Sodium-Glucose Cotransporter-2 Inhibitors In Heart Failure

Wojciech Kaźmierski; Jakub Jurek; Paulina Lis; Anna Lis; Anna Ziobro; Mateusz Ziomek; Katarzyna Camlet; Kinga Kocur

doi:10.56782/pps.240

Published : 2024-09-26

Vol. 22 No. 3 (2024)

Sodium-glucose cotransporter2 inhibitors in heart failure

Wojciech Kaźmierski

Jakub Jurek

Paulina Lis

Anna Lis

Anna Ziobro

Mateusz Ziomek

Katarzyna Camlet

Kinga Kocur

DOI: https://doi.org/10.56782/pps.240

Abstract

Heart failure (HF) is a serious problem in a modern world, with increasing prevalence among ageing populations. The use of sodium-glucose cotransporter2 (SGLT2) inhibitors, originally intended to treat type 2 diabetes, has revolutionised the treatment of HF. In this review article, we present the latest evidence on the mechanism of action of SGLT2 inhibitors, also called flosins, in HF. The primary mechanism of action of flosins is to reduce glucose reabsorption from glomerular filtration in the proximal renal tubule with a concomitant reduction in sodium reabsorption, leading to urinary glucose excretion and osmotic diuresis. Based on experimental findings, several pleiotropic effects of SGLT2 inhibitors have been proposed. Mechanisms also include regulation of inflammatory and oxidative pathways along with improved endothelial function. Recent multicentre studies of SGLT2 inhibitors have shown that they reduce hospitalisations for heart failure after their use, regardless of type 2 diabetes and the degree of cardiac systolic dysfunction

Keywords:

Inhibitors SGLT2, Heart failure, Cardiology

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Kaźmierski, W., Jurek, J., Lis, P., Lis, A., Ziobro, A., Ziomek, M., … Kocur, K. (2024). Sodium-glucose cotransporter2 inhibitors in heart failure. Prospects in Pharmaceutical Sciences, 22(3), 225–232. https://doi.org/10.56782/pps.240

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Wojciech Kaźmierski

wkazmierski97@gmail.com

Affiliation:

a:1:{s:5:"en_US";s:108:"Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705, Krakow, Poland.";} Poland

Jakub Jurek

Affiliation:

Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705, Krakow, Poland Poland

Paulina Lis

Affiliation:

Leszek Giec Upper-Silesian Medical Centre of the Medical University of Silesia in Katowice, 40-635 Katowice, Poland Poland

Anna Lis

Affiliation:

Leszek Giec Upper-Silesian Medical Centre of the Medical University of Silesia in Katowice, 40-635 Katowice, Poland Poland

Anna Ziobro

Affiliation:

District Hospital in Zakopane, 34-500, Zakopane, Poland Poland

Mateusz Ziomek

Affiliation:

Military Institute of Medicine - National Research Institute, 04-141, Warsaw, Poland Poland

Katarzyna Camlet

Affiliation:

District Hospital in Zakopane, 34-500, Zakopane, Poland Poland

Kinga Kocur

Affiliation:

District Hospital in Oświęcim, 32-600, Oświęcim, Poland Poland

Sodium-glucose cotransporter2 inhibitors in heart failure

Wojciech Kaźmierski

Jakub Jurek

Paulina Lis

Anna Lis

Anna Ziobro

Mateusz Ziomek

Katarzyna Camlet

Kinga Kocur

Abstract

Keywords:

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