PHARMACEUTICALS IN THE ENVIRONMENT. I: EVALUATION OF TOXICITY OF THREE FLUOROQUINOLONES TO DUCKWEED LEMNA MINOR

Authors

  • Magdalena Bielińska Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny Zakład Badania Środowiska,
  • Grzegorz Nałęcz-Jawecki Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny Zakład Badania Środowiska,

DOI:

https://doi.org/10.56782/pps.64

Keywords:

fluoroquinolones, ecotoxicology, duckweed, drugs in the environment

Abstract

Drugs used in human and veterinary medicine belong to a new class of environmental pollutants. Antibiotics and chemotherapeutics may produce biological effects at very low concentrations. Moreover, the continuous exposure of bacteria to even small concentrations of antibiotics or active metabolites could lead to the emergence of resistant bacteria strains. Antibiotics also may have high biological activity against non-target organisms as plants. In case of duckweed (Lemna minor) the EC20 values for fluoroquinolones as ciprofloxacin, ofloxacin and lomefloxacin are 64, 100 and 370 μg/l, respectively.

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References

Ball P. (2000). Quinolone generations: natural history or natural selection? J Antimicrob Chemotherapy 46: 17-24. DOI: https://doi.org/10.1093/oxfordjournals.jac.a020889

Brain R.A., Johnson D.J., Richards S.M., Sanderson H., Sibley P.K., Solomon K.R. (2004). Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static-reneval test. Environ Toxicol Chem. 23: 371-382. DOI: https://doi.org/10.1897/02-576

Breton R., Boxall A. (2003). Pharmaceuticals and personal care products in the environment: Regulatory drivers and research needs. QSAR & Combinatorial Sci. 22: 399-409. DOI: https://doi.org/10.1002/qsar.200390030

Cleuvers M. (2003). Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett. 142: 185-194. DOI: https://doi.org/10.1016/S0378-4274(03)00068-7

Daughton C.G., Ternes T.A. (1999). Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Prospect. 107: 907-938. DOI: https://doi.org/10.1289/ehp.99107s6907

Duong H.A., Pham N.H., Nguyen H.T., Hoang T.T., Pham H.V., Pham V.C., Berg M., Giger W., Alder A.C. (2008). Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam. Chemosphere 72: 968-973. DOI: https://doi.org/10.1016/j.chemosphere.2008.03.009

Fent K., Weston A.A., Caminada D. (2006). Ecotoxicology of human pharmaceuticals. Aquat Toxicol. 76: 122-159. DOI: https://doi.org/10.1016/j.aquatox.2005.09.009

Golet E.M., Xifra I., Siegrist H., Alder A.C., Giger W. (2003). Enviornmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil. Enviorn Sci Technol. 37: 3243-3249. DOI: https://doi.org/10.1021/es0264448

Hirsch R., Ternes T., Haberer K., Kratz K-L. (1999). Occurrence of antibiotics in the aquatic environment. Sci Total Environ. 225: 109-118. DOI: https://doi.org/10.1016/S0048-9697(98)00337-4

ISO 8692. (1993). Water Quality – Algal Growth Inhibition Test. International Organisation for Standardisation.

ISO DIS 20079. Water Quality - Determination of the Toxic Effect of Water Constituents and Waste Water to Duckweed (Lemna minor) - Duckweed Growth Inhibition Test. International Organisation for Standardisation.

Kümmerer K. (2001). Drugs in the environment: emission of drugs, diagnostic aids and didinfectants into wastewater by hospitals in relation to other sources – a review. Chemosphere 45: 957-969. DOI: https://doi.org/10.1016/S0045-6535(01)00144-8

Mohan B.S., Hosetti B.B. (1999). Aquatic Plants for Toxicity Assessment. Environ Res Section A. 81: 259-274. DOI: https://doi.org/10.1006/enrs.1999.3960

OECD 201. (2006). Freshwater Alga and Cyanobacteria, Growth Inhibition Test. Guideline for the testing of chemicals. OECD. Organisation for Economic Co-operation and Development, Paris.

OECD 221. (2006). Lemna sp. Growth Inhibition Test. Guideline for the testing of chemicals. OECD. Organisation for Economic Co-operation and Development, Paris.

Picó Y., Andreu V. (2007). Fluoroquinolones in soil: risks and challenges. Anal Bioanal Chem. 387: 1287-1299. DOI: https://doi.org/10.1007/s00216-006-0843-1

Robinson A.A., Belden J.B., Lydy M.J. (2005). Toxicity of fluoroquinolone antibiotics to aquatic organisms. Environ Toxicol Chem. 24: 423-430. DOI: https://doi.org/10.1897/04-210R.1

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Published

2009-09-17

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How to Cite

PHARMACEUTICALS IN THE ENVIRONMENT. I: EVALUATION OF TOXICITY OF THREE FLUOROQUINOLONES TO DUCKWEED LEMNA MINOR. (2009). Prospects in Pharmaceutical Sciences, 7(4), 24-30. https://doi.org/10.56782/pps.64

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