Nanostructured lipid carriers applications in cosmeceuticals: structure, formulation, safety profile and market trends

Wishah Nadeem; Sadaf Ahmad; Muneeb Ur Rahman; Habiba Akram; Usman Abdullah

doi:10.56782/pps.315

Published : 2025-06-04

Vol. 23 No. 2 (2025)

Nanostructured lipid carriers applications in cosmeceuticals: structure, formulation, safety profile and market trends

Wishah Nadeem

Sadaf Ahmad

Muneeb Ur Rahman

Habiba Akram

Usman Abdullah

DOI: https://doi.org/10.56782/pps.315

Abstract

Cosmeceuticals, a combination of medicines and cosmetics, provide therapeutic advantages using advanced drug delivery mechanisms. The products improve not only skin health but also beauty. Most of the cosmeceuticals used transdermal delivery systems, which have limitations in absorption and penetration. Advanced drug delivery systems, such as nanostructured lipid carriers (NLCs), have great potential in avoiding the epidermal barrier toward enhanced delivery and targeted distribution of active ingredients. Nanostructured Lipid Carriers are formed by mixing spatially incompatible long and short-chain lipids using various formulation techniques. Nanostructured lipid carriers can efficiently encapsulate active ingredients and ensure controlled release and targeted action. These benefits, combined with the properties of the encapsulated substances, contribute to improved skin hydration, moisturization, and anti-ageing effects when applied in cosmeceuticals. NLCs have shown potential in hair care, sunscreens, and UV protection applications because they enhance the delivery and stability of active ingredients. Despite these benefits, detailed information on the potential limitations of NLC systems remains underreported. Current research emphasizes the importance of conducting thorough in vitro toxicity studies per the Organization for Economic Co-operation and Development recommendations to assess their safety profiles and identify possible concerns. More research is also essential to close knowledge gaps and guarantee that the safety and effectiveness of NLC formulations are fully proven before moving on with clinical trials or regulatory evaluations.

Keywords:

Nanostructured Lipid Carriers, Cosmeceuticals, Transdermal Drug Delivery Systems, Skin Care, Hair Care

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Nadeem, W., Ahmad, S., Ur Rahman, M., Akram, H., & Abdullah, U. (2025). Nanostructured lipid carriers applications in cosmeceuticals: structure, formulation, safety profile and market trends. Prospects in Pharmaceutical Sciences, 23(2), 74–83. https://doi.org/10.56782/pps.315

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Wishah Nadeem

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University of Sargodha Pakistan

Sadaf Ahmad

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University of Sargodha Pakistan

Muneeb Ur Rahman

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a:1:{s:5:"en_US";s:22:"University of Sargodha";} Pakistan

Habiba Akram

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Department of Pharmacy, University of Agriculture, Faisalabad 38000, Pakistan Pakistan

Usman Abdullah

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College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan Pakistan