Comprehensive review of topical phytoformulations and pharmacological activities for the treatment of wrinkles

Arun Kumar; Mayur Porwal; Vaibhav Rastogi

doi:10.56782/pps.503

Published : 2025-12-31

Vol. 23 No. 4 (2025)

Comprehensive review of topical phytoformulations and pharmacological activities for the treatment of wrinkles

Arun Kumar

DR. Mayur Porwal

DR. Vaibhav Rastogi

DOI: https://doi.org/10.56782/pps.503

Abstract

The rising demand for natural cosmeceuticals is primarily attributed to their minimal side effects and their potential as alternatives to synthetic drugs. Numerous plant-derived compounds have been identified with properties beneficial for skin care, including whitening, anti-aging, and anti-wrinkle effects, as shown in the graphical abstract. This review comprehensively evaluates the efficacy of various herbal remedies for wrinkle treatment, drawing evidence from clinical studies, experimental research, and traditional practices. The study is aimed to identify medicinal plants with substantial scientific support for their therapeutic benefits, particularly in wrinkle reduction. An extensive literature search was conducted using databases such as PubMed, Google Scholar, Scopus, Web of Science, and ScienceDirect. The Plant List database was also consulted to confirm the scientific names, plant families, traditional uses, and active constituents of each plant. The analysis revealed 23 plant species from 19 different families that are traditionally used for managing symptoms of premature aging, including wrinkles and pimples. These plants were reviewed for their mechanisms of action, bioactive constituents, availability, and potential applications in cosmetic formulations. Scientific studies have confirmed that phytoconstituents possess anti-inflammatory, photoprotective, and anti-wrinkle properties, with proven inhibitory effects on wrinkle-related enzymes such as elastase and collagenase. Key botanicals such as Diospyros kaki, Ipomoea carnea, Calendula officinalis, Ocimum basilicum, and Moringa oleifera have shown significant cosmeceutical potential. Overall, the findings suggest that phytoconstituents from medicinal plants represent promising and potentially superior alternatives to synthetic agents for the development of effective anti-wrinkle treatments.

Keywords:

Anti-wrinkles, pharmacological activity, Traditional plants, collagen, elastin

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Kumar, A., Porwal, M., & Rastogi, V. (2025). Comprehensive review of topical phytoformulations and pharmacological activities for the treatment of wrinkles. Prospects in Pharmaceutical Sciences, 23(4), 186–204. https://doi.org/10.56782/pps.503

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Arun Kumar

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a:1:{s:5:"en_US";s:114:"Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad-244001, Uttar Pradesh, India.";} India

DR. Mayur Porwal

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Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad-244001, Uttar Pradesh, India. India

DR. Vaibhav Rastogi

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Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad-244001, Uttar Pradesh, India. India