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BREAST CANCER DISEASE AND NEW COMPOUNDS WITH ANTICANCER ACTIVITY
Paweł Żero
Maria Niemyjska
Magdalena Rasztawicka
Dorota Maciejewska
Abstract
Breast cancer is the most common women’s malignant tumour. Many drugs used in chemotherapy are hazardous because of side-effects, therefore, the search for new active compounds is advisable. 3,3’-diindolilomethane (DIM) is known to inhibit DNA synthesis and cell proliferation in human breast cancer cells. It is a natural product produced during the autolytic breakdown of glucobrassicin, that occurs in Crucifereae (cabbage, Brussels sprouts, cauliflower). At present, in the Department of Organic Chemistry derivates of DIM are synthesised, which could be considered as potential chemotherapeutics.
Keywords:
tumour, breast cancer, chemical therapy, 3,3’-diindolylmethaneMost read articles by the same author(s)
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