The therapeutic potential of mesenchymal stromal cells and their secretome in sport-related injuries
DOI:
https://doi.org/10.56782/pps.271Keywords:
sport injury, mesenchymal stromal cells, cartilage defect, ligament injury, MSCs secretomeAbstract
As the prevalence of sports-related injuries continues to rise, there is an urgent need for innovative therapeutic strategies that not only expedite recovery but also enhance the quality of healing. The application of mesenchymal stromal cells (MSCs) therapy in the treatment of sports injuries represents a groundbreaking advancement in the field of regenerative medicine. This review aims to summarize and discuss the therapeutic effects of MSCs in facilitating tissue regeneration and expediting the healing process following sports-related injuries. It also aims to highlight current research findings regarding the efficacy, safety and administration routes in clinical MSCs therapy trials. Data was obtained by searching Pubmed and Google Scholar, using the keywords: ‘sport injury, ‘Osteoarthritis’, ‘mesenchymal stromal/stem cells’, ‘tendon’, ‘cartilage defect’, ‘ligament injury’, ‘MSC secretome’, ‘conditioned medium’. According to the U. S. National Library of Medicine, there have been a total of 7,146 registered clinical trials worldwide on stem cell therapy till 5/10/2024, with 1,626 specifically focusing on MSCs therapy. The safety and efficacy of MSCs and MSCs secretome therapies in treating sport-related injuries have been shown in many preclinical studies. The promising outcomes observed in experimental studies have propelled the transition to clinical trials, which have also shown positive results. MSCs therapy has the potential to accelerate healing processes, reduce downtime, and allow athletes to return to their sport faster and with greater confidence. This is crucial not only for professional athletes but also for recreational sports enthusiasts who seek to maintain an active lifestyle. However, bone marrow mesenchymal stromal cells (BM-MSCs), umbilical cord mesenchymal stromal cells (UCB-MSCs) and adipose-derived mesenchymal stromal cells (AD-MSCs) were predominantly utilized in these trials, indicating that there is unexplored therapeutic potential of MSCs from other sources. This review not only aims to contribute valuable knowledge to the field, but also aspires to inspire further exploration and innovation in the use of MSCs for enhancing athletic performance and recovery.
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