Published : 2025-10-11

Quercetin from edible Rutaceae plants: phytochemical profiling and therapeutic applications

Suman Ghosh

Ishita Debnath

Prerona Saha

Abstract

The Rutaceae family comprises several edible plants with high quercetin content, a bioactive flavonol recognized for its diverse therapeutic properties. This review specifically focuses on profiling quercetin in edible Rutaceae species available in West Bengal, emphasizing part-wise distribution (leaves, peels, fruits), extraction techniques, and pharmacological relevance. Among the species evaluated, Citrus sinensis and Aegle marmelos demonstrated the highest quercetin concentrations in leaves and peels, correlating strongly with their antioxidant, antidiabetic, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, and anticancer properties. These mechanisms of action are linked to key molecular pathways, including NF-κB, Nrf2, PI3K/Akt, and AMPK. Methanolic extraction emerged as the most effective method for quercetin recovery across most species. Critical evaluation revealed notable knowledge gaps in bioavailability enhancement strategies, standardization across species, and clinical validation. By narrowing the scope exclusively to quercetin and its therapeutic functions, this review offers a targeted resource for future pharmacognostic exploration, bioavailability studies, and quercetin-based phytopharmaceutical development.

Keywords:

Quercetin, Rutaceae, West Bengal, Mechanism of action, Bioavailability, Phytochemical Profiling


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Ghosh, S., Debnath, I., & Saha, P. (2025). Quercetin from edible Rutaceae plants: phytochemical profiling and therapeutic applications. Prospects in Pharmaceutical Sciences, (2025 (Early Access). https://doi.org/10.56782/pps.581

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Editorial Team
Stefana Banacha 1
02-097 Warsaw, Poland
biuletynfarmacji@wum.edu.pl
Publisher:
Medical University of Warsaw
ul. Żwirki i Wigury 61
02-091 Warszawa

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