MODELE ODDZIAŁYWAŃ LIGANDÓW ARYLOPIPERAZYNYLOWYCH  Z RECEPTORAMI SEROTONINOWYMI 5-HT1A, 5-HT2A I 5-HT7

Anna Bielenica; Jerzy Kossakowski

doi:10.56782/pps.67

Published : 2010-03-23

Vol. 8 No. 2 (2010)

BINDING MODES OF LONG-CHAIN ARYLPIPERAZINES TO 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS

Anna Bielenica

Jerzy Kossakowski

DOI: https://doi.org/10.56782/pps.67

Abstract

The objective of this article is a presentation of selected docking models of long-chain arylpiperazines to 5-HT_1A, 5-HT_2Aand 5-HT₇ receptors. The most important types of interactions stabilizing the ligand-receptor complex were described. Several hypotheses proposed on the basis of homological modeling were discussed. In order to determine conformations of known alkyl- and alkoxypiperazinyl ligands, structural data from Cambridge Structural Database were analyzed.

Keywords:

docking, LCAPs, 5-HT1A receptor, 5-HT2A receptor and 5-HT7 receptor

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Anna Bielenica, Jerzy Kossakowski, COMPUTATIONAL METHODS IN DETERMINATION OF PHARMACOPHORE MODELS OF 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS. , Prospects in Pharmaceutical Sciences: Vol. 8 No. 1 (2010)

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Bielenica, A., & Kossakowski, J. (2010). BINDING MODES OF LONG-CHAIN ARYLPIPERAZINES TO 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS. Prospects in Pharmaceutical Sciences, 8(2), 13–21. https://doi.org/10.56782/pps.67

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Anna Bielenica

Affiliation:

Katedra i Zakład Chemii Medycznej, I Wydział Lekarski Warszawski Uniwersytet Medyczny, Poland

Jerzy Kossakowski

Affiliation:

Katedra i Zakład Chemii Medycznej, I Wydział Lekarski Warszawski Uniwersytet Medyczny, Poland