PODWYŻSZONE STĘŻENIE HOMOCYSTEINY WE KRWI  JAKO WSKAŹNIK ZAGROŻENIA ZDROWIA

Sylwia Kraczkowska; Zofia Suchocka; Jan Pachecka

doi:10.56782/pps.54

Published : 2005-12-28

Vol. 3 No. 3 (2005)

ELEVATED BLOOD LEVEL OF HOMOCYSTEINE AS INDICATOR OF HEALTH HAZARD

Sylwia Kraczkowska

Zofia Suchocka

Jan Pachecka

DOI: https://doi.org/10.56782/pps.54

Abstract

Elevated plasma level of homocysteine (hyperhomocysteinemia) is considered as an independent risk factor for cardiovascular diseases (vascular thrombosis, myocardial infarctions, strokes), neurodegenerative diseases (Alzheimer and Parkinson disease), neural tube defects, danger of spontaneous abortion and carcinomas (especially colon carcinoma). It has been observed that one in ten inhabitants of Europe shows increased plasma homocysteine concentration which is connected with higher risk of cardiovascular diseases development, as myocardial infarction or ischaemic strokes. Pregnant women with hyperhomocysteinemia are exposed to hypertension and neural tube defects of fetus. Elevated plasma levels of homocysteine were found in patients with chronic renal failure, hypothyroidism, several types of carcinomas, pernicious anemia, liver disfunctions and in patients with hypovitaminosis, especially folic acid deficiencies. It has been established that 25% reduction of plasma homocysteine concentration can decrease the risk of myocardial infarction of about 11%, stroke of about 19% and can essentially lower the frequency fetal defects. Authorities still quarrel over the best method of treatement, however it is suggested that witamins B₁₂, B₆ as well as the supplementation with folic acid are generally effective in reducing homocysteine level. Recently, dieticians campaign for flours’ supplementation with folic acid. This article aims at stressing the role of hyperhomocysteinemia in etiology of several dangerous civilization diseases.

Keywords:

homocysteine, hyperhomocysteinemia, folic acid, cardiovascular diseases

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Kraczkowska, S., Suchocka, Z., & Pachecka, J. (2005). ELEVATED BLOOD LEVEL OF HOMOCYSTEINE AS INDICATOR OF HEALTH HAZARD. Prospects in Pharmaceutical Sciences, 3(3), 19–24. https://doi.org/10.56782/pps.54

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Sylwia Kraczkowska

Affiliation:

Katedra i Zakład Biochemii i Chemii Klinicznej, Wydział Farmaceutyczny Akademii Medycznej w Warszawie Poland

Zofia Suchocka

Affiliation:

Katedra i Zakład Biochemii i Chemii Klinicznej, Wydział Farmaceutyczny Akademii Medycznej w Warszawie Poland

Jan Pachecka

Affiliation:

Katedra i Zakład Biochemii i Chemii Klinicznej, Wydział Farmaceutyczny Akademii Medycznej w Warszawie Poland