Published : 2024-09-18

Renaissance of Ketamine

Kinga Kocur

Katarzyna Camlet

Anna Ziobro

Mateusz Ziomek

Wojciech Kaźmierski

Paulina Lis

Jakub Jurek

Anna Lis

Abstract

The history of ketamine began in the 1960s. Ketamine is a specific anesthetic drug that exhibits analgesia, has a stabilizing impact on the cardiovascular system and does not significantly depress the respiratory system. It is responsible for causing the so-called dissociative effect. The effects of ketamine depend on the dose. Its mechanism of action is based primarily on the blockade of N-methyl D-aspartic acid receptors (NMDA) in the central nervous system. Due to its favorable action profile and small number of contraindications, ketamine is becoming an increasingly popular drug. In medicine, it is commonly used as an analgesic and an anesthetic. Studies conducted over recent years have noted that it can be effective in conditions such as: status epilepticus, status asthmaticus, agitation, alcohol dependence and alcohol withdrawal syndrome, depression, and suicidal thoughts. This paper reviews current reports on the uses of ketamine, beneficial especially to physicians with the specialty in emergency medicine.

Keywords:

ketamine, status epilepticus, agitation, analgesia, depression


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Kocur, K., Katarzyna Camlet, Anna Ziobro, Mateusz Ziomek, Wojciech Kaźmierski, Paulina Lis, … Anna Lis. (2024). Renaissance of Ketamine. Prospects in Pharmaceutical Sciences, 22(3), 156–163. https://doi.org/10.56782/pps.242

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Stefana Banacha 1
02-097 Warsaw, Poland
biuletynfarmacji@wum.edu.pl
Publisher:
Medical University of Warsaw
ul. Żwirki i Wigury 61
02-091 Warszawa

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