Humulus Species: A Traditional Medicinal Plant and Its Modern Pharmacological Importance

Ghadir A. El-Chaghaby; Emre Sevindik; Mustafa Sevindik; Oguzhan Koçer; Imran Uysal

doi:10.56782/pps.388

Published : 2025-08-06

No. 2025 (Early Access)

Humulus Species: A Traditional Medicinal Plant and Its Modern Pharmacological Importance

Ghadir A. El-Chaghaby

Emre Sevindik

Mustafa Sevindik

Oguzhan Koçer

Imran Uysal

DOI: https://doi.org/10.56782/pps.388

Abstract

The genus Humulus, particularly Humulus lupulus (hops), has been widely recognized for its historical and traditional uses in various cultures due to its diverse biological activities. This review compiles the general characteristics, traditional uses, essential oil compositions, and pharmacological properties of Humulus species, with a focus on their antioxidant, antimicrobial, anti-inflammatory, anticancer, antiviral, and insecticidal activities. The essential oils of Humulus species, rich in bioactive compounds such as β-caryophyllene, α-humulene, and β-myrcene, contribute to their broad-spectrum therapeutic effects. These compounds have demonstrated significant potential in reducing oxidative stress, combating microbial infections, alleviating inflammation, and exhibiting cytotoxic effects against cancer cells. Additionally, the traditional uses of Humulus species for sleep regulation, digestive health, and hormone balance are supported by modern pharmacological studies. The antioxidant and antimicrobial properties of Humulus species highlight their potential as natural sources of antioxidants and alternatives to synthetic antibiotics, particularly in the face of rising antibiotic resistance. Furthermore, the insecticidal and allelopathic effects of these plants suggest their applicability in sustainable agriculture as eco-friendly biopesticides and weed control agents. Despite the promising findings, gaps remain in understanding the pharmacokinetics, bioavailability, and safe dosage ranges of the bioactive compounds in Humulus species. Future research should focus on in vivo and clinical studies to validate these effects, explore their potential in functional foods and nutraceuticals, and assess their ecological and environmental impacts for large-scale cultivation. In conclusion, Humulus species represent a versatile and valuable natural resource with significant potential in medicine, agriculture, and industry. Continued research efforts are essential to fully unlock their benefits and integrate them into modern therapeutic and industrial applications.

Keywords:

Hop, Humulus, complementary medicine, medicinal plants, antioxidant

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El-Chaghaby, G. A., Sevindik, E., Sevindik, M., Koçer, O., & Uysal, I. (2025). Humulus Species: A Traditional Medicinal Plant and Its Modern Pharmacological Importance. Prospects in Pharmaceutical Sciences, (2025 (Early Access). https://doi.org/10.56782/pps.388

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References

1. Sevindik, M., Akgul, H., Pehlivan, M. and Selamoglu, Z., Fresen Environ Bull, 2017, vol. 26, no. 7, pp. 4757-4763.

2. Mohammed, F. S., Günal, S., Şabik, A. E., Akgül, H. and Sevindik, M., Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 2020, vol. 23, no. 5, pp. 1114-1118. DOI: https://doi.org/10.18016/ksutarimdoga.vi.699457

3. Korkmaz, N., Dayangaç, A., Sevindik, M., Journal of Faculty of Pharmacy of Ankara University, 2021, vol. 45, no. 3, pp. 554-564. DOI: https://doi.org/10.33483/jfpau.977776

4. Mohammed, F. S., Korkmaz, N., Doğan, M., Şabik, A. E., & Sevindik, M. (2021a). Some medicinal properties of Glycyrrhiza glabra (Licorice). Journal of Faculty of Pharmacy of Ankara University, 45(3), 524-534. DOI: https://doi.org/10.33483/jfpau.979200

5. Alinkina, E. S., Vorobyova, A. K., Misharina, T. A., Fatkullina, L. D., Burlakova, E. B., & Khokhlov, A. N. (2012). Cytogerontological studies of biological activity of oregano essential oil. Moscow University biological sciences bulletin, 67, 52-57. DOI: https://doi.org/10.3103/S0096392512020022

6. Sevindik, M., Uygun, A. E., Uysal, I., & Sabik, A. E. (2025). A Comprehensive Review on the Biological Activities, Usage Areas, Chemical and Phenolic Compositions of Lycium barbarum Used in Traditional Medicine Practices. Science and Technology Indonesia, 10(1):173-182 DOI: https://doi.org/10.26554/sti.2025.10.1.173-182

7. Mohammed, F. S., Akgul, H., Sevindik, M., & Khaled, B. M. T. (2018). Phenolic content and biological activities of Rhus coriaria var. zebaria. Fresenius Environmental Bulletin, 27(8), 5694-5702.

8. Sevindik, M., Gürgen, A., Krupodorova, T., Uysal, İ., & Koçer, O. (2024). A hybrid artificial neural network and multi-objective genetic algorithm approach to optimize extraction conditions of Mentha longifolia and biological activities. Scientific Reports, 14(1), 31403. DOI: https://doi.org/10.1038/s41598-024-83029-8

9. Sevindik, M., Uysal, İ., Sevindik, E., Krupodorova, T., Koçer, O., & Ünal, O. (2024). Citrullus colocynthis (Bitter-apple): a comprehensive review on general properties, biological activities, phenolic and chemical contents. Notulae Scientia Biologicae, 16(4), 12202-12202. DOI: https://doi.org/10.55779/nsb16412202

10. Mohammed, F. S., Karakaş, M., Akgül, H., & Sevindik, M. (2019). Medicinal properties of Allium calocephalum collected from Gara Mountain (Iraq). Fresen Environ Bull, 28(10), 7419-7426.

11. Sim, L. Y., Abd Rani, N. Z., & Husain, K. (2019). Lamiaceae: An insight on their anti-allergic potential and its mechanisms of action. Frontiers in pharmacology, 10, 677. DOI: https://doi.org/10.3389/fphar.2019.00677

12. Uysal, I., Sevindik, M., Dogan, M., Mohammed, F. S., Seğmenoğlu, M. S., & Pehlivan, M. (2024). Biological Activities, Phenolic Contents and Chemical Compositions of Essential Oils and Different Extracts of Origanum laevigatum. Pharmaceutical Chemistry Journal, 58(8), 1289-1297. DOI: https://doi.org/10.1007/s11094-024-03272-1

13. Gürgen, A., Sevindik, M., Krupodorova, T., Uysal, I., & Unal, O. (2024). Biological activities of Hypericum spectabile extract optimized using artificial neural network combined with genetic algorithm application. BMC biotechnology, 24(1), 83. DOI: https://doi.org/10.1186/s12896-024-00914-w

14. Mohammed, F. S., Pehlivan, M., Sevindik, E., Akgul, H., Sevindik, M., Bozgeyik, I., & Yumrutas, O. (2021b). Pharmacological properties of edible Asparagus acutifolius and Asparagus officinalis collected from North Iraq and Turkey (Hatay). Acta Alimentaria, 50(1), 136-143. DOI: https://doi.org/10.1556/066.2020.00204

15. Unal, O., Eraslan, E. C., Uysal, I., Mohammed, F. S., Sevindik, M., & Akgul, H. (2022). Biological activities and phenolic contents of Rumex scutatus collected from Turkey. Fresenius Environmental Bulletin, 31(7), 7341-7346.

16. Ayenew, K. D., & Wasihun, Y. (2023). Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats. BMC Complementary Medicine and Therapies, 23(1), 1-8. DOI: https://doi.org/10.1186/s12906-023-03931-y

17. Laha, A., Sarkar, A., Chakraborty, P., Panja, A. S., & Bandopadhyay, R. (2023). Efficacy screening of prospective anti-allergic drug candidates: An in silico study. Current Bioinformatics, 18(2), 143-153. DOI: https://doi.org/10.2174/1574893618666221019092212

18. Yazar, M., Sevindik, M., Polat, A. O., Koçer, O., Karatepe, H. K., & Uysal, İ. (2024). General properties, biosynthesis, pharmacological properties, biological activities and daily uses of luteolin. Prospects in Pharmaceutical Sciences, 22(4), 146-154. DOI: https://doi.org/10.56782/pps.286

19. Uysal, I., Koçer, O., Mohammed, F. S., Lekesiz, Ö., Doğan, M., Şabik, A. E., Sevindik, E., Gerçeker, F.O., & Sevindik, M. (2023). Pharmacological and Nutritional Properties: Genus Salvia. Advances in Pharmacology and Pharmacy, 11(2): 140-155 DOI: https://doi.org/10.13189/app.2023.110206

20. Mohammed, F. S., Sevindik, M., Uysal, İ., Çesko, C., & Koraqi, H. (2024). Chemical Composition, Biological Activities, Uses, Nutritional and Mineral Contents of Cumin (Cuminum cyminum). Measurement: Food, 100157. DOI: https://doi.org/10.1016/j.meafoo.2024.100157

21. Moir, M. (2000). Hops—a millennium review. Journal of the American Society of Brewing Chemists, 58(4), 131-146. DOI: https://doi.org/10.1094/ASBCJ-58-0131

22. Zanoli, P., Zavatti, M. (2008). Pharmacognostic and pharmacological profile of Humulus lupulus L. Journal of ethnopharmacology, 116(3), 383-396. DOI: https://doi.org/10.1016/j.jep.2008.01.011

23. Dostálek, P., Karabín, M., Jelínek, L. (2017). Hop phytochemicals and their potential role in metabolic syndrome prevention and therapy. Molecules, 22(10), 1761. DOI: https://doi.org/10.3390/molecules22101761

24. Girisa, S., Saikia, Q., Bordoloi, D., Banik, K., Monisha, J., Daimary, U. D., Kunnumakkara, A. B. (2021). Xanthohumol from Hop: Hope for cancer prevention and treatment. IUBMB life, 73(8), 1016-1044. DOI: https://doi.org/10.1002/iub.2522

25. Korpelainen, H., Pietiläinen, M. (2021). Hop (Humulus lupulus L.): Traditional and present use, and future potential. Economic botany, 1-21. DOI: https://doi.org/10.1007/s12231-021-09528-1

26. Mohammed, F. S., Günal, S., Pehlivan, M., Doğan, M., Sevindik, M., & Akgül, H. (2020b). Phenolic content, antioxidant and antimicrobial potential of endemic Ferulago platycarpa. Gazi University Journal of Science, 33(4), 670-677. DOI: https://doi.org/10.35378/gujs.707555

27. Mohammed, F. S., Kına, E., Sevindik, M., Doğan, M., & Pehlivan, M. (2021c). Antioxidant and antimicrobial activities of ethanol extract of Helianthemum salicifolium (Cistaceae). Indian Journal of Natural Products and Resources (IJNPR)[Formerly Natural Product Radiance (NPR)], 12(3), 459-462.

28. Bhattacharya, S., Virani, S., Zavro, M., Haas, G. J. (2003). Inhibition ofStreptococcus mutans and Other Oral streptococci by hop (Humulus lupulus L.) constituents. Economic Botany, 57(1), 118-125. DOI: https://doi.org/10.1663/0013-0001(2003)057[0118:IOSMAO]2.0.CO;2

29. Frölich, S., Schubert, C., Bienzle, U., Jenett-Siems, K. (2005). In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin. Journal of Antimicrobial Chemotherapy, 55(6), 883-887. DOI: https://doi.org/10.1093/jac/dki099

30. Gerhäuser, C. (2005). Broad spectrum antiinfective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites. Molecular nutrition & food research, 49(9), 827-831. DOI: https://doi.org/10.1002/mnfr.200500091

31. Luzak, B., Golanski, J., Przygodzki, T., Boncler, M., Sosnowska, D., Oszmianski, J., Rozalski, M. (2016). Extract from spent hop (Humulus lupulus L.) reduces blood platelet aggregation and improves anticoagulant activity of human endothelial cells in vitro. Journal of functional Foods, 22, 257-269. DOI: https://doi.org/10.1016/j.jff.2016.01.029

32. Cermak, P., Olsovska, J., Mikyska, A., Dusek, M., Kadleckova, Z., Vanicek, J., Bostik, P. (2017). Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria. Apmis, 125(11), 1033-1038. DOI: https://doi.org/10.1111/apm.12747

33. Kobus-Cisowska, J., Szymanowska-Powałowska, D., Szczepaniak, O., Kmiecik, D., Przeor, M., Gramza-Michałowska, A., Szulc, P. (2019). Composition and in vitro effects of cultivars of Humulus lupulus L. hops on cholinesterase activity and microbial growth. Nutrients, 11(6), 1377. DOI: https://doi.org/10.3390/nu11061377

34. Sangiovanni, E., Fumagalli, M., Santagostini, L., Forino, M., Piazza, S., Colombo, E., Dell'Agli, M. (2019). A bio-guided assessment of the anti-inflammatory activity of hop extracts (Humulus lupulus L. cv. Cascade) in human gastric epithelial cells. Journal of Functional Foods, 57, 95-102. DOI: https://doi.org/10.1016/j.jff.2019.03.041

35. Paventi, G., de Acutis, L., De Cristofaro, A., Pistillo, M., Germinara, G. S., Rotundo, G. (2020). Biological activity of Humulus lupulus (L.) essential oil and its main components against Sitophilus granarius (L.). Biomolecules, 10(8), 1108. DOI: https://doi.org/10.3390/biom10081108

36. Arruda, T. R., Pinheiro, P. F., Silva, P. I. and Bernardes, P. C., LWT, 2021, vol. 141, pp. 110905. DOI: https://doi.org/10.1016/j.lwt.2021.110905

37. Macchioni, V., Carbone, K., Cataldo, A., Fraschini, R., Bellucci, S. (2021). Lactic acid-based deep natural eutectic solvents for the extraction of bioactive metabolites of Humulus lupulus L.: Supramolecular organization, phytochemical profiling and biological activity. Separation and Purification Technology, 264, 118039. DOI: https://doi.org/10.1016/j.seppur.2020.118039

38. Ovidi, E., Laghezza Masci, V., Taddei, A. R., Torresi, J., Tomassi, W., Iannone, M., Garzoli, S. (2022). Hemp (Cannabis sativa L., kompolti cv.) and hop (Humulus lupulus L., chinook cv.) essential oil and hydrolate: HS-GC-MS chemical investigation and apoptotic activity evaluation. Pharmaceuticals, 15(8), 976. DOI: https://doi.org/10.3390/ph15080976

39. Sun, T., Wang, F., Wang, J., Wang, L., Sun, Y. (2012). Insecticidal activity of different solvent extracts and partitioned extracts from Humulus scandens. Journal of Plant Resources and Environment, 21(2), 64-67.

40. Wang, L., Liu, Y., Zhu, X., Zhang, Z., Huang, X. (2021). Identify potential allelochemicals from Humulus scandens (Lour.) Merr. root extracts that induce allelopathy on Alternanthera philoxeroides (Mart.) Griseb. Scientific reports, 11(1), 1-8. DOI: https://doi.org/10.1038/s41598-021-86656-7

41. Zhang, D., Tan, L. H., Feng, Y. J., Yao, L., Yan, X. W., Cao, W. G. (2021). Evaluation of antioxidant, anti-inflammatory activity and identification of active compounds of Humulus scandens. South African Journal of Botany, 141, 126-132. DOI: https://doi.org/10.1016/j.sajb.2021.04.012

42. Krupodorova, T., & Sevindik, M. (2020). Antioxidant potential and some mineral contents of wild edible mushroom Ramaria stricta. AgroLife Scientific Journal, 9(1), 186-191.

43. Bal, C., Sevindik, M., Akgul, H., & Selamoglu, Z. (2019). Oxidative stress index and antioxidant capacity of Lepista nuda collected from Gaziantep/Turkey. Sigma Journal of Engineering and Natural Sciences, 37(1), 1-5. DOI: https://doi.org/10.1155/2020/5620484

44. Selamoglu, Z., Sevindik, M., Bal, C., Ozaltun, B., Sen, İ., & Pasdaran, A. (2020). Antioxidant, antimicrobial and DNA protection activities of phenolic content of Tricholoma virgatum (Fr.) P. Kumm. Biointerface Research in Applied Chemistry, 10 (3), 5500-5506 DOI: https://doi.org/10.33263/BRIAC103.500506

45. Saridogan, B. G. O., Islek, C., Baba, H., Akata, I., & Sevindik, M. (2021). Antioxidant antimicrobial oxidant and elements contents of Xylaria polymorpha and X. hypoxylon (Xylariaceae). Fresenius Environmental Bulletin, 30(5), 5400-5404.

46. Eraslan, E. C., Altuntas, D., Baba, H., Bal, C., Akgül, H., Akata, I., & Sevindik, M. (2021). Some biological activities and element contents of ethanol extract of wild edible mushroom Morchella esculenta. Sigma Journal of Engineering and Natural Sciences, 39(1), 24-28.

47. Sevindik, M. (2021). Anticancer, antimicrobial, antioxidant and DNA protective potential of mushroom Leucopaxillus gentianeus (Quél.) Kotl. Indian Journal of Experimental Biology (IJEB), 59(05), 310-315.

48. Mohammed, F. S., Uysal, I., & Sevindik, M. (2023). A Review on Antiviral Plants Effective Against Different Virus Types. Prospects in Pharmaceutical Sciences, 21(2), 1-21. DOI: https://doi.org/10.56782/pps.128

49. Bal, C., Akgul, H., Sevindik, M., Akata, I., & Yumrutas, O. (2017). Determination of the anti-oxidative activities of six mushrooms. Fresenius Envir Bull, 26(10), 6246-6252.

50. Islek, C., Saridogan, B. G. O., Sevindik, M., & Akata, I. (2021). Biological activities and heavy metal contents of some Pholiota species. Fresenius Environmental Bulletin, 30(6), 6109-6114.

51. Katsiotis, S. T., Langezaal, C. R., Scheffer, J. J. C., Verpoorte, R. (1989). Comparative study of the essential oils from hops of various Humulus lupulus L. cultivars. Flavour and fragrance journal, 4(4), 187-191. DOI: https://doi.org/10.1002/ffj.2730040407

52. Malizia, R. A., Molli, J. S., Cardell, D. A., Grau, R. J. (1999). Essential oil of hop cones (Humulus lupulus L.). Journal of Essential Oil Research, 11(1), 13-15. DOI: https://doi.org/10.1080/10412905.1999.9701056

53. Patzak, J., Matoušek, J., Krofta, K., Svoboda, P. (2001). Hop latent viroid (HLVd)-caused pathogenesis: effects of HLVd infection on lupulin composition of meristem culture-derived Humulus lupulus. Biologia plantarum, 44(4), 579-585. DOI: https://doi.org/10.1023/A:1013798821676

54. Bernotienë, G., Nivinskienë, O., Butkienë, R., Mockutë, D. (2004). Chemical composition of essential oils of hops (Humulus lupulus L.) growing wild in Aukstaitija. Chemija, 15(2), 31-36.

55. Jirovetz, L., Bail, S., Buchbauer, G., Denkova, Z., Slavchev, A., Stoyanova, A., Geissler, M. (2006). Antimicrobial testings, gas chromatographic analysis and olfactory evaluation of an essential oil of hop cones (Humulus lupulus L.) from Bavaria and some of its main compounds. Scientia Pharmaceutica, 74(4), 189. DOI: https://doi.org/10.3797/scipharm.2006.74.189

56. Ligor, M., Stankevičius, M., Wenda-Piesik, A., Obelevičius, K., Ragažinskienė, O., Stanius, Ž., Buszewski, B. (2014). Comparative gas chromatographic–mass spectrometric evaluation of hop (Humulus lupulus L.) essential oils and extracts obtained using different sample preparation methods. Food analytical methods, 7(7), 1433-1442. DOI: https://doi.org/10.1007/s12161-013-9767-5

57. Tyśkiewicz, K., Gieysztor, R., Konkol, M., Szałas, J., Rój, E. (2018). Essential oils from Humulus lupulus scCO2 extract by hydrodistillation and microwave-assisted hydrodistillation. Molecules, 23(11), 2866. DOI: https://doi.org/10.3390/molecules23112866

58. da Rosa Almeida, A., Maciel, M. V. D. O. B., Cardoso Gasparini Gandolpho, B., Machado, M. H., Teixeira, G. L., Bertoldi, F. C., Barreto, P. L. M. (2021). Brazilian grown cascade hop (Humulus Lupulus L.): LC-ESI-MS-MS and GC-MS analysis of chemical composition and antioxidant activity of extracts and essential oils. Journal of the American Society of Brewing Chemists, 79(2), 156-166. DOI: https://doi.org/10.1080/03610470.2020.1795586

59. Jın F., Zhao L.，Zhang Y.，Wu J.，Peng X. (2014). Analysis of Volatile Chemical Constituents of Dried and Fresh Humulus scandens in Guizhou by HS-SPMEGC-MS. China Pharmacy, 25(31), 2931-2934.

60. Peng, X., Shao, J., Liu, B., Zhang, F., Jin, F., Wu, J. (2014). Volatile oil composition and content in different parts of fresh Guizhou Humulus scandens. Guizhou Agricultural Sciences, 42(4), 178-181.

61. Fidyt, K., Fiedorowicz, A., Strządała, L., & Szumny, A. (2016). β‐caryophyllene and β‐caryophyllene oxide—natural compounds of anticancer and analgesic properties. Cancer medicine, 5(10), 3007-3017. DOI: https://doi.org/10.1002/cam4.816

62. Francomano, F., Caruso, A., Barbarossa, A., Fazio, A., La Torre, C., Ceramella, J., ... & Sinicropi, M. S. (2019). β-Caryophyllene: a sesquiterpene with countless biological properties. Applied sciences, 9(24), 5420. DOI: https://doi.org/10.3390/app9245420

63. de Lacerda Leite, G. M., de Oliveira Barbosa, M., Lopes, M. J. P., de Araújo Delmondes, G., Bezerra, D. S., Araújo, I. M., ... & Kerntof, M. R. (2021). Pharmacological and toxicological activities of α-humulene and its isomers: A systematic review. Trends in Food Science & Technology, 115, 255-274. DOI: https://doi.org/10.1016/j.tifs.2021.06.049

64. Surendran, S., Qassadi, F., Surendran, G., Lilley, D., & Heinrich, M. (2021). Myrcene—what are the potential health benefits of this flavouring and aroma agent?. Frontiers in nutrition, 8, 699666. DOI: https://doi.org/10.3389/fnut.2021.699666

65. Meznar, B., Kajba, S. (1990). Bronchial responsiveness in hops processing workers. Plucne Bolesti: Casopis Udruzenja Pneumoftiziologa Jugoslavije= the Journal of Yugoslav Association of Phthisiology and Pneumology, 42(1-2), 27-29.

66. Skórska, C., Mackiewicz, B., Góra, A., Golec, M., Dutkiewicz, J. (2003). Health effects of inhalation exposure to organic dust in hops farmers. In Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, 58(1), 459-465.

67. Godnic‐Cvar, J., Zuskin, E., Mustajbegovic, J., Schachter, E. N., Kanceljak, B., Macan, J., Ebling, Z. (1999). Respiratory and immunological findings in brewery workers. American journal of industrial medicine, 35(1), 68-75. DOI: https://doi.org/10.1002/(SICI)1097-0274(199901)35:1<68::AID-AJIM9>3.0.CO;2-#

68. Spiewak, R., Dutkiewicz, J. (2002). Occupational airborne and hand dermatitis to hop [Humulus lupulus] with non-occupational relapses. Annals of Agricultural and Environmental Medicine, 9(2).

Ghadir A. El-Chaghaby

ghadiraly@yahoo.com

Affiliation:

Bioanalysis Laboratory, Regional Center for Food and Feed, Agricultural Research Center, Giza, Egypt Turkey

Emre Sevindik

ph.d-emre@hotmail.com

Affiliation:

Department of Agricultural Biotechnology, Faculty of Agriculture, Aydın Adnan Menderes University, Türkiye Turkey

Mustafa Sevindik

sevindik27@gmail.com

Affiliation:

a:1:{s:5:"en_US";s:115:"Osmaniye Korkut Ata University, Faculty of Science and Literature, Department of Biology, Osmaniye, 80000, Türkiye";} Turkey

Oguzhan Koçer

oguzhankocer@hotmail.com

Affiliation:

Department of Pharmacy Services, Vocational School of Health Services, Osmaniye Korkut Ata University, Türkiye Turkey

Imran Uysal

uysal-imran@hotmail.com

Affiliation:

Department of Food Processing, Bahçe Vocational School of Higher Education, University of Osmaniye Korkut Ata, Türkiye Turkey

Humulus Species: A Traditional Medicinal Plant and Its Modern Pharmacological Importance

Ghadir A. El-Chaghaby

Emre Sevindik

Mustafa Sevindik

Oguzhan Koçer

Imran Uysal

Abstract

Keywords:

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