COMPUTATIONAL METHODS IN DETERMINATION OF PHARMACOPHORE MODELS OF 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS.
DOI:
https://doi.org/10.56782/pps.65Keywords:
pharmacophore models, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptorAbstract
The objective of this article is an overview of existing pharmacophore models for 5-HT1A, 5-HT2A and 5-HT7 receptors, which have been described during the last decade. Models of 5-HT1A and 5-HT2A receptors, developed by conformational analysis and 3D QSAR methods are presented. Hypotheses of the ligand-5-HT7 receptor interaction were complemented by models constructed on the basis of the receptor’s structure. Various pharmacophore concepts are characterized by structures of known active ligands and sets of compounds used for the generation of models.
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