STAPHYLOCOCCAL RESISTANCE TO ANTIBACTERIAL AGENTS
DOI:
https://doi.org/10.56782/pps.42Keywords:
antibiotics, bacterial resistance, plasmids, S. aureusAbstract
Increase of the resistance of S. aureus and other bacteria to antibiotics and remaining antimicrobial agents is an essential problem in medicine. The knowledge of the resistance mechanism and their genetic basis enables the search for new agents (drugs, disinfectants), acting against staphylococci, including multidrug resistance strains, responsible for nosocomial infections.
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References
CDC. Staphylococcus aureus resistant to vancomycin - United States, 2002. MMWR, 2002, 51 (26), 565-567
CDC. Staphylococcus aureus with reduced susceptibility to vancomycin - United States, 1997. MMWR, 1997, 46 (33), 765
Chien J. W., Kucia M. L., Salata R. A. 2000. Use of linezolid, an oxazolidone, in the treatment of multidrug-resistant gram-positive bacterial infections. Clin. Infect. Diseases. 30: 146-151 DOI: https://doi.org/10.1086/313597
De Lencastre H., de Jonge B. L., Matthews P. R., Tomasz A. 1994. Molecular aspects of methicillin resistance in Staphylococcus aureus. J. Antimicrob. Chemother. 33: 7-24 DOI: https://doi.org/10.1093/jac/33.1.7
Dzierżanowska D. Antybiotykoterapia w zakażeniach szpitalnych. W: Zakażenia szpitalne. Red. Dzierżanowska D. Jeljaszewicz J. Alfa-Medica Press 1999. 517-534
Dzierżanowska D., Murawska B. 1998. Rola metycylinoopornych gronkowców (MRSA) w zakażeniach szpitalnych. Terapia 9: 16-19
Firth N., Skurray R. A. 1998. Mobile elements in the evolution and spread of multiple-drug resistance in staphylococci. Drug Resistance Updates. 1: 49-58 DOI: https://doi.org/10.1016/S1368-7646(98)80214-8
Foster T. J. 1983. Plasmid-determined resistance to antimicrobial drugs and toxic metal ions in bacteria. Microbiol. Rev. 47:361-409 DOI: https://doi.org/10.1128/mr.47.3.361-409.1983
Gillespie M. T., May W., Skurray R. A. 1986. Plasmid-encoded resistance to acriflavine and qarternary ammonium compounds in methicillin-resistant Staphylococcus aureus. FEMS Microbiol. Lett. 34: 47-51 DOI: https://doi.org/10.1111/j.1574-6968.1986.tb01346.x
Hiramatsu K., Hanaki H., Ino T., Tabuta T., Oguri T., Tenover F. C. 1997. Methicillin Resistant Staphylococcus aureus clinical strains with reduced vancomycin susceptibility. J. Antimicrob. Chemother. 40, 135-146 DOI: https://doi.org/10.1093/jac/40.1.135
Hsieh P-Ch., Siegel S. A., Rogers B., Davis D., Lewis K. 1998. Bacteria lacking a multidrug pump: a sensitive tool for drug discovery. Proc. Natl. Acad. Sci. USA. 95: 6602-6606 DOI: https://doi.org/10.1073/pnas.95.12.6602
Kaatz G. W., Seo S. M., O'Brien L., Wahiduzzaman M., Foster T. J. 2000. Evidence for the existence of a multidrug efflux transporter distinct from NorA in Staphylococcus aureus. Antimicrob. Agents Chemother. 45: 1404-1406 DOI: https://doi.org/10.1128/AAC.44.5.1404-1406.2000
Kaatz G. W., Seo S. M., Ruble Ch.A. 1993. Efflux-mediated fluorochinolone resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 37: 1086-1094 DOI: https://doi.org/10.1128/AAC.37.5.1086
Kazama H., Hamashima H., Sasatsu M., Arai T. 1998. Distribution of the antiseptic-resistance gene qacED 1 in Gram-positive bacteria. FEMS Microbiol. Lett. 165: 295-299 DOI: https://doi.org/10.1111/j.1574-6968.1998.tb13160.x
Levy S. B. 1992. Active efflux mechanisms for antimicrobial resistance. Antimicrob. Agents Chemother. 36: 695-703 DOI: https://doi.org/10.1128/AAC.36.4.695
Linares J. 2001. The VISA/GISA problem:therapeutic implications. Clin. Microbiol. Infect. 7 Suppl. 4: 8-15 DOI: https://doi.org/10.1046/j.1469-0691.2001.00054.x
Littlejohn T. G., Rouch D. A., Cram D. S., Di Bernardino D., Skurray A. Molecular and sequence analysis of qacA specifying antiseptic/disinfectant resistance in staphylococci. W: Molecular Biology of the Staphylococci, eds. R.P. Novick. VCH Publishers Inc. 1990, New York, 175-180
Littlejohn T. G., Paulsen I. T., Gillepsie M. T., Tennet J. M., Midgley M., Jones I. G., Purewal A. S., Skurray R. A. 1992. Substrate specificity and energetics of antiseptic and disinfectant resistance in Staphylococcus aureus. FEMS Microbiol. Lett. 95: 259-266 DOI: https://doi.org/10.1111/j.1574-6968.1992.tb05376.x
Livermore D. M. 1995. b -lactamases in laboratory and clinical resistance. Clin. Microbiol. Rev. 8: 557-584 DOI: https://doi.org/10.1128/CMR.8.4.557
Lyon B. R., Skurray R. A. 1987. Antimicrobial resistance of Staphylococcus aureus: genetic basis. Microbiol. Rev. 51: 88-134 DOI: https://doi.org/10.1128/mr.51.1.88-134.1987
Łęski T., Hryniewicz W. 1999. Mupirocyna - natura chemiczna oraz jej zastosowanie w leczeniu zakażeń bakteryjnych. Nowa Klinika. 6: 533-536
McDonnel G., Russell A. D. 1999. Antiseptics and disinfectants: activity, action and resistance. Clin. Microbiol. Rev. 12: 147-179 DOI: https://doi.org/10.1128/CMR.12.1.147
McManus J. 1999. Vancomycin resistant staphylococcus reported in Hong Kong. BMJ, 318, 626 DOI: https://doi.org/10.1136/bmj.318.7184.626
Młynarczyk A., Młynarczyk G., Jeljaszewicz J. 1999. Charakterystyka plazmidów penicylinazowych u szczepów Staphylococcus aureus. Med. Dośw. Mikrobiol. 51: 1-8
Młynarczyk A. Mechanizmy oporności na makrolidy, streptograminy i linkozamidy. Polskie Towarzystwo Farmaceutyczne, Oddział Warszawski, 11 grudzień 2001.
Murray P. R., Rosenthal K. S., Kobayashi G. S., Pfaller M. A. 1998. Medical Microbiology 3rd Edition, 160-168, 175-188
Neyfakh A. A. 1997. Natural functions of bacterial multidrug transporters. Trends Microbiol. 5: 309-313 DOI: https://doi.org/10.1016/S0966-842X(97)01064-0
Neyfakh A. A. 1992. The multidrug efflux transporter of Bacillus subtilis is a structural and functional homolog of the Staphylococcus NorA protein. Antimicrob. Agents Chemother. 36: 484-485 DOI: https://doi.org/10.1128/AAC.36.2.484
Nikaido H. 1996. Multidrug efflux pumps of Gram-negative bacteria. J. Bacteriol. 178: 5853-5859 DOI: https://doi.org/10.1128/jb.178.20.5853-5859.1996
Nikaido H. 1998. Multiple antibiotic resistance and efflux. Curr. Opinion Microbiol. 1: 516-523 DOI: https://doi.org/10.1016/S1369-5274(98)80083-0
Noble W. C., Viarani Z., Cree R. 1992. Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus. FEMS Microbiol. Lett. 93, 195-198 DOI: https://doi.org/10.1111/j.1574-6968.1992.tb05089.x
Noguchi N., Hase M., Kitta M., Sasatsu M., Deguchi K., Kono M. 1999. Antiseptic susceptibility and distribution of antiseptic-resistance genes in methicillin-resistant Staphylococcus aureus. FEMS Microbiol. Lett. 172: 247-253 DOI: https://doi.org/10.1111/j.1574-6968.1999.tb13475.x
Novick R.P. 1990. The Staphylococcus as a molecular genetic system. W: Molecular biology of the staphylococci Red. P. Novick, R. A. Skurray. VCH Publishers, Inc. New York, 1-37
Otto M., Gotz F. 2001. ABC transporters of staphylococci. Res. Microbiol. 152 (3-4): 351-6 DOI: https://doi.org/10.1016/S0923-2508(01)01206-2
Pao S. S., Paulsen I. T., Saier M. H. Jr. 1998. Major facilitator superfamily. Microbiol Mol. Biol. Rev. 62: 1-34 DOI: https://doi.org/10.1128/MMBR.62.1.1-34.1998
Paulsen I. T., Brown M. H., Littlejohn T. G., Mitchell B. A., Skurray R. A. 1996. Multidrug resistance proteins QacA and QacB from Staphylococcus aureus; Membrane topology and identification of residues involved in substrate specificity. Proc. Natl. Acad. Sci. USA. 93: 3630-3635 DOI: https://doi.org/10.1073/pnas.93.8.3630
Paulsen I. T., Firth N., Skurray R. A. 1997. Resistance to antimicrobial agents other than b -lactams. W: The Staphylococci in human disease. Red. K. B. Crossley, G. L. Archer. Churchill Livington, New York. 175-212
Paulsen I. T., Brown M. H., Skurray R. A. 1996. Proton-dependent multidrug efflux systems. Microbiol Rev. 60: 575-608 DOI: https://doi.org/10.1128/mr.60.4.575-608.1996
Paulsen I. T., Skurray R. A., Tam R., Saier M. H. Jr, Turner R. J., Weiner J. H., Goldberg E. B., Grinius L. L. 1996. The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs. Mol. Microbiol. 19: 1167-1175 DOI: https://doi.org/10.1111/j.1365-2958.1996.tb02462.x
Ramsey M. A., Bradley S. F., Kauffman C. A., Morton T. M. 1996. Identification of chromosomal location of mupA gene, encoding lowlewel mupirocin resistance in staphylococcal isolates. Antimicrob. Agents Chemother. 40 (12): 2820-2823 DOI: https://doi.org/10.1128/AAC.40.12.2820
Reverdy M. -E., Bes M., Brun Y., Fleurette J. 1992. Activity of four antiseptics (acriflavine, benzalconium chloride, chlorhexidine digluconate, hexamidine di-isethonate) and of ethidium bromide on 392 strains representing 26 Staphylococcus species. Med. Microbiol. Lett. 1: 56-63.
Reynolds P. E., Fuller C. 1986. Methicillin-resistant strains of Staphylococcusaureus; presence of identical additional penicillin-binding protein in all strains examined. FEMS Microbiol. Lett. 33: 251-254 DOI: https://doi.org/10.1111/j.1574-6968.1986.tb01281.x
Robinson J. B., Tuovinen O. H. 1984. Mechanisms of microbial resistance and detoxification of mercury and organomercury compounds: physiological, biochemical and genetic analyses. Microbiol. Rev. 48: 95-124 DOI: https://doi.org/10.1128/mr.48.2.95-124.1984
Ross J. I., Esdy E. A., Cove J. H., Baumberg S. 1995. Identification of a chromosomaly encoded ABC-transport system with which the staphylococcal erythromycin exporter MsrA may interact. Gene. 153: 93-98 DOI: https://doi.org/10.1016/0378-1119(94)00833-E
Russell A. D., Maillard J. -Y., Furr J.R. 1998. Possible link between bacterial resistance and use of antibiotics and biocides. Antimicrob. Agents Chemother. 42: 2151 DOI: https://doi.org/10.1128/AAC.42.8.2151
Rybak J. M., Hershberger E., Moldovan T., Grucz R. G. 2000. In vitro activities of daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin against staphylococci and enterococci, including vancomycin-intermediate and -resistant strains. Antimicrob. Agents Chemother. 44: 1062-1066 DOI: https://doi.org/10.1128/AAC.44.4.1062-1066.2000
Sasatsu M., Shibata Y., Noguchi N., Kono M. 1992. High-level resistance to ethidium bromide and antiseptics in Staphylococcus aureus. FEMS Microbiol. Lett. 93: 109-114 DOI: https://doi.org/10.1111/j.1574-6968.1992.tb05075.x
Shaw K. J., Rather P. N., Hare R. S., Miller G. H. 1993. Molecular genetics of aminoglycoside resistance genes and familial relationship of the aminoglycoside-modifying enzymes. Microbiol. Rev. 57: 138-163 DOI: https://doi.org/10.1128/mr.57.1.138-163.1993
Stefańska J. 2000. Występowanie i rozprzestrzenianie się u Staphylococcus aureus determinant oporności na antybiotyki oraz inne związki o aktywności przeciwbakteryjnej. Zakład Mikrobiologii Farmaceutycznej AM w Warszawie. Rozprawa doktorska
Stefańska J., Młynarczyk G., Młynarczyk A., Starościak B., Łuczak M. 2002. Oporność szczepów Staphylococcus aureus na czwartorzędowe sole amoniowe i chlorheksydynę. Med. Dośw. Mikrobiol. 54, 191-197
Suresh J. A. Bitter K., Moreland. T., Raudales F., Diaz-Luna H. 1999. Methicillin resistant Staphylococcus aureus infection in a renal recipient treated successfully with a novel new antimicrobial agent (linezolid): new treatment opinions for infections due to resistant organisms. Clin. Infect. Dis. 29: 1341-1342 DOI: https://doi.org/10.1086/313492
Tanaka M., Sato K., Kimura Y., Hayakawa I. 1991. Inhibition by quinolones of DNA gyrase from Staphylococcus aureus. Antimicrob. Agents Chemother. 35: 1489-1491 DOI: https://doi.org/10.1128/AAC.35.7.1489
Tennet J. M., Lyon B. R., Midgley M., Jones J. G., Purewal A. S., Skurray R. A. 1989 Physical and chemical characterisation of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus. J. Gen. Microbiol. 135: 1-10 DOI: https://doi.org/10.1099/00221287-135-1-1
Tracolsomboon S., Danchaivijitr S, Rongrungruang Y., Dhiraputra C., Susaemgrat W., Ito T., Hiramatsu K. 2001. First report of methicillin-resistant Staphylococcus aureus with reduced susceptibility to vancomycin in Thailand. JMC, 39, 591-595 DOI: https://doi.org/10.1128/JCM.39.2.591-595.2001
Yamamoto T., Tamura Y., Yokota T. 1988. Antiseptic and antibiotic resistance plasmid in Staphylococcus aureus that possesses ability to confer chlorhexidine and acrinol resistance. Antimicrob. Agents Chemother. 32: 932-93 DOI: https://doi.org/10.1128/AAC.32.6.932
Zarrouk V., Bozdogan B., Leclercq R., Garry L., Carbon C., Fantin B. 2000. Influence of resistance to streptogramin A type antibiotics on the activity of quinupristin-dalfopristin in vitro and experimental endocarditis due to Staphylococcus aureus. Antimicrob. Agents Chemother. 44: 1168-1173 DOI: https://doi.org/10.1128/AAC.44.5.1168-1173.2000
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