ZANIECZYSZCZENIE ŚRODOWISKA PRZYRODNICZEGO LEKAMI.  I: OCENA TOKSYCZNOŚCI TRZECH FLUOROCHINOLONÓW DLA RZĘSY DROBNEJ LEMNA MINOR

Magdalena Bielińska; Grzegorz Nałęcz-Jawecki

doi:10.56782/pps.64

Published : 2009-09-17

Vol. 7 No. 4 (2009)

PHARMACEUTICALS IN THE ENVIRONMENT. I: EVALUATION OF TOXICITY OF THREE FLUOROQUINOLONES TO DUCKWEED LEMNA MINOR

Magdalena Bielińska

Grzegorz Nałęcz-Jawecki

DOI: https://doi.org/10.56782/pps.64

Abstract

Drugs used in human and veterinary medicine belong to a new class of environmental pollutants. Antibiotics and chemotherapeutics may produce biological effects at very low concentrations. Moreover, the continuous exposure of bacteria to even small concentrations of antibiotics or active metabolites could lead to the emergence of resistant bacteria strains. Antibiotics also may have high biological activity against non-target organisms as plants. In case of duckweed (Lemna minor) the EC₂₀ values for fluoroquinolones as ciprofloxacin, ofloxacin and lomefloxacin are 64, 100 and 370 μg/l, respectively.

Keywords:

fluoroquinolones, ecotoxicology, duckweed, drugs in the environment

Similar Articles

Maciej Bara, Agata Janczak, Toxicity of anesthetic gases: exposure in operating rooms and influence on the environment , Prospects in Pharmaceutical Sciences: Vol. 21 No. 3 (2023)
Agnieszka Sienicka, Krzysztof Kubasik, Agata Pisula, The glucagon-like peptide-1 analogues therapy in the non-diabetic patients , Prospects in Pharmaceutical Sciences: Vol. 21 No. 1 (2023)
Paulina Oleksa, Daria Żuraw, Kacper Jasiński, Mateusz Sobczyk, Mikołaj Porzak, Alicja Sodolska, Karolina Haczkur-Pawłowska, Drugs and other chemical substances inducing diabetes – review of the literature , Prospects in Pharmaceutical Sciences: Vol. 22 No. 2 (2024)
Bartosz Kózka, Karolina Bębas, POZOSTAŁOŚCI SUBSTANCJI FARMAKOLOGICZNIE CZYNNYCH JAKO ZANIECZYSZCZENIE ŚRODOWISKA I ROLA GRZYBÓW BIAŁEJ ZGNILIZNY W ICH USUWANIU , Prospects in Pharmaceutical Sciences: Vol. 19 No. 5 (2021)
Bartłomiej Pyrak, Karolina Rogacka, Dariusz Maciej Pisklak, Anti-leukotriene drugs in the therapy of inflammatory diseases , Prospects in Pharmaceutical Sciences: Vol. 20 No. 2 (2022)
Paulina Brewczyńska, Justyna Makowska, Dorota Skrajnowska, Marta Teryks, Andrzej Tokarz, ADDICTION TO CONVENTIONAL AND ELECTRONIC CIGARETTES AND THE RISKS OF PHARMACOTHERAPY IN SMOKERS. , Prospects in Pharmaceutical Sciences: Vol. 13 No. 3 (2015)
Piotr Bojanowski, Piotr F. J. Lipiński, Paweł Czekała, Dariusz Plewczyński, MULTITARGET DRUGS – A NEW PARADIGM IN DRUG DESIGN , Prospects in Pharmaceutical Sciences: Vol. 11 No. 1 (2013)
Joanna Warguła, Outline of the history of drug synthesis with particular emphasis on anticancer and antibacterial drugs , Prospects in Pharmaceutical Sciences: Vol. 20 No. 3 (2022)
Angelika Lis, Katarzyna Wyszomierska, Katarzyna Znajdek, Łukasz Szeleszczuk, Monika Zielińska-Pisklak, PHOTOSENSITIVITY PHENOMENON – A SIGNIFICANT ADVERSE EFFECT OF COMMONLY USED DRUGS , Prospects in Pharmaceutical Sciences: Vol. 19 No. 3 (2021)
Aneta Emilia Jabłońska, Krzysztof Adam Stępień, COUNTERFEITING OF MEDICINAL PRODUCTS AND THREATS ASSOCIATED WITH THEIR TAKING , Prospects in Pharmaceutical Sciences: Vol. 17 No. 11 (2019)

1 2 3 4 5 6 7 > >>

You may also start an advanced similarity search for this article.

Details

References

Statistics

Authors

Download files

PDF (Język Polski)

Citation rules

Bielińska, M., & Nałęcz-Jawecki, G. (2009). PHARMACEUTICALS IN THE ENVIRONMENT. I: EVALUATION OF TOXICITY OF THREE FLUOROQUINOLONES TO DUCKWEED LEMNA MINOR. Prospects in Pharmaceutical Sciences, 7(4), 24–30. https://doi.org/10.56782/pps.64

Altmetric indicators

Cited by / Share

Licence

This work is licensed under a Creative Commons Attribution 4.0 International License.

References

Ball P. (2000). Quinolone generations: natural history or natural selection? J Antimicrob Chemotherapy 46: 17-24. DOI: https://doi.org/10.1093/oxfordjournals.jac.a020889

Brain R.A., Johnson D.J., Richards S.M., Sanderson H., Sibley P.K., Solomon K.R. (2004). Effects of 25 pharmaceutical compounds to Lemna gibba using a seven-day static-reneval test. Environ Toxicol Chem. 23: 371-382. DOI: https://doi.org/10.1897/02-576

Breton R., Boxall A. (2003). Pharmaceuticals and personal care products in the environment: Regulatory drivers and research needs. QSAR & Combinatorial Sci. 22: 399-409. DOI: https://doi.org/10.1002/qsar.200390030

Cleuvers M. (2003). Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett. 142: 185-194. DOI: https://doi.org/10.1016/S0378-4274(03)00068-7

Daughton C.G., Ternes T.A. (1999). Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Prospect. 107: 907-938. DOI: https://doi.org/10.1289/ehp.99107s6907

Duong H.A., Pham N.H., Nguyen H.T., Hoang T.T., Pham H.V., Pham V.C., Berg M., Giger W., Alder A.C. (2008). Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam. Chemosphere 72: 968-973. DOI: https://doi.org/10.1016/j.chemosphere.2008.03.009

Fent K., Weston A.A., Caminada D. (2006). Ecotoxicology of human pharmaceuticals. Aquat Toxicol. 76: 122-159. DOI: https://doi.org/10.1016/j.aquatox.2005.09.009

Golet E.M., Xifra I., Siegrist H., Alder A.C., Giger W. (2003). Enviornmental exposure assessment of fluoroquinolone antibacterial agents from sewage to soil. Enviorn Sci Technol. 37: 3243-3249. DOI: https://doi.org/10.1021/es0264448

Hirsch R., Ternes T., Haberer K., Kratz K-L. (1999). Occurrence of antibiotics in the aquatic environment. Sci Total Environ. 225: 109-118. DOI: https://doi.org/10.1016/S0048-9697(98)00337-4

ISO 8692. (1993). Water Quality – Algal Growth Inhibition Test. International Organisation for Standardisation.

ISO DIS 20079. Water Quality - Determination of the Toxic Effect of Water Constituents and Waste Water to Duckweed (Lemna minor) - Duckweed Growth Inhibition Test. International Organisation for Standardisation.

Kümmerer K. (2001). Drugs in the environment: emission of drugs, diagnostic aids and didinfectants into wastewater by hospitals in relation to other sources – a review. Chemosphere 45: 957-969. DOI: https://doi.org/10.1016/S0045-6535(01)00144-8

Mohan B.S., Hosetti B.B. (1999). Aquatic Plants for Toxicity Assessment. Environ Res Section A. 81: 259-274. DOI: https://doi.org/10.1006/enrs.1999.3960

OECD 201. (2006). Freshwater Alga and Cyanobacteria, Growth Inhibition Test. Guideline for the testing of chemicals. OECD. Organisation for Economic Co-operation and Development, Paris.

OECD 221. (2006). Lemna sp. Growth Inhibition Test. Guideline for the testing of chemicals. OECD. Organisation for Economic Co-operation and Development, Paris.

Picó Y., Andreu V. (2007). Fluoroquinolones in soil: risks and challenges. Anal Bioanal Chem. 387: 1287-1299. DOI: https://doi.org/10.1007/s00216-006-0843-1

Robinson A.A., Belden J.B., Lydy M.J. (2005). Toxicity of fluoroquinolone antibiotics to aquatic organisms. Environ Toxicol Chem. 24: 423-430. DOI: https://doi.org/10.1897/04-210R.1

Magdalena Bielińska

Affiliation:

Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny Zakład Badania Środowiska, Poland

Grzegorz Nałęcz-Jawecki

Affiliation:

Wydział Farmaceutyczny, Warszawski Uniwersytet Medyczny Zakład Badania Środowiska, Poland

PHARMACEUTICALS IN THE ENVIRONMENT. I: EVALUATION OF TOXICITY OF THREE FLUOROQUINOLONES TO DUCKWEED LEMNA MINOR

Magdalena Bielińska

Grzegorz Nałęcz-Jawecki

Abstract

Keywords:

Most read articles by the same author(s)

Similar Articles

Magdalena Bielińska

Grzegorz Nałęcz-Jawecki