Renaissance of Ketamine

Kinga Kocur; Katarzyna Camlet; Anna Ziobro; Mateusz Ziomek; Wojciech Kaźmierski; Paulina Lis; Jakub Jurek; Anna Lis

doi:10.56782/pps.242

Published : 2024-09-18

Vol. 22 No. 3 (2024)

Renaissance of Ketamine

Kinga Kocur

Katarzyna Camlet

Anna Ziobro

Mateusz Ziomek

Wojciech Kaźmierski

Paulina Lis

Jakub Jurek

Anna Lis

DOI: https://doi.org/10.56782/pps.242

Abstract

The history of ketamine began in the 1960s. Ketamine is a specific anesthetic drug that exhibits analgesia, has a stabilizing impact on the cardiovascular system and does not significantly depress the respiratory system. It is responsible for causing the so-called dissociative effect. The effects of ketamine depend on the dose. Its mechanism of action is based primarily on the blockade of N-methyl D-aspartic acid receptors (NMDA) in the central nervous system. Due to its favorable action profile and small number of contraindications, ketamine is becoming an increasingly popular drug. In medicine, it is commonly used as an analgesic and an anesthetic. Studies conducted over recent years have noted that it can be effective in conditions such as: status epilepticus, status asthmaticus, agitation, alcohol dependence and alcohol withdrawal syndrome, depression, and suicidal thoughts. This paper reviews current reports on the uses of ketamine, beneficial especially to physicians with the specialty in emergency medicine.

Keywords:

ketamine, status epilepticus, agitation, analgesia, depression

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Kocur, K., Katarzyna Camlet, Anna Ziobro, Mateusz Ziomek, Wojciech Kaźmierski, Paulina Lis, Jakub Jurek, & Anna Lis. (2024). Renaissance of Ketamine. Prospects in Pharmaceutical Sciences, 22(3), 156–163. https://doi.org/10.56782/pps.242

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Kinga Kocur

kingakocur98@wp.pl

Affiliation:

a:1:{s:5:"en_US";s:59:"District Hospital in Oświęcim, 32-600, Oświęcim, Poland";} Poland

Katarzyna Camlet

katarzyna.camlet@gmail.com

Affiliation:

District Hospital in Zakopane, Kamieniec 10, 34-500 Zakopane, Poland Poland

Anna Ziobro

aannaziobro@gmail.com

Affiliation:

District Hospital in Zakopane, 34-500, Zakopane, Poland Poland

Mateusz Ziomek

mateusz.ziomek98@gmail.com

Affiliation:

Military Institute of Medicine - National Research Institute, 04-141, Warsaw, Poland Poland

Wojciech Kaźmierski

wkazmierski97@gmail.com

Affiliation:

Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705, Krakow, Poland. Poland

Paulina Lis

lispaulinab@gmail.com

Affiliation:

Leszek Giec Upper-Silesian Medical Centre of the Medical University of Silesia in Katowice, 40-635 Katowice, Poland. Poland

Jakub Jurek

kubajurek1999@gmail.com

Affiliation:

Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705, Krakow, Poland. Poland

Anna Lis

lis.anna9898@gmail.com

Affiliation:

Leszek Giec Upper-Silesian Medical Centre of the Medical University of Silesia in Katowice, 40-635 Katowice, Poland. Poland