of Alchemilla acutiloba Opiz. Molecules 2022, 27, Art. No:621 DOI:10.3390/molecules27030621 DOI: https://doi.org/10.3390/molecules27030621
14. Tasić-Kostov, M.; Arsić, I.; Pavlović, D.; Stojanović, S.; Najman, S.; Naumović, S.; Tadić, V. Towards a modern approach to traditional use: In vitro and in vivo evaluation of Alchemilla vulgaris L. Gel wound healing potential. J. Ethnopharmacol. 2019, 238,
Art. No:111789 DOI:10.1016/j.jep.2019.03.016 DOI: https://doi.org/10.1016/j.jep.2019.03.016
15. Condrat, D.; Mosoarca, C.; Zamfir, A.D.; Crişan, F.; Szabo, M.R.; Lupea, A.X. Qualitative and quantitative analysis of gallic acid in Alchemilla vulgaris, Allium ursinum, Acorus calamus and Solidago virga-aurea by chip-electrospray Ionization Mass Spectrometry and High Performance Liquid Chromatography. Cent. Eur. J. Chem. 2010, 8, 530–535, DOI:10.2478/s11532-010-0012-4 DOI: https://doi.org/10.2478/s11532-010-0012-4
16. Şeker Karatoprak, G.; İlgün, S.; Koşar, M. Phenolic composition, anti-inflammatory, antioxidant, and antimicrobial activities of Alchemilla mollis (Buser) Rothm. Chem. Biodivers. 2017, 14, Art. No: 1700150, DOI:10.1002/cbdv.201700150
17. Snarska, J.; Jakimiuk, K.; Strawa, J.W.; Tomczyk, T.M.; Tomczykowa, M.; Piwowarski, J.P.; Tomczyk, M. A Comprehensive Review of Pedunculagin: Sources, Chemistry, Biological and Pharmacological Insights. Int. J. Mol. Sci. 2024, 25, Art. No: 11511,
DOI: 10.3390/ijms252111511 DOI: https://doi.org/10.3390/ijms252111511
18. Özbilgin, S.; Özbek, H.; Kirmizi, N.İ.; Ergene Öz, B.; Kurtul, E.; Özrenk, B.C.; Saltan İşcan, G.; Bahadir Acikara, Ö. Evaluation of the antidiabetic activity of Alchemilla persica Rothm. in mice with diabetes induced by alloxan. Turkish J. Pharm. Sci. 2019, 16, 261–264, DOI: 10.4274/tjps.galenos.2018.65487 DOI: https://doi.org/10.4274/tjps.galenos.2018.65487
19. Suručić, R.; Radović Selgrad, J.; Kundaković-Vasović, T.; Lazović, B.; Travar, M.; Suručić, L.; Škrbić, R. In silico and in vitro studies of Alchemilla viridiflora Rothm—polyphenols’ potential for inhibition of SARS-CoV-2 internalization. Molecules 2022, 27,
Art. No: 5174, DOI:10.3390/molecules27165174 DOI: https://doi.org/10.3390/molecules27165174
20. Geiger, C.; Scholz, E.; Rimpler, H. Ellagitannins from Alchemilla xanthochlora and Potentilla erecta. Planta Med. 1994, 60, 384–385, DOI: 10.1055/s-2006-959510 DOI: https://doi.org/10.1055/s-2006-959510
21. Öz, B.E.; Ilhan, M.; Özbilgin, S.; Akkol, E.K.; Acıkara, Ö.B.; Saltan, G.; Keleş, H.; Süntar, I. Effects of Alchemilla mollis and Alchemilla persica on the wound healing process. Bangladesh J. Pharmacol. 2016, 11, 577–584, DOI: 10.3329/bjp.v11i3.26024 DOI: https://doi.org/10.3329/bjp.v11i3.26024
22. Radović, J.; Suručić, R.; Niketić, M.; Kundaković-Vasović, T. Alchemilla viridiflora Rothm.: the potent natural inhibitor of angiotensin I-converting enzyme. Mol. Cell. Biochem. 2022, 477, 1893–1903, DOI: 10.1007/s11010-022-04410-7 DOI: https://doi.org/10.1007/s11010-022-04410-7
23. Jelača, S.; Dajić-Stevanović, Z.; Vuković, N.; Kolašinac, S.; Trendafilova, A.; Nedialkov, P.; Stanković, M.; Tanić, N.; Tanić, N.T.; Acović, A.; et al. Beyond traditional use of Alchemilla vulgaris. Molecules 2022, 27 (23), Art. No: 8113, DOI:10.3390/molecules27238113 DOI: https://doi.org/10.3390/molecules27238113
24. Grochowski, D.M.; Skalicka-Woźniak, K.; Orhan, I.E.; Xiao, J.; Locatelli, M.; Piwowarski, J.P.; Granica, S.; Tomczyk, M. A comprehensive review of agrimoniin. Ann. N. Y. Acad. Sci. 2017, 1401, 166–180, DOI: 10.1111/nyas.13421 DOI: https://doi.org/10.1111/nyas.13421
25. Ghedira, K.; Goetz, P.; Le Jeune, R. Alchemilla vulgaris L.: Alchémille (Rosaceae). Phytotherapie 2012, 10, 263–266, DOI:10.1007/s10298-012-0719-9 DOI: https://doi.org/10.1007/s10298-012-0719-9
26. Renda, G.; Özel, A.; Barut, B.; Korkmaz, B.; Šoral, M.; Kandemir, Ü.; Liptaj, T. Bioassay guided isolation of active compounds from Alchemilla barbatiflora Juz. Rec. Nat. Prod. 2018, 12, 76–85, DOI: 10.25135/rnp.07.17.07.117 DOI: https://doi.org/10.25135/rnp.07.17.07.117
27. Karaoglan, E.S.; Bayir, Y.; Albayrak, A.; Toktay, E.; Ozgen, U.; Kazaz, C.; Kahramanlar, A.; Cadirci, E. Isolation of major compounds and gastroprotective activity of Alchemilla caucasica on indomethacin induced gastric ulcers in rats. Eurasian J. Med. 2020, 52, 249–253, DOI:10.5152/eurasianjmed.2020.19243 DOI: https://doi.org/10.5152/eurasianjmed.2020.19243
28. Şeker Karatoprak, G.; İlgün, S.; Koşar, M. Phenolic composition, anti-inflammatory, antioxidant, and antimicrobial activities of Alchemilla mollis (Buser) Rothm. Chem. Biodivers. 2017, 14, Art. No: 1700150 DOI:10.1002/cbdv.201700150 DOI: https://doi.org/10.1002/cbdv.201700150
29. Kurtul, E.; Eryilmaz, M.; Sarialtin, S.Y.; Teki̇n, M.; Acikara, Ö.B.; Çoban, T. Bioactivities of Alchemilla mollis, Alchemilla persica and their active constituents. Brazilian J. Pharm. Sci. 2022, 58, Art. No: 18373. DOI: 10.1590/s2175-97902022e18373 DOI: https://doi.org/10.1590/s2175-97902022e18373
30. Mladenova, S.G.; Vasileva, L. V.; Savova, M.S.; Marchev, A.S.; Tews, D.; Wabitsch, M.; Ferrante, C.; Orlando, G.; Georgiev, M.I. Anti-adipogenic effect of Alchemilla monticola is mediated via PI3K/AKT signaling inhibition in human adipocytes. Front. Pharmacol. 2021, 12, Art. No: 707507. DOI:10.3389/fphar.2021.707507 DOI: https://doi.org/10.3389/fphar.2021.707507
31. Shrivastava, R.; John, G.W. Treatment of aphthous stomatitis with topical Alchemilla vulgaris in glycerine. Clin. Drug Investig. 2006, 26, 567–573, DOI: 10.2165/00044011-200626100-00003 DOI: https://doi.org/10.2165/00044011-200626100-00003
32. Felser, C.; Schimmer, O. Flavonoid glycosides from Alchemilla speciosa. Planta Med. 1999, 65, 668–670, DOI: 10.1055/s-2006-960845 DOI: https://doi.org/10.1055/s-2006-960845
33. Mandrone, M.; Coqueiro, A.; Poli, F.; Antognoni, F.; Choi, Y.H. Identification of a collagenase-inhibiting flavonoid from Alchemilla vulgaris using NMR-based metabolomics. Planta Med. 2018, 84, 941–946, DOI:10.1055/a-0630-2079 DOI: https://doi.org/10.1055/a-0630-2079
34. Vlaisavljević, S.; Jelača, S.; Zengin, G.; Mimica-Dukić, N.; Berežni, S.; Miljić, M.; Stevanović, Z.D. Alchemilla vulgaris Agg. (Lady’s Mantle) from Central Balkan: antioxidant, anticancer and enzyme inhibition properties. RSC Adv. 2019, 9, 37474–37483, DOI: 10.1039/c9ra08231j DOI: https://doi.org/10.1039/C9RA08231J
35. Ahn, H.S.; Kim, H.J.; Na, C.; Jang, D.S.; Shin, Y.K.; Lee, S.H. The protective effect of Adenocaulon himalaicum Edgew. and its bioactive compound neochlorogenic acid against UVB-induced skin damage in human dermal fibroblasts and epidermal keratinocytes. Plants 2021, 10(8), Art. No: 1669,
DOI: 10.3390/plants10081669 DOI: https://doi.org/10.3390/plants10081669
36. Kang, W.; Choi, D.; Park, T. Decanal protects against UVB-induced photoaging in human dermal fibroblasts via the camp pathway. Nutrients 2020, 12,
Art. No:1214 DOI:10.3390/nu12051214 DOI: https://doi.org/10.3390/nu12051214
37. Larka, R.; Kiran, M.S.; Korrapati, P.S. Collagen scaffold reinforced with furfural for wound healing application. Materials Letters 2022, 315, Art. No: 131956 DOI:10.1016/j.matlet.2022.131956 DOI: https://doi.org/10.1016/j.matlet.2022.131956
38. Cheng, H.M.; Chen, F.Y.; Li, C.C.; Lo, H.Y.; Liao, Y.F.; Ho, T.Y.; Hsiang, C.Y. Oral administration of vanillin improves imiquimod-induced psoriatic skin inflammation in mice. J. Agric. Food Chem. 2017, 65, 10233–10242, DOI:10.1021/acs.jafc.7b04259 DOI: https://doi.org/10.1021/acs.jafc.7b04259
39. Dubel, N.; Grytsyk, L.; Kovaleva, A.; Grytsyk, A.; Коshovyi, О. Research in components of essential oils from flowers and leaves of the genus Alchemilla L. Species. Sci. Pharm. Sci. 2022, 2022, 34–39, DOI:10.15587/2519-4852.2022.259059 DOI: https://doi.org/10.15587/2519-4852.2022.259059
40. Huang, Z.R.; Lin, Y.K.; Fang, J.Y. Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology. Molecules 2009, 14(1), 540–554,
DOI: 10.3390/molecules14010540 DOI: https://doi.org/10.3390/molecules14010540
41. Wolski, T.; Kędzia, B. Farmakoterapia skóry. Cz. 2. Przenikanie substancji przez skórę. Pharmacotherapy of skin. Part 2. Permeability of substances into the skin. Postępy Fitoterapii, 2019, 2, 154-158, DOI: 10.25121/PF.2019.20.2.154 DOI: https://doi.org/10.25121/PF.2019.20.2.154
42. https://powo.science.kew.org (data dostępu 30.11.2024).
43. Hoffmann, J.; Casetti, F.; Bullerkotte, U.; Haarhaus, B.; Vagedes, J.; Schempp, C.M.; Wölfle, U. Anti-inflammatory effects of agrimoniin-enriched fractions of Potentilla erecta. Molecules 2016, 21, Art. No:792, DOI:10.3390/molecules21060792 DOI: https://doi.org/10.3390/molecules21060792
44. Majma Sanaye, P.; Mojaveri, M.R.; Ahmadian, R.; Sabet Jahromi, M.; Bahramsoltani, R. Apigenin and its dermatological applications: a comprehensive review. Phytochemistry 2022, 203, Art. No: 113390, DOI: 10.1016/j.phytochem.2022.113390 DOI: https://doi.org/10.1016/j.phytochem.2022.113390
45. Zhao, D.; Shi, Y.; Dang, Y.; Zhai, Y.; Ye, X. Daidzein stimulates collagen synthesis by activating the TGF-β/Smad signal pathway. Australas. J. Dermatol. 2015, 56, e7–e14, DOI: 10.1111/ajd.12126 DOI: https://doi.org/10.1111/ajd.12126
46. Falchero, L.; Coppa, M.; Esposti, S.; Tava, A. Essential oil composition of Alchemilla alpina L. Em. Buser from Western Alpine Pastures. J. Essent. Oil Res. 2008, 20, 542–545, DOI: 10.1080/10412905.2008.9700084 DOI: https://doi.org/10.1080/10412905.2008.9700084
47. Nisar, M.F.; Liu, T.; Wang, M.; Chen, S.; Chang, L.; Karisma, V.W.; Weixu; Diao, Q.; Xue, M.; Tang, X.; et al. Eriodictyol protects skin cells from UVA irradiation-induced photodamage by inhibition of the MAPK signaling pathway. J. Photochem. Photobiol. B Biol. 2022, 226, Art. No: 112350. DOI:10.1016/j.jphotobiol.2021.112350 DOI: https://doi.org/10.1016/j.jphotobiol.2021.112350
48. Wei, H.; Saladi, R.; Lu, Y.; Wang, Y.; Palep, S.R.; Moore, J.; Phelps, R.; Shyong, E.; Lebwohl, M.G. Isoflavone genistein: photoprotection and clinical implications in dermatology. J. Nutr. 2003, 133, 3811S-3819S. DOI:10.1093/jn/133.11.3811s DOI: https://doi.org/10.1093/jn/133.11.3811S
49. Lu, Z.; Xia, Q.; Cheng, Y.; Lu, Q.; Li, Y.; Zeng, N.; Luan, X.; Li, Y.; Fan, L.; Luo, D. Hesperetin attenuates UVA-induced photodamage in human dermal fibroblast cells. J. Cosmet. Dermatol. 2022, 21, 6261–6269. DOI:10.1111/jocd.15230 DOI: https://doi.org/10.1111/jocd.15230
50. Goenka, S.; Ceccoli, J.; Simon, S.R. Anti-melanogenic activity of ellagitannin casuarictin in B16F10 mouse melanoma cells. Nat. Prod. Res. 2021, 35, 1830–1835. DOI:10.1080/14786419.2019.1636242 DOI: https://doi.org/10.1080/14786419.2019.1636242
51. Yoshino, S.; Mitoma, T.; Tsuruta, K.; Todo, H.; Sugibayashi, K. Effect of emulsification on the skin permeation and UV protection of catechin. Pharm. Dev. Technol. 2014, 19, 395–400. DOI: 10.3109/10837450.2013.788512 DOI: https://doi.org/10.3109/10837450.2013.788512
52. Liu, C.; Liu, H.; Lu, C.; Deng, J.; Yan, Y.; Chen, H.; Wang, Y.; Liang, C.L.; Wei, J.; Han, L.; et al. Kaempferol attenuates imiquimod-induced psoriatic skin inflammation in a mouse model. Clin. Exp. Immunol. 2019, 198, 403–415. DOI:10.1111/cei.13363 DOI: https://doi.org/10.1111/cei.13363
53. Tsang, M.S.M.; Jiao, D.; Chan, B.C.L.; Hon, K.L.; Leung, P.C.; Lau, C.B.S.; Wong, E.C.W.; Cheng, L.; Chan, C.K.M.; Lam, C.W.K.; et al. Anti-inflammatory activities of pentaherbs formula, berberine, gallic acid and chlorogenic acid in atopic dermatitis-like skin inflammation. Molecules 2016, 21, Art. No: 519. DOI: 10.3390/molecules21040519 DOI: https://doi.org/10.3390/molecules21040519
54. Gunia-Krzyżak, A.; Słoczyńska, K.; Popiół, J.; Koczurkiewicz, P.; Marona, H.; Pękala, E. Cinnamic acid derivatives in cosmetics: current use and future prospects. Int. J. Cosmet. Sci. 2018, 40, 356–366. DOI: 10.1111/ics.12471 DOI: https://doi.org/10.1111/ics.12471
55. Bae, J.Y.; Choi, J.S.; Kang, S.W.; Lee, Y.J.; Park, J.; Kang, Y.H. Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Exp. Dermatol. 2010, 19, 182–190. DOI: 10.1111/j.1600-0625.2009.01044.x DOI: https://doi.org/10.1111/j.1600-0625.2009.01044.x
56. Zduńska, K.; Dana, A.; Kolodziejczak, A.; Rotsztejn, H. Antioxidant properties of ferulic acid and its possible application. Skin Pharmacol. Physiol. 2018, 31, 332–336. DOI:10.1159/000491755 DOI: https://doi.org/10.1159/000491755
57. Alonso, C.; Martí, M.; Barba, C.; Lis, M.; Rubio, L.; Coderch, L. Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid. J. Photochem. Photobiol. B Biol. 2016, 156, 50–55, DOI: 10.1016/j.jphotobiol.2016.01.014 DOI: https://doi.org/10.1016/j.jphotobiol.2016.01.014
58. Song, H.S.; Park, T.W.; Sohn, U.D.; Shin, Y.K.; Choi, B.C.; Kim, C.J.; Sim, S.S. The effect of caffeic acid on wound healing in skin-incised mice. Korean J. Physiol. Pharmacol. 2008, 12, 343–347. DOI: 10.4196/kjpp.2008.12.6.343 DOI: https://doi.org/10.4196/kjpp.2008.12.6.343
59. Saija, A.; Tomaino, A.; Lo Cascio, R.; Trombetta, D.; Proteggente, A.; De Pasquale, A.; Uccella, N.; Bonina, F. Ferulic and caffeic acids as potential protective agents against photooxidative skin damage. J. Sci. Food Agric. 1999, 79, 476–480. DOI:10.1002/(SICI)1097-0010(19990301)79:3<476::AID-JSFA270>3.0.CO;2-L DOI: https://doi.org/10.1002/(SICI)1097-0010(19990301)79:3<476::AID-JSFA270>3.0.CO;2-L
60. Jacobs, S.W.; Culbertson, E.J. Effects of topical mandelic acid treatment on facial skin viscoelasticity. Facial Plast. Surg. 2018, 34, 651–656. DOI:10.1055/s-0038-1676048 DOI: https://doi.org/10.1055/s-0038-1676048
61. Boo, Y.C. P-Coumaric acid as an active ingredient in cosmetics: a review focusing on its antimelanogenic effects. Antioxidants 2019, 8, Art. No: 275 .DOI:10.3390/antiox8080275 DOI: https://doi.org/10.3390/antiox8080275
62. Shin, S.; Cho, S.H.; Park, D.; Jung, E. Anti-skin aging properties of protocatechuic acid in vitro and in vivo. J. Cosmet. Dermatol. 2020, 19, 977–984. DOI:10.1111/jocd.13086 DOI: https://doi.org/10.1111/jocd.13086
63. Lee, J.; Jung, E.; Koh, J.; Kim, Y.S.; Park, D. Effect of rosmarinic acid on atopic dermatitis. J. Dermatol. 2008, 35, 768–771. DOI: 10.1111/j.1346-8138.2008.00565.x DOI: https://doi.org/10.1111/j.1346-8138.2008.00565.x
64. Arif, T. Salicylic acid as a peeling agent: a comprehensive review. Clin. Cosmet. Investig. Dermatol. 2015, 8, 455–461. DOI: 10.2147/CCID.S84765 DOI: https://doi.org/10.2147/CCID.S84765
65. Jeon, J.; Sung, J.; Lee, H.; Kim, Y.; Jeong, H.S.; Lee, J. Protective activity of caffeic acid and sinapic acid against UVB-induced photoaging in human fibroblasts. J. Food Biochem. 2019, 43, Art. No: e12701. DOI:10.1111/jfbc.12701 DOI: https://doi.org/10.1111/jfbc.12701
66. Na, E.J.; Yang, H.O.; Choi, Y.E.; Han, H.S.; Rhie, S.J.; Ryu, J.Y. Anti-inflammatory and collagen production effect of syringic acid on human keratinocyte (HaCaT) damaged by ultraviolet B. Asian J. Beauty Cosmetol. 2018, 16, 523–531. DOI:10.20402/ajbc.2018.0245 DOI: https://doi.org/10.20402/ajbc.2018.0245
67. Erden Inal, M.; Kahraman, A.; Köken, T. Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clin. Exp. Dermatol. 2001, 26, 536–539. DOI:10.1046/j.1365-2230.2001.00884.x DOI: https://doi.org/10.1046/j.1365-2230.2001.00884.x
68. Gendrisch, F.; Esser, P.R.; Schempp, C.M.; Wölfle, U. Luteolin as a modulator of skin aging and inflammation. BioFactors 2021, 47, 170–180. DOI:10.1002/biof.1699 DOI: https://doi.org/10.1002/biof.1699
69. Hou, D.D.; Gu, Y.J.; Wang, D.C.; Niu, Y.; Xu, Z.R.; Jin, Z.Q.; Wang, X.X.; Li, S.J. Therapeutic effects of myricetin on atopic dermatitis in vivo and in vitro. Phytomedicine 2022, 102, Art. No: 154200. DOI:10.1016/j.phymed.2022.154200 DOI: https://doi.org/10.1016/j.phymed.2022.154200
70. Yong, H.J.; Ahn, J.J. Antioxidant and skin protection effect of morin upon UVA exposure. Biomed. Dermatol. 2018, 2, Art. No: 12. DOI: 10.1186/s41702-018-0026-7 DOI: https://doi.org/10.1186/s41702-018-0026-7
71. Al-Roujayee, A.S. Naringenin improves the healing process of thermally-induced skin damage in rats. J. Int. Med. Res. 2017, 45, 570–582. doi:10.1177/0300060517692483 DOI: https://doi.org/10.1177/0300060517692483
72. Ren, X.; Shi, Y.; Zhao, D.; Xu, M.; Li, X.; Dang, Y.; Ye, X. Naringin protects ultraviolet B-induced skin damage by regulating P38 MAPK signal pathway. J. Dermatol. Sci. 2016, 82, 106–114. doi: 10.1016/j.jdermsci.2015.12.008 DOI: https://doi.org/10.1016/j.jdermsci.2015.12.008
73. Kim, M.; Yin, J.; Hwang, I.H.; Park, D.H.; Lee, E.K.; Kim, M.J.; Lee, M.W. Anti-acne vulgaris effects of pedunculagin from the leaves of Quercus mongolica by anti-inflammatory activity and 5α-reductase inhibition. Molecules 2020, 25 (9), Art. No: 2154. doi: 10.3390/molecules25092154. DOI: https://doi.org/10.3390/molecules25092154
74. Lee, O.; Choi, M.; Ha, S.; Lee, G.; Kim, J.; Park, G.; Lee, M.; Choi, Y.; Kim, M.; Oh, C.H. Effect of pedunculagin investigated by non-invasive evaluation on atopic-like dermatitis in NC/Nga Mice. Ski. Res. Technol. 2010, 16, 371–377. DOI: 10.1111/j.1600-0846.2010.00443.x DOI: https://doi.org/10.1111/j.1600-0846.2010.00443.x
75. Takahashi, T.; Kamimura, A.; Kagoura, M.; Toyoda, M.; Morohashi, M. Investigation of the topical application of procyanidin oligomers from apples to identify their potential use as a hair‐growing agent. J. Cosmet. Dermatol. 2005, 4, 245–249. DOI:10.1111/j.1473-2165.2005.00199.x DOI: https://doi.org/10.1111/j.1473-2165.2005.00199.x
76. Ratz-Łyko, A.; Arct, J. Resveratrol as an active ingredient for cosmetic and dermatological applications: a review. J. Cosmet. Laser Ther. 2019, 21(2), 84-90. DOI: 10.1080/14764172.2018.1469767 DOI: https://doi.org/10.1080/14764172.2018.1469767
77. McBride, P.T.; Clark, L.; Krueger, G.G. Evaluation of triacontanol-containing compounds as anti-inflammatory agents using guinea pig models. J. Invest. Dermatol. 1987, 89, 380–383. DOI: 10.1111/1523-1747.ep12471763 DOI: https://doi.org/10.1111/1523-1747.ep12471763
78. Jouravel, G.; Guénin, S.; Bernard, F.X.; Elfakir, C.; Bernard, P.; Himbert, F. New biological activities of Lythrum salicaria L.: effects on keratinocytes, reconstructed epidermis and reconstructed skins, applications in dermo-cosmetic sciences. Cosmetics 2017, 4 (4), Art. No: 52 DOI: 10.3390/cosmetics4040052 DOI: https://doi.org/10.3390/cosmetics4040052
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Sebastian Kanak, Barbara Krzemińska

This work is licensed under a Creative Commons Attribution 4.0 International License.
For all articles published in Prospects in Pharmaceutical Sciences copyright is retained by the authors. The journal publishes articles in the Open Access policy, within the CC BY 4.0 licence.
This is a human-readable summary of (and not a substitute for) the license. Disclaimer.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.