Evaluation of the effectiveness of platelet-rich plasma therapy in the treatment of osteoarthritis compared to other treatment methods

Katarzyna Łysiak; Anna Łysiak; Magdalena Makarewicz; Barbara Maziarz

doi:10.56782/pps.231

Published : 2024-10-29

Vol. 22 No. 4 (2024)

Evaluation of the effectiveness of platelet-rich plasma therapy in the treatment of osteoarthritis compared to other treatment methods

Katarzyna Łysiak

Anna Łysiak

Magdalena Makarewicz

Barbara Maziarz

DOI: https://doi.org/10.56782/pps.231

Abstract

Osteoarthritis is a common condition affecting a large proportion of the population. It is associated with a significant reduction in quality of life due to pain and limited joint mobility. There are many methods of treatment, among them conservative methods, pharmacological or surgical treatment can be mentioned. The purpose of this article is to analyze the effectiveness of intra-articular injections of platelet-rich plasma (prp) compared to other methods. Platelet-rich plasma is widely used in the treatment of osteoarthritis. Many sources prove its effectiveness in reducing pain, compared to injections of other substances, but there are also studies about the lack of sufficient evidence or the effect of prp similar to the placebo effect. The use of platelet-rich plasma is a promising method of treating osteoarthritis, however, further research and long-term observations are needed to introduce this method to the standards of treatment. The article was based on scientific publications in the Pubmed database. The database was searched on July 28 2023 using the phrases 'osteoarthritis', ‘PRP’, ‘Platelet-rich plasma’. After reading the titles of found articles, 39 publications were selected. After the pre-analysis of the abstracts, 15 full-text works were selected to prepare the article.

Keywords:

osteoarthritis, PRP, platelet-rich plasma

Similar Articles

<< < 1 2

You may also start an advanced similarity search for this article.

Details

References

Statistics

Authors

Download files

PDF (Język Polski)

Citation rules

Łysiak, K., Łysiak, A., Makarewicz, M., & Maziarz, B. (2024). Evaluation of the effectiveness of platelet-rich plasma therapy in the treatment of osteoarthritis compared to other treatment methods. Prospects in Pharmaceutical Sciences, 22(4), 39–43. https://doi.org/10.56782/pps.231

Altmetric indicators

Cited by / Share

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License.

References

1.Goodman, S. Osteoarthritis. In Expert Guide to Rheumatology, Yee, A., Paget, S., Eds.; American College of Physicians: Philadelphia, PA, USA, 2005; pp. 269–283.

2. Bansal, H.; Leon, J.; Pont, J.L.; Wilson, D.A.; Bansal, A.; Agarwal, D.; Preoteasa, I. Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy. Sci. Rep. 2021, 11, Art. No: 3971. DOI: 10.1038/s41598-021-83025-2. Erratum in: Sci. Rep. 2021, 11, Art. No: 18612.

3. DiCesare, P.E.; Abramson, S.; Samuels, J. Pathogenesis of osteoarthritis. In Kelley's Textbook of Rheumatology, 8th ed.; Firestein, G.S.; Kelley, W.N., Eds.; Saunders Elsevier: Philadelphia, PA, USA, 2009; pp.1685-1704.

4. Cook, C.S.; Smith, P.A. Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee. Curr. Rev. Musculoskelet. Med. 2018, 11, 583-592. DOI: 10.1007/s12178-018-9524-x.

5. Manek, N.J.; Lane, N.E. Osteoarthritis: current concepts in diagnosis and management. Am. Fam. Physician. 2000, 61, 1795-1804.

6. Sinusas, K. Osteoarthritis: diagnosis and treatment. Am. Fam. Physician. 2012, 85, 49-56. Erratum in: Am. Fam. Physician. 2012, 86, 893.

7. Emami, A.; Tepper, J.; Short, B.; Yaksh, T.L.; Bendele, A.M.; Ramani, T.; Cisternas, A.F.; Chang, J.H.; Mellon, R.D. Toxicology Evaluation of Drugs Administered via Uncommon Routes: Intranasal, Intraocular, Intrathecal/Intraspinal, and Intra-Articular. Int. J. Toxicol. 2018, 37, 4–27. DOI: 10.‌11‌‌77‌‌/‌‌10‌9‌‌‌‌1‌‌5‌‌8181‌‌7‌741840.

8. Testa, G.; Giardina, S.M.C.; Culmone, A.; Vescio, A.; Turchetta, M.; Cannavò, S.; Pavone, V. Intra-Articular Injections in Knee Osteoarthritis: A Review of Literature. J. Funct. Morphol. Kinesiol. 2021, 6, Art. No: 15. DOI: 10.3390/jfmk6010015.

9. Jones, I.A.; Togashi, R.; Wilson, M.L.; Heckmann, N.; Vangsness, C.T. Jr. Intra-articular treatment options for knee osteoarthritis. Nat. Rev. Rheumatol. 2019, 15, 77-90. DOI: 10.1038/s41584-018-0123-4.

10. El-Kadiry, A.E.; Lumbao, C.; Salame, N.; Rafei, M.; Shammaa, R. Bone marrow aspirate concentrate versus platelet-rich plasma for treating knee osteoarthritis: a one-year non-randomized retrospective comparative study. BMC Musculoskelet Disord. 2022, 23, Art. No: 23. DOI: 10.1186/s12891-021-04910-5.

11. Xie, X.; Zhang, C.; Tuan, R.S. Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res. Ther. 2014, 16, Art. No: 204. DOI: 10.1186/ar4493.

12. Szwedowski, D.; Szczepanek, J.; Paczesny, Ł.; Zabrzyński, J.; Gagat, M.; Mobasheri, A.; Jeka, S. The Effect of Platelet-Rich Plasma on the Intra-Articular Microenvironment in Knee Osteoarthritis. Int. J. Mol. Sci. 2021, 22, Art. No: 5492. DOI: 10.3390/ijms22115492.

13. Khoshbin, A.; Leroux, T.; Wasserstein, D.; Marks, P.; Theodoropoulos, J.; Ogilvie-Harris, D.; Gandhi, R.; Takhar, K.; Lum, G.; Chahal, J. The Efficacy of Platelet-Rich Plasma in the Treatment of Symptomatic Knee Osteoarthritis: A Systematic Review With Quantitative Synthesis. Arthroscopy. 2013, 29, 2037–2048. DOI: 10.1016/j.arthro.2013.09.006.

14. Marmotti, A.; Rossi, R.; Castoldi, F,.; et al. PRP and articular cartilage: a clinical update. Biomed. Res. Int. 2015, 2015, Art. No: 542502. DOI: doi: 10.1155/2015/542502

15. Dohan Ehrenfest, D.M.; Andia, I.; Zumstein, M.A.; Chang-Qing, Z.; Pinto, N.R.; Bielecki, T. Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014, 4, 3-9.

16. Filardo, G.; Kon, E.; Pereira Ruiz, M.; Vaccaro, F.; Guitaldi, R.; Di Martino, A.; et al. Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach. Knee Surg. Sports Traumatol. Arthrosc. 2011, 20, 2082–2091. DOI: 10.1007/s00167-011-1837-x.

17. Braun, H.; Kim, H.; Chu, C.; Dragoo, J. The effect of platelet-rich plasma formulations and blood products on human synoviocytes. Am. J. Sports Med. 2014, 42, 1204–1210. DOI: 10.1177/0363546514525593.

18. Petrella, R.J.; Petrella, M. A prospective, randomized, double-blind, placebo controlled study to evaluate the efficacy of intraarticular hyaluronic acid for osteoarthritis of the knee. J. Rheumatol. 2006, 33, 951-956.

19. Cerza, F.; Carnì, S.; Carcangiu, A.; Di Vavo, I.; Schiavilla, V.; Pecora, A.; De Biasi, G.; Ciuffreda, M. Comparison between hyaluronic acid and platelet-rich plasma, intra-articular infiltration in the treatment of gonarthrosis. Am. J. Sports Med. 2012, 40, 2822-2827. DOI: 10.1177/0363546512461902.

20. Dold, A.P.; Zywiel, M.G.; Taylor, D.W.; Dwyer, T.; Theodoropoulos, J. Platelet-rich plasma in the management of articular cartilage pathology: a systematic review. Clin. J. Sport Med. 2014, 24, 31-43. DOI: 10.1097/01.jsm.0000432855.85143.e5.

21. Abhishek, A.; Doherty, M. Mechanisms of the placebo response in pain in osteoarthritis. Osteoarthr. Cartil. 2013, 21, 1229–1235. DOI: 10.1016/j.joca.‌‌‌2013.04.018.

22. Bennell, K.L.; Paterson, K.L.; Metcalf, B.R.; Duong, V.; Eyles, J.; Kasza, J.; Wang, Y.; Cicuttini, F.; Buchbinder, R.; Forbes, A.; Harris, A.; Yu, S.P.; Connell, D.; Linklater, J.; Wang, B.H.; Oo, W.M.; Hunter, D.J. Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial. JAMA. 2021, 326, 2021-2030. DOI: 10.1001/jama.2021.19415.

23. Filardo, G.; Previtali, D.; Napoli, F.; Candrian, C.; Zaffagnini, S.; Grassi, A. PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials. Cartilage. 2021, 13, 364S-375S. DOI: 10.1177/1947603520931170.

24. Zhao, J.; Huang, H.; Liang, G.; Zeng, L.F.; Yang, W.; Liu, J. Effects and safety of the combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of knee osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2020, 21, Art. No: 224. DOI: 10.1186/s12891-020-03262-w.

25. Raeissadat, S.A.; Ghazi Hosseini, P.; Bahrami, M.H.; Salman Roghani, R.; Fathi, M.; Gharooee Ahangar, A.; Darvish, M. The comparison effects of intra-articular injection of Platelet Rich Plasma (PRP), Plasma Rich in Growth Factor (PRGF), Hyaluronic Acid (HA), and ozone in knee osteoarthritis; a one year randomized clinical trial. BMC Musculoskelet Disord. 2021, 22, Art. No: 134. DOI: 10.1186/s12891-021-04017-x.

26. Joshi Jubert, N.; Rodríguez, L.; Reverté-Vinaixa, M.; Navarro, A. Platelet-rich plasma injections for advanced knee osteoarthritis: a prospective, randomized, double-blinded clinical trial. Orthop. J. Sports Med. 2017, 5, Art. No: 232596711668938. DOI: 10.1177/2325967116689386.

27. Phillips, M.; Bhandari, M.; Grant, J.; Bedi, A.; Trojian, T.; Johnson, A.; Schemitsch, E. A Systematic Review of Current Clinical Practice Guidelines on Intra-articular Hyaluronic Acid, Corticosteroid, and Platelet-Rich Plasma Injection for Knee Osteoarthritis: An International Perspective. Orthop. J. Sports Med. 2021, 9, Art. No: 23259671211030272. DOI: 10.1177/23259671211030272.

28. Shahid, M.; Kundra, R. Platelet-rich plasma (PRP) for knee disorders. EFORT Open Rev. 2017, 2, 28-34. DOI: 10.1302/2058-5241.2.160004.

Katarzyna Łysiak

kas.lysiak@gmail.com

Affiliation:

a:1:{s:5:"en_US";s:140:"Stefan Cardinal Wyszynski Provincial Specialist Hospital Independent Public Health Care Center in Lublin, al. Kraśnicka 100, 20-718 Lublin ";} Poland

Anna Łysiak

ann.lysiak@gmail.com
https://orcid.org/0009-0002-1157-9081

Affiliation:

Independent Public Clinical Hospital No. 4 in Lublin, ul. Doktora Kazimierza Jaczewskiego 8, 20-954 Lublin Poland

Magdalena Makarewicz

m.makarewicz.97@gmail.com
https://orcid.org/0000-0003-0485-8998

Affiliation:

Puławy Hospital – Independent Public Health Care Institution, Józefa Bema 1, 24-100 Puławy Poland

Barbara Maziarz

basssmaz@gmail.com
https://orcid.org/0000-0002-8339-1187

Affiliation:

Independent Public Clinical Hospital named after Prof. Orlowski, Center for Postgraduate Medical Education in Warsaw, ul. Czerniakowska 231, 00-416 Warszawa Poland