A NOVEL TARGETED FORMULATION FOR OSTEOARTHRITIS: EXPLORING SYNERGISTIC BENEFITS OF CISSUS QUADRANGULARIS, BOSWELLIA SERRATA, PROPOLIS AND PALMITOYLETHANOLAMIDE: EXPLORING SYNERGISTIC BENEFITS OF CISSUS QUADRANGULARIS, BOSWELLIA SERRATA, PROPOLIS AND PALMITOYLETHANOLAMIDE

DHARANI B; SUBA A

doi:10.56782/pps.479

Published : 2025-10-01

No. 2025 (Early Access)

A NOVEL TARGETED FORMULATION FOR OSTEOARTHRITIS: EXPLORING SYNERGISTIC BENEFITS OF CISSUS QUADRANGULARIS, BOSWELLIA SERRATA, PROPOLIS AND PALMITOYLETHANOLAMIDE

DHARANI B

SUBA A

DOI: https://doi.org/10.56782/pps.479

EXPLORING SYNERGISTIC BENEFITS OF CISSUS QUADRANGULARIS, BOSWELLIA SERRATA, PROPOLIS AND PALMITOYLETHANOLAMIDE

Abstract

Osteoarthritis (OA) is known as a debilitating form of arthritis that is marked by progressive degradation of cartilage, synovial inflammation, chronic pain and subchondral bone remodelling. OA causes progressive stiffness and decreased mobility, significantly affecting the overall quality of life of the person affected. In spite of vast research in this area, the present pharmacological interventions are purely symptomatic. Consequently, there is an expanding interest in exploring multi-dimensional targeting of pathophysiological pathways using natural treatment options, while improving patient compliance by enhancing the safety profile. The current review focusses on a novel, innovative and conceptual formulation that is designed by the authors with the scientific-evidence packed natural compounds for management of OA. This review targets to evaluate the rationale behind formulating a conceptual novel tablet consisting of Cissus quadrangularis, Boswellia serrata, Propolis and Palmitoylethanolamide (PEA) for definitive management of OA. To our knowledge, this is the first article to explore this combination. It is designed in such a way that it targets oxidative stress, inflammation, cartilage destruction and pain in OA simultaneously in a synergistic manner. In contrast to conventional treatment options which primarily provide symptom relief, this novel conceptual formulation could offer analgesic, chondroprotective and regenerative effects with reasonable safety profile making it suitable for long-term use. This formulation has a potential to emerge as an effective and safer alternatives for treatment of OA, by helping to bridge the gap between integrative and conventional medicine.

Keywords:

Propolis, Boswellia, Palmitoylethanolamide,, Drug Formulation, Cissus, osteoarthritis

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B, D., & A, S. (2025). A NOVEL TARGETED FORMULATION FOR OSTEOARTHRITIS: EXPLORING SYNERGISTIC BENEFITS OF CISSUS QUADRANGULARIS, BOSWELLIA SERRATA, PROPOLIS AND PALMITOYLETHANOLAMIDE: EXPLORING SYNERGISTIC BENEFITS OF CISSUS QUADRANGULARIS, BOSWELLIA SERRATA, PROPOLIS AND PALMITOYLETHANOLAMIDE. Prospects in Pharmaceutical Sciences, (2025 (Early Access). https://doi.org/10.56782/pps.479

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