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The role of serum procalcitonin as a diagnostic marker in patients with dengue: a review
Szymon Barczak
Zuzanna Hertz
Barbara Badura
Abstract
Dengue is the most rapidly spreading vector-borne disease in the world. An estimated 2.5 billion people live in dengue-endemic countries. Most cases of dengue are asymptomatic; however, the disease can progress to a severe cases with plasma leakage, hemorrhage, and shock. The treatment options are limited and are focused mostly on supportive care. Procalcitonin is regarded as a biomarker specific for bacterial infections. The current literature contains only five papers addressing the topic of the clinical relevance of serum procalcitonin in patients with dengue. Serum procalcitonin levels tend to be elevated in patients who experience organ failure, shock, or dengue hemorrhagic fever; however, this difference was not statistically significant in all studies. Serum procalcitonin demonstrated strong diagnostic utility for detecting bacterial coinfection or bacteremia, and can be used to exclude bacteremia in dengue patients. The majority of the reviewed studies involved small sample sizes, which often precluded reaching statistical significance. The utility of serum procalcitonin as a diagnostic marker in patients with dengue remains insufficiently explored, and further research is necessary to fully understand its clinical role.
Keywords:
dengue, procalcitonin, tropical diseases, hemorrhagic fever, diagnostic markerMost read articles by the same author(s)
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