Immunoactivities of fractions of Elephantopus scaber linn leaf in NK cells, CD8+ T cells, and perforin

Mega Yulia; Yufri Aldi; Hansen Nasif; Fatma Sri Wahyuni; Dachriyanus

doi:10.56782/pps.304

Published : 2025-02-17

Vol. 23 No. 1 (2025)

Immunoactivities of fractions of Elephantopus scaber linn leaf in NK cells, CD8+ T cells, and perforin

Mega Yulia

Yufri Aldi

Hansen Nasif

Fatma Sri Wahyuni

Dachriyanus

DOI: https://doi.org/10.56782/pps.304

Abstract

The goal of this study is to determine the effect of a fraction of Elephantopus scaber Linn leaf extract on NK cells, CD8⁺ T cells, and perforin in male white mice using one dose of Elephantopus scaber Linn fraction at 30 mg/kg BW. In this study, 25 experimental animals were divided into 5 groups there are negative control, positive control, and 3 fractions of Elephantopus scaber Linn leaf, namely n-hexane, ethyl acetate, and butanol. Mice were treated with Elephantopus scaber Linn leaf fraction for 7 days after being previously stimulated by the SARS-Cov-2 virus antigen (inavac^®). The animals were then analyzed on day 8. Duncan analysis was performed after One-Way ANOVA was used to evaluate the data. The test results showed that the concentration of NK cells increased slightly although it did not significantly increase (**p < 0.01; *p < 0.05) and the concentration of CD8⁺ T cells and perforin significantly decreased (**p < 0.01; *p < 0.05). It is concluded that a fraction of Elephantopus scaber Linn leaf shows immunomodulatory activity.

Keywords:

Elephantopus scaber Linn, immunoactivities, fraction, NK cells, CD8+ T cells, Perforin

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Yulia, M., Aldi, Y., Nasif, H., Sri Wahyuni, F., & Dachriyanus. (2025). Immunoactivities of fractions of Elephantopus scaber linn leaf in NK cells, CD8+ T cells, and perforin. Prospects in Pharmaceutical Sciences, 23(1), 53–59. https://doi.org/10.56782/pps.304

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