Drugs and chemical substances inducing diabetes - review of the literature

Paulina Oleksa; Daria Żuraw; Kacper Jasiński; Mateusz Sobczyk; Mikołaj Porzak; Alicja Sodolska; Karolina  Haczkur-Pawłowska

doi:10.56782/pps.183

Published : 2024-05-06

Vol. 22 No. 2 (2024)

Drugs and other chemical substances inducing diabetes – review of the literature

Paulina Oleksa

Daria Żuraw

Kacper Jasiński

Mateusz Sobczyk

Mikołaj Porzak

Alicja Sodolska

Karolina Haczkur-Pawłowska

DOI: https://doi.org/10.56782/pps.183

Abstract

A Type 3 diabetes, classified as secondary diabetes, includes drug-induced or chemical-induced forms of diabetes. We distinguish many types of drugs that can induce diabetes, among others commonly used glucocorticosteroids, β-blockers and diuretics, antidepressants and antipsychotics, statins, or antiviral drugs.

We aimed to evaluate the impact of chosen drugs and other chemical substances on glycemic control, to analyse the mechanisms of development of drug-induced diabetes and to propose the therapeutic procedures. We conducted the literature review using the Pubmed and Google Scholar. We analysed reviews, systematic reviews, meta-analysis, randomized controlled trials, clinical trials, and observational studies published from 2013 to 2024.

Mechanisms of diabetes development are various and complex. However, we need to underline the role of drug-induced weight gain. The duration of therapy is also important because longer therapy is usually associated with higher risk of development of diabetes.

Drug-induced diabetes is a significant clinical problem. The benefits of using the drug often outweigh the side effects associated with poor glycemic control. Currently, pharmacotherapy of drug-induced diabetes is similar to the standards of treatment for other types of diabetes. Changing therapy to the drug with lower metabolic risk should be considered as far as possible. Moreover, due to common presence of pesticides, heavy metals and endocrine-disrupting chemicals, inducing diabetes is also very problematic and constitutes an important area of new scientific researches.

Keywords:

type 3 diabetes, secondary diabetes, drug-induced diabetes, drug-induced hyperglycemia, insulin resistance

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Oleksa, P., Żuraw, D., Jasiński, K., Sobczyk, M., Porzak, M., Sodolska, A., & Haczkur-Pawłowska, K. (2024). Drugs and other chemical substances inducing diabetes – review of the literature. Prospects in Pharmaceutical Sciences, 22(2), 7–17. https://doi.org/10.56782/pps.183

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Paulina Oleksa

gp.oleksa@gmail.com

Affiliation:

a:1:{s:5:"en_US";s:52:"Independent Public Clinical Hospital No. 4 in Lublin";} Poland

Daria Żuraw

Affiliation:

Central Clinical Hospital, University Clinical Center of Warsaw Medical University, ul. Banacha 1A, 02-097 Warsaw, Poland Poland

Kacper Jasiński

Affiliation:

Stefan Kardynał Wyszyński Regional Specialist Hospital in Lublin, Aleja Kraśnicka 100, 20-718 Lublin, Poland Poland

Mateusz Sobczyk

Affiliation:

Stefan Kardynał Wyszyński Regional Specialist Hospital in Lublin, Aleja Kraśnicka 100, 20-718 Lublin, Poland Poland

Mikołaj Porzak

Affiliation:

Stefan Kardynał Wyszyński Regional Specialist Hospital in Lublin, Aleja Kraśnicka 100, 20-718 Lublin, Poland Poland

Alicja Sodolska

Affiliation:

Lubimed- Family Medical Center in Lublin, ul. Jacka Woronieckiego 11, 20-492, Lublin, Poland Poland

Karolina Haczkur-Pawłowska

Affiliation:

Independent Public Clinical Hospital No. 4 in Lublin, ul. Doktora Kazimierza Jaczewskiego 8, 20-954 Lublin, Poland Poland

Drugs and other chemical substances inducing diabetes – review of the literature

Paulina Oleksa

Daria Żuraw

Kacper Jasiński

Mateusz Sobczyk

Mikołaj Porzak

Alicja Sodolska

Karolina Haczkur-Pawłowska

Abstract

Keywords:

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