Synthesis of 7-(2,3-epoxypropoxy)coumarin derivatives and evaluation of their radical-scavenging properties by EPR spectroscopy

Kinga Ostrowska; Alicja Duszek; Magdalena Kołodziejska; Katerina Makarova

doi:10.56782/pps.676

Published : 2025-10-05

Vol. 24 No. 1 (2026)

Synthesis of 7-(2,3-epoxypropoxy)coumarin derivatives and evaluation of their radical-scavenging properties by EPR spectroscopy

Kinga Ostrowska

Alicja Duszek

Magdalena Kołodziejska

Katerina Makarova

DOI: https://doi.org/10.56782/pps.676

Abstract

Coumarin derivatives are known for their broad biological activities, particularly their ability to influence oxidative stress pathways. In this work, a new series of 7-(2,3-epoxypropoxy)coumarin derivatives was synthesized and fully characterized by NMR and HRMS. The structural modification introduced a 3’-ethoxy-2’-hydroxypropoxy fragment, and the compounds were evaluated for their ability to modulate hydroxyl and methyl radical formation in the Fenton reaction using Electron Paramagnetic Resonance (EPR) spectroscopy. Comparative analysis revealed that derivative 1 and its precursor a (6-acetyl-4-methyl-7-(oxiran-2-ylmethoxy)-2H-chromen-2-one) exhibited the most pronounced radical-scavenging activity, demonstrating stronger antioxidant effects than their corresponding substrates. These findings highlight coumarin epoxide derivatives as promising scaffolds for redox-modulating agents, and confirm the utility of EPR as a sensitive tool for probing antioxidant potential.

Keywords:

coumarin, Electron Paramagnetic Resonance

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Ostrowska, K., Duszek, A., Kołodziejska, M., & Makarova, K. (2025). Synthesis of 7-(2,3-epoxypropoxy)coumarin derivatives and evaluation of their radical-scavenging properties by EPR spectroscopy. Prospects in Pharmaceutical Sciences, 24(1), 71–81. https://doi.org/10.56782/pps.676

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Kinga Ostrowska

kostrowska@wum.edu.pl

Affiliation:

a:1:{s:5:"en_US";s:120:"Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland. ";} Poland

Alicja Duszek

alicja.duszek24@gmail.com

Bio Statement (e.g., department and rank)

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.

Magdalena Kołodziejska

s082139@student.wum.edu.pl

Bio Statement (e.g., department and rank)

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.

Katerina Makarova

katerina.makarova@wum.edu.pl

Bio Statement (e.g., department and rank)

Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, 02-097 Warsaw, Poland.

Synthesis of 7-(2,3-epoxypropoxy)coumarin derivatives and evaluation of their radical-scavenging properties by EPR spectroscopy

Kinga Ostrowska

Alicja Duszek

Magdalena Kołodziejska

Katerina Makarova

Abstract

Keywords:

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