Published : 2016-12-02

VEMURAFENIB AS A SELECTIVE INHIBITOR OF THE SERINE/THREONINE-PROTEIN KINASE B-RAF, USED IN THE TREATMENT OF MELANOMA

Krzysztof Kubica

Aleksander Mazurek

Abstract

Protein kinases are now the second most important group of proteins targeted in molecular-level anticancer therapies. Inhibiting the activity of protein kinases emerged as an important aspect of anticancer therapy. Vemurafenib is particularly effective in treating melanoma because its inhibitory activity is limited only to the B-RAF protein. It has relatively minor side effects. The biggest problem is an increasing resistance of tumor cells to this drug. The solution may involve combination therapies that will likely constitute the preferred future treatment of melanoma by inhibitors of protein kinases.

Keywords:

melanoma, protein kinases, protein kinase inhibitors, vemurafenib



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Kubica, K., & Mazurek, A. (2016). VEMURAFENIB AS A SELECTIVE INHIBITOR OF THE SERINE/THREONINE-PROTEIN KINASE B-RAF, USED IN THE TREATMENT OF MELANOMA. Prospects in Pharmaceutical Sciences, 14(8), 52–56. https://doi.org/10.56782/pps.117

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Editorial Team
Stefana Banacha 1
02-097 Warsaw, Poland
biuletynfarmacji@wum.edu.pl
Publisher:
Medical University of Warsaw
ul. Żwirki i Wigury 61
02-091 Warszawa

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