Enhancing water solubility of a BCS Class II drug using hydrotropy, mixed solvency, co-solvency, and nanosuspension techniques
DOI:
https://doi.org/10.56782/pps.500Keywords:
Diclofenac sodium, Hydrotropy, Nanosuspension, Co-solvency, Solubility enhancementAbstract
Diclofenac sodium, a BCS Class II drug, exhibits high permeability but poor solubility, limiting its bioavailability. This study investigates solubility enhancement techniques such as hydrotropy, co-solvency, mixed solvency, and nanosuspension using agents such as urea, sodium acetate, sodium citrate, polyethylene glycol 400 (PEG 400), and glycerin at concentrations of 10–60 ppm. Solubility was evaluated via Shimadzu UV-1800 UV-Vis spectrophotometry. All methods showed a linear increase in solubility, with nanosuspension demonstrating the highest enhancement. The eco-friendly, non-toxic agents used make these techniques suitable for pharmaceutical applications. Overall, the findings support nanosuspension as a promising strategy to improve the bioavailability and therapeutic efficacy of poorly soluble drugs like diclofenac sodium.
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Copyright (c) 2025 Vijayraj Sonawane, Dhanashree I. Wagh, Sakshi P. Bhamare, Khemchand R. Surana, Deepak D. Sonawane, Sunil K. Mahajan
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