Natural- and in vitro-grown Filipendula ulmaria (L.) Maxim: evaluation of pharmaceutical potential (antibacterial, antioxidant and toxicity) and phenolic profiles

Arzu Birinci Yildirim; Ayca Cimen; Yavuz Baba; Arzu Turker

doi:10.56782/pps.171

Data publikacji : 2024-02-04

Tom 22 Nr 1 (2024)

Natural- and in vitro-grown Filipendula ulmaria (L.) Maxim: evaluation of pharmaceutical potential (antibacterial, antioxidant and toxicity) and phenolic profiles

Arzu Birinci Yildirim

Ayca Cimen

Yavuz Baba

Arzu Turker

DOI: https://doi.org/10.56782/pps.171

Abstrakt

Meadowsweet (Filipendula ulmaria (L.) Maxim) is Rosaceae family perennial herb. Traditional uses of F. ulmaria include inflammatory problems like rheumatism, arthrosis, and arthritis), gastrointestinal disorders, liver malfunction, and gout. The pharmaceutical industry has been very interested in this plant because of its health benefits. The presence of phenolic secondary metabolites is thought to be the primary cause of meadowsweet's biological activity and therapeutic efficacy. This study was intended to compare and evaluate the biological activities (antibacterial, antioxidant, antitumor and toxicity) and phenolic profiles (total phenol-flavonoid content and individual phenolic constituents) of F. ulmaria aerial parts obtained from two different sources (naturally- and in vitro-grown). Antibacterial activity was evaluated using 17 different bacteria (10 human and 7 fish pathogens) with disc diffusion method. Methanolic extracts of in vitro-grown parts showed higher antibacterial effect than naturally-grown parts with all tested bacterial pathogens (human and fish). On the other hand, other extracts (aqueous, ethanol, hexane, and ethyl acetate) demonstrated higher antibacterial potential with field-grown parts. The highest sensitivity was observed with Staphylococcus epidermidis, S. aureus and Enterobacter cloacae to aqueous extract of field-grown plants. The potent antibacterial activity of F. ulmaria extracts rendered the Agrobacterium tumefaciens-induced potato disc tumor assay inapplicable. Toxicity assay (brine shrimp) showed that aqueous extract of both sources had the lowest toxicity. Methanolic extract of both parts had a strong antioxidant potential (DPPH radical scavenging activty) having IC₅₀ values as 205.65 µg/mL and 206.74 µg/mL, respectively, and similar level of overall total phenol-flavonoid contents. Individual phenolic analysis with HPLC-DAD showed that the most prevalent phenol was rutin in both sources. While the quantities of chlorogenic acid in both aerial parts were similar, the parts that were grown naturally had higher levels of salicylic acid and rutin. These findings demonstrated the effective antibacterial and antioxidant properties, high phenolic content, and low toxicity of both F. ulmaria sources, indicating that they can be utilized in nutraceutical industry due to their high health promoting potential.

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Birinci Yildirim, A., Cimen, A., Baba, Y., & Turker, A. (2024). Natural- and in vitro-grown Filipendula ulmaria (L.) Maxim: evaluation of pharmaceutical potential (antibacterial, antioxidant and toxicity) and phenolic profiles. Prospects in Pharmaceutical Sciences, 22(1), 1–10. https://doi.org/10.56782/pps.171

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Bibliografia

Davis, P. H. Flora of Turkey and the East Aegean Islands; Edinburgh Univ. Press: Edinburgh, 1972. http://www.jstor.org/stable/10.3366/j.ctvxcrc36

Lindeman, A.; Jounela-Eriksson, P.; Lounasmaa, M. The aroma composition of the flower of Meadowsweet (Filipendula ulmaria L. Maxim.). Lebensm.-Wiss. Technol. 1982, 15, 286-89.

Grieve, M. A modern herbal; Dover Publications: New York, 1982.

Dobelis, I. N. Magic and Medicine of Plants; The Reader’s Digest Association: New York, 1990.

Chevallier, A. The Encyclopedia of Medicinal Plants; Darling Kindersley Limited: London, 1996.

Baytop, T. Turkiye’de bitkiler ile tedavi; Nobel Tıp Kitabevleri: İstanbul, 1999.

Farzaneh, A.; Hadjiakhoondi, A.; Khanavi, M.; Manayi, A.; Bahram Soltani, R. Filipendula ulmaria (L.) Maxim.(Meadowsweet): a Review of Traditional Uses, Phytochemistry and Pharmacology. Res. J. Pharmacogn. 2022, 9(3), 85-106. https://doi.org/10.22127/rjp.2021.302028.1781

Katanić, J.; Boroja, T.; Stanković, N.; Mihailović, V.; Mladenović, M.; Kreftb, S.; Vrvićc, M. M. Bioactivity, stability and phenolic characterization of Filipendula ulmaria (L.) Maxim. Food Funct. 2015, 6, 1164–1175. https://doi.org/10.1039/c4fo01208a DOI: https://doi.org/10.1039/C4FO01208A

Falowo, A. B.; Fayemi, P. O.; Muchenje, V. Natural antioxidants against lipid–protein oxidative deterioration in meat and meat products: A review. Food Res. Int. 2014, 64, 171-181. https://doi.org/10.1016/j.foodres.2014.06.022 DOI: https://doi.org/10.1016/j.foodres.2014.06.022

Barros, L.; Cabrita, L.; Boas, M. V.; Carvalho, A. M.; Ferreira, I. C. Chemical, biochemical and electrochemical assays to evaluate phytochemicals and antioxidant activity of wild plants. Food Chem. 2011, 127(4), 1600-1608. http://dx.doi.org/10.1016/j.foodchem.2011.02.024 DOI: https://doi.org/10.1016/j.foodchem.2011.02.024

Baranenko, D.; Bespalov, V.; Nadtochii, L.; Shestopalova, I.; Chechetkina, A.; Lepeshkin, A.; Ilina, V. Development of encapsulated extracts on the basis of meadowsweet (Filipendula ulmaria) in the composition of functional foods with oncoprotective properties. Agron. Res. 2019, 17(5), 1829–1838. https://doi.org/10.15159/ar.19.155

Mostafa, A. A.; Al-Askar, A. A.; Almaary, K. S.; Dawoud, T. M.; Sholkamy, E. N.; Bakri, M. M. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi J. Biol. Sci. 2018, 25(2), 361-366. https://doi.org/10.1016/j.sjbs.2017.02.004 DOI: https://doi.org/10.1016/j.sjbs.2017.02.004

Pandey, A. K.; Kumar, P.; Singh, P.; Tripathi, N. N.; Bajpai, V. K. Essential oils: Sources of antimicrobials and food preservatives. Front. Microbiol. 2017, 7, 2161. https://doi.org/10.3389%2Ffmicb.2016.02161 DOI: https://doi.org/10.3389/fmicb.2016.02161

Rauha, J. P.; Remes, S.; Heinonen, M.; Hopia, A.; Kähkönen, M.; Kujala, T.; Pihlaja, K.; Vuorela, H.; Vuorela, P. Antimicrobial effects of Finnish plant extracts containing flavonoids and other phenolic compounds. Int. J. Food Microbiol. 2000, 56(1), 3-12. https://doi.org/10.1016/s0168-1605(00)00218-x DOI: https://doi.org/10.1016/S0168-1605(00)00218-X

Smolarz, H. D.; Sokolowska-Wozniak, A. Pharmacological effects of extracts from Filipendula ulmaria and Filipendula hexapetala. Postepy Fitoterapii. 2001, 2 (7): 16-19.

Spiridonov, N. A.; Konovalov, D. A.; Arkhipov, V. V. Cytotoxicity of some Russian ethnomedicinal plants and plant compounds. Phytother. Res. 2005, 19(5), 428-432. https://doi.org/10.1002/ptr.1616 DOI: https://doi.org/10.1002/ptr.1616

Bespalov, V. G.; Alexandrov, V. A.; Semenov, A. L.; Vysochina, G. I.; Kostikova, V. A.; Baranenko, D. A. The inhibitory effect of Filipendula ulmaria (L.) Maxim. on colorectal carcinogenesis induced in rats by methylnitrosourea. J. Ethnopharmacol. 2018, 227, 1-7. https://doi.org/10.1016/j.jep.2018.08.013 DOI: https://doi.org/10.1016/j.jep.2018.08.013

Pesmen, H.; Chamberlain, D. F. Flora of Turkey and the East Aegean Islands; Edinburgh University Press: Edinburgh, 1972.

Yıldırım, A. B.; Turker, A. U. In vitro adventitious shoot regeneration of the medicinal plant meadowsweet (Filipendula ulmaria (L.) Maxim). In Vitro Cell. Dev. Biol. 2009, 45, 135-144. http://dx.doi.org/10.1007/s11627-009-9194-x DOI: https://doi.org/10.1007/s11627-009-9194-x

Turker, A. U.; Yildirim, A. B.; Tas, I.; Ozkan, E.; Turker, H. Evaluation of some traditional medicinal plants: phytochemical profile, antibacterial and antioxidant potentials. Rom Biotechnol Lett. 2021, 26(2), 2499-2510. http://dx.doi.org/10.25083/rbl/26.2/2499.2510 DOI: https://doi.org/10.25083/rbl/26.2/2499.2510

Andrews, J. M. BSAC Standardized Disc Susceptibility Testing Method (Version 8). J. Antimicrob. Chemother. 2009, 64, 454–489. https://doi.org/10.1093/jac/dkp244 DOI: https://doi.org/10.1093/jac/dkp244

Meyer, B. N.; Ferrigni, N. R.; Putham, J. E.; Jacobsen, L. B.; Nichols, D. E.; McLaughlin, J. L. Brine Shrimp: A convenient general bioassay for active plant constituents. J. Med. Plants Res. 1982, 45, 31-34. https://doi.org/10.1055/s-2007-971236 DOI: https://doi.org/10.1055/s-2007-971236

Sam, T. W. Toxicity testing using the brine shrimp: Artemia salina; CRC Press: United States, 1993.

Ferrigini, N. R.; Putnam, J. E.; Anderson, B.; Jacobsen, L. B.; Nichols, D. E.; Moore, D. S.; McLaughlin, J. L. Modification and evaluation of the potato disc assay and antitumor screening of Euphorbia seeds. J. Nat. Prod. 1982, 45, 679-686. https://doi.org/10.1021/np50024a005 DOI: https://doi.org/10.1021/np50024a005

McLaughlin, J. L.; Chang, C. J.; Smith, D. L. “Bench-top” bioassays for the discovery of bioactive natural products: Elsevier Science Publishing Company Inc: New York, 1991.

Coker, P. S.; Radecke, J.; Guy, C.; Camper, N. D. Potato disc tumor induction assay: A multiple mode of drug action assay. Phytomedicine. 2003, 10, 133-138. https://doi.org/10.1078/094471103321659834 DOI: https://doi.org/10.1078/094471103321659834

Blois, M.S. Antioxidant determinations by the use of a stable free radical. Nat. 1958, 181, 1199. https://doi.org/10.1038/1811199a0 DOI: https://doi.org/10.1038/1811199a0

Turker, H.; Yildirim, A. B.; Karakaş, F. P. Sensitivity of bacteria isolated from fish to some medicinal plants. Turkish J. Fish. Aquat. Sci. 2009, 9(2). http://doi.org/10.4194/trjfas.2009.0209 DOI: https://doi.org/10.4194/trjfas.2009.0209

Denev, P.; Kratchanova, M.; Ciz, M.; Lojek, A.; Vasicek, O.; Blazheva, D.; Nedelcheva, P.; Vojtek, L.; Hyrsl, P. Antioxidant, antimicrobial and neutrophil-modulating activities of herb extracts. Acta Biochim. Pol. 2014, 61(2), 359-367. http://dx.doi.org/10.18388/abp.2014_1907 DOI: https://doi.org/10.18388/abp.2014_1907

Sokolov, N. S.; Sharipova, S. K.; Sazanova, K. N.; Lyamin, A. V. A comparative evaluation of the antimicrobial activity of aqueous extracts from aerial organs of meadowsweet (Filipendula ulmaria (L.) Maxim.) and dropwort (Filipendula hexapetala Gilib.). Aspirantskiy Vestnik Povolzhiya, 2022, 22(4), 63-68. http://dx.doi.org/10.55531/2072-2354.2022.22.4.63-68 DOI: https://doi.org/10.55531/2072-2354.2022.22.4.63-68

Savina, T.; Lisun, V.; Feduraev, P.; Skrypnik, L. Variation in Phenolic Compounds, Antioxidant and Antibacterial Activities of Extracts from Different Plant Organs of Meadowsweet (Filipendula ulmaria (L.) Maxim.). Mol. 2023, 28(8), 3512. https://doi.org/10.3390/molecules28083512 DOI: https://doi.org/10.3390/molecules28083512

Woods-Panzaru, S.; Nelson, D.; McCollum, G.; Ballard, L. M.; Millar, B. C.; Maeda, Y.; Goldsmith, C.E.; Rooney, P. J.; Loughrey, A.; Rao, J. R.; Moore, J. E. An examination of antibacterial and antifungal properties of constituents described in traditional Ulster cures and remedies. Ulster Med J. 2009, 78(1), 13-15.

Göç, F.; Erel, E.; Sarı, A. Plants used in Traditional Treatment for Boils in Turkey. J. Tradit. Complement. Med. 2021, 2(1), 49-61.

Cowan, M. M. Plant products as antimicrobial agents. Clin. Microbiol. Rev. 1999, 12(4), 564-582. https://doi.org/10.1128/cmr.12.4.564 DOI: https://doi.org/10.1128/CMR.12.4.564

Scherer, R.; Godoy, H. T. Effects of extraction methods of phenolic compounds from Xanthium strumarium L. and their antioxidant activity. Rev. Bras. Plant. Med. 2014, 16(1), 41-46. http://dx.doi.org/10.1590/S1516-05722014000100006 DOI: https://doi.org/10.1590/S1516-05722014000100006

Pukalskiene, M.; Venskutonis, P. R.; Pukalskas, A. Phytochemical characterization of Filipendula ulmaria by UPLC/Q-TOF-MS and evaluation of antioxidant activity. Rec. Nat. Prod. 2015, 9(3), 451-455.

Sukhikh, S.; Ivanova, S.; Skrypnik, L.; Bakhtiyarova, A.; Larina, V.; Krol, O.; Prosekov A.; Frolov A.; Povydysh, M.; Babich, O. Study of the Antioxidant Properties of Filipendula ulmaria and Alnus glutinosa. Plants. 2022, 11(18), 2415. https://doi.org/10.3390/plants11182415 DOI: https://doi.org/10.3390/plants11182415

Neagu, E.; Paun, G.; Albu, C.; Radu, G. L. Assessment of acetylcholinesterase and tyrosinase inhibitory and antioxidant activity of Alchemilla vulgaris and Filipendula ulmaria extracts. J. Taiwan Inst. Chem. Eng. 2015, 52, 1-6. https://doi.org/10.1016/j.jtice.2015.01.026 DOI: https://doi.org/10.1016/j.jtice.2015.01.026

Harbourne, N.; Marete, E.; Jacquier, J. C.; O'Riordan, D. Effect of drying methods on the phenolic constituents of meadowsweet (Filipendula ulmaria) and willow (Salix alba). LWT- Food Sci. Technol. 2009, 42(9), 1468-1473. https://doi.org/10.1016/j.lwt.2009.05.005 DOI: https://doi.org/10.1016/j.lwt.2009.05.005

Papastavropoulou, K.; Oz, E.; Oz, F.; Proestos, C. Polyphenols from plants: Phytochemical characterization, antioxidant capacity, and antimicrobial activity of some plants from different sites of Greece. Separations. 2022, 9(8), 186. http://dx.doi.org/10.3390/separations9080186 DOI: https://doi.org/10.3390/separations9080186

Proestos, C.; Boziaris, I. S.; Kapsokefalou, M.; Komaitis, M. Natural antioxidant constituents from selected aromatic plants and their antimicrobial activity against selected pathogenic microorganisms. Food Technol. Biotechnol. 2008, 46(2), 151-156.

Arzu Birinci Yildirim

Afiliacja:

Department of Field Crops, Faculty of Agriculture, Bolu Abant Izzet Baysal University, 14030 Bolu, Türkiye Turkey

Ayca Cimen

Afiliacja:

Department of Biology, Faculty of Arts and Sciences, Bolu Abant Izzet Baysal University, 14030 Bolu, Türkiye Turkey

Yavuz Baba

Afiliacja:

Department of Biology, Faculty of Arts and Sciences, Bolu Abant Izzet Baysal University, 14030 Bolu, Türkiye Turkey

Arzu Turker

turker_a@ibu.edu.tr

Afiliacja:

a:1:{s:5:"en_US";s:57:"Bolu Abant Izzet Baysal University, Department of Biology";} Turkey