Advanced invasomal delivery system for enhanced topical application of bifonazole in fungal infections

Shivaji Patil; Sushil Bhargav

doi:10.56782/pps.317

Published : 2025-03-01

Vol. 23 No. 1 (2025)

Advanced invasomal delivery system for enhanced topical application of bifonazole in fungal infections

Shivaji Patil

Sushil Bhargav

DOI: https://doi.org/10.56782/pps.317

Abstract

The design and development of invasomes containing bifonazole for effective topical fungal treatment was investigated to improve the bioavailability and therapeutic efficacy of this antifungal agent. Invasomes, novel lipid-based vesicular systems, were formulated to enhance skin penetration and provide sustained drug release, thereby increasing the local concentration of bifonazole at the site of infection. The formulation was optimized using response surface methodology (RSM), where various factors such as phosphatidylcholine, terpenes, and ethanol were varied to evaluate their effects on entrapment efficiency, vesicle size, and drug release characteristics. The optimized invasomal formulation demonstrated high entrapment efficiency (~74.12%) and an average vesicle size of 154.45 nm, suitable for effective skin penetration. In vitro release studies revealed sustained drug release from the invasomes, with a slower release profile compared to the plain drug. The optimized formulation exhibited enhanced antifungal activity, suggesting that invasomes could serve as a promising carrier for the topical delivery of bifonazole, offering a potential solution for treating superficial fungal infections with improved efficacy and patient compliance.

Keywords:

Invasomes, Bifonazole, Drug Encapsulation, Skin Penetration, Response Surface Methodology

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Patil, S., & Bhargav, S. (2025). Advanced invasomal delivery system for enhanced topical application of bifonazole in fungal infections. Prospects in Pharmaceutical Sciences, 23(1), 102–110. https://doi.org/10.56782/pps.317

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Shivaji Patil

shivajipatildocument1993@gmail.com

Affiliation:

Department of pharmaceutical sciences, Madhav University, Abu Road Pindwara, Dist Sirohi -307026, Rajasthan India

Sushil Bhargav

dean.pharmacy@madhavuniversity.edu.in

Affiliation:

Department of pharmaceutical sciences, Madhav University, Abu Road Pindwara, Dist Sirohi -307026, Rajasthan India