Dapagliflozin - new solution in chronic kidney disease treatment

Maciej Bara; Jakub Starownik; Jakub Szydło; Patryk Gryszkiewicz; Jakub Nieznański

doi:10.56782/pps.195

Data publikacji : 2024-06-05

Tom 22 Nr 2 (2024)

Dapagliflozin - new solution in chronic kidney disease treatment

Maciej Bara

Jakub Starownik

Jakub Szydło

Patryk Gryszkiewicz

Jakub Nieznański

DOI: https://doi.org/10.56782/pps.195

Abstrakt

Despite being developed relatively recently, SGLT2 inhibitors have proven to be versatile pharmaceuticals useful in treatment of diabetes mellitus, heart failure and chronic kidney disease. Extensive and ongoing studies confirm more and more of their beneficial effects on metabolic, cardiovascular and renal health. Most of the conducted studies focused on patients suffering from diabetes mellitus type 2. Recent study, DAPA - CKD, published in the New England Journal of Medicine confirmed dapagliflozin’s beneficial effect on chronic kidney disease of any etiology. This discovery has cemented flozins’ status as nephroprotective drugs and led to a new indication of use for dapagliflozin - chronic kidney disease. In Poland treatment of chronic kidney disease with dapagliflozin is reimbursed in patients with chronic kidney disease with eGFR <60 ml/min/1.73m2, albuminuria or proteinuria who were treated with ACEi/ARB for ≥4 weeks or with contraindications for ACEi/ARB therapy. Due to reimbursement, dapagliflozin therapy is financially available for a wide population of patients and, in light of recent discoveries, should be considered by clinicians.

Słowa kluczowe:

dapagliflozin, chronic kidney disease, SGLT2 inhibitors, nephrology

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Bara, M., Starownik, J., Szydło, J., Gryszkiewicz, P., & Nieznański, J. (2024). Dapagliflozin - new solution in chronic kidney disease treatment. Prospects in Pharmaceutical Sciences, 22(2), 59–64. https://doi.org/10.56782/pps.195

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Maciej Bara

maaciej.bara@gmail.com
https://orcid.org/0000-0001-7238-2237

Afiliacja:

Infant Jesus Clinical Hospital, Medical University of Warsaw, 02-005 Warsaw, Poland. Poland

Jakub Starownik

https://orcid.org/0009-0008-2711-2578

Afiliacja:

Military Institute of Medicine - National Research Institute, 04-141 Warsaw, Poland. Poland

Jakub Szydło

https://orcid.org/0009-0009-1092-2571

Afiliacja:

Infant Jesus Clinical Hospital, Medical University of Warsaw, 02-005 Warsaw, Poland. Poland

Patryk Gryszkiewicz

https://orcid.org/0009-0004-2671-0374

Afiliacja:

Infant Jesus Clinical Hospital, Medical University of Warsaw, 02-005 Warsaw, Poland. Poland

Jakub Nieznański

https://orcid.org/0009-0000-5908-493X

Afiliacja:

Independent Public Health Care Complex in Minsk Mazowiecki, 05-300 Minsk Mazowiecki, Poland Poland