ZASTOSOWANIE METOD OBLICZENIOWYCH DO WYZNACZANIA BUDOWY  MODELI FARMAKOFOROWYCH RECEPTORÓW 5-HT1A, 5-HT2A ORAZ 5-HT7

Anna Bielenica; Jerzy Kossakowski

doi:10.56782/pps.65

Published : 2010-03-23

Vol. 8 No. 1 (2010)

COMPUTATIONAL METHODS IN DETERMINATION OF PHARMACOPHORE MODELS OF 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS.

Anna Bielenica

Jerzy Kossakowski

DOI: https://doi.org/10.56782/pps.65

Abstract

The objective of this article is an overview of existing pharmacophore models for 5-HT_1A, 5-HT_2Aand 5-HT₇ receptors, which have been described during the last decade. Models of 5-HT_1A and 5-HT_2Areceptors, developed by conformational analysis and 3D QSAR methods are presented. Hypotheses of the ligand-5-HT₇ receptor interaction were complemented by models constructed on the basis of the receptor’s structure. Various pharmacophore concepts are characterized by structures of known active ligands and sets of compounds used for the generation of models.

Keywords:

pharmacophore models, 5-HT1A receptor, 5-HT2A receptor, 5-HT7 receptor

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Anna Bielenica, Jerzy Kossakowski, BINDING MODES OF LONG-CHAIN ARYLPIPERAZINES TO 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS , Prospects in Pharmaceutical Sciences: Vol. 8 No. 2 (2010)

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Bielenica, A., & Kossakowski, J. (2010). COMPUTATIONAL METHODS IN DETERMINATION OF PHARMACOPHORE MODELS OF 5-HT1A, 5-HT2A AND 5-HT7 RECEPTORS. Prospects in Pharmaceutical Sciences, 8(1), 1–12. https://doi.org/10.56782/pps.65

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Anna Bielenica

Affiliation:

Katedra i Zakład Chemii Medycznej, I Wydział Lekarski, Warszawski Uniwersytet Medyczny, Poland

Jerzy Kossakowski

Affiliation:

Katedra i Zakład Chemii Medycznej, I Wydział Lekarski, Warszawski Uniwersytet Medyczny, Poland