Comprehensive review of topical phytoformulations and pharmacological activities for the treatment of wrinkles
DOI:
https://doi.org/10.56782/pps.503Keywords:
Anti-wrinkles, pharmacological activity, Traditional plants, collagen, elastinAbstract
The rising demand for natural cosmeceuticals is primarily attributed to their minimal side effects and their potential as alternatives to synthetic drugs. Numerous plant-derived compounds have been identified with properties beneficial for skin care, including whitening, anti-aging, and anti-wrinkle effects, as shown in the graphical abstract. This review comprehensively evaluates the efficacy of various herbal remedies for wrinkle treatment, drawing evidence from clinical studies, experimental research, and traditional practices. The study is aimed to identify medicinal plants with substantial scientific support for their therapeutic benefits, particularly in wrinkle reduction. An extensive literature search was conducted using databases such as PubMed, Google Scholar, Scopus, Web of Science, and ScienceDirect. The Plant List database was also consulted to confirm the scientific names, plant families, traditional uses, and active constituents of each plant. The analysis revealed 23 plant species from 19 different families that are traditionally used for managing symptoms of premature aging, including wrinkles and pimples. These plants were reviewed for their mechanisms of action, bioactive constituents, availability, and potential applications in cosmetic formulations. Scientific studies have confirmed that phytoconstituents possess anti-inflammatory, photoprotective, and anti-wrinkle properties, with proven inhibitory effects on wrinkle-related enzymes such as elastase and collagenase. Key botanicals such as Diospyros kaki, Ipomoea carnea, Calendula officinalis, Ocimum basilicum, and Moringa oleifera have shown significant cosmeceutical potential. Overall, the findings suggest that phytoconstituents from medicinal plants represent promising and potentially superior alternatives to synthetic agents for the development of effective anti-wrinkle treatments.
Downloads
References
1. Ahuja, A.; Gupta, J.; Gupta, R. Miracles of Herbal Phytomedicines in Treatment of Skin Disorders: Natural Healthcare Perspective. Infect. Disord. Drug Targets 2020, 21, 328–338. DOI: 10.2174/1871526520666200622142710 DOI: https://doi.org/10.2174/1871526520666200622142710
2. Kim, J.H.; Gao, D.; Jeong, W.S.; Kim, C.T.; Cho, C.W.; Kim, H.M.; Kang, J.S. Anti-Wrinkle Effect of Isatis indigotica Leaf Extract: Evaluation of Antioxidant, Anti-Inflammation, and Clinical Activity. Antioxidants 2021, 10, Art. No: 1339. DOI: 10.3390/antiox10091339 DOI: https://doi.org/10.3390/antiox10091339
3. Miastkowska, M.; Sikora, E. Anti-Aging Properties of Plant Stem Cell Extracts. Cosmetics 2018, 5, Art. No: 55. DOI: 10.3390/cosmetics5040055 DOI: https://doi.org/10.3390/cosmetics5040055
4. Wang, J.; Chen, Y.; He, J.; Li, G.; Chen, X.; Liu, H. Anti-Aging Effect of the Stromal Vascular Fraction/Adipose-Derived Stem Cells in a Mouse Model of Skin Aging Induced by UVB Irradiation. Front. Surg. 2022, 9, Art. No: 950967. DOI: 10.3389/fsurg.2022.950967 DOI: https://doi.org/10.3389/fsurg.2022.950967
5. Jiratchayamaethasakul, C.; Ding, Y.; Hwang, O.; Im, S.T.; Jang, Y.; Myung, S.W.; Lee, J.M.; Kim, H.S.; Ko, S.C.; Lee, S.H. In Vitro Screening of Elastase, Collagenase, Hyaluronidase, and Tyrosinase Inhibitory and Antioxidant Activities of 22 Halophyte Plant Extracts for Novel Cosmeceuticals. Fish. Aquat. Sci. 2020, 23, Art. No: 1. DOI: 10.1186/s41240-020-00149-8 DOI: https://doi.org/10.1186/s41240-020-00149-8
6. Yoshikawa, M.; Okano, Y.; Masaki, H. An Ocimum basilicum Extract Containing Rosmarinic Acid Restores the Disruption of Collagen Fibers Caused by Repetitive UVA Irradiation of Dermal Fibroblasts. J. Oleo Sci. 2020, 69, 1487–1495. DOI: 10.5650/jos.ess20129 DOI: https://doi.org/10.5650/jos.ess20129
7. Im, A.; Nam, J.; Ji, K.; Cha, S.; Yoon, J.; Seo, Y.K.; Chae, S.; Kim, J.Y. Wrinkle Reduction Using a Topical Herbal Cream in Subjects Classified by Sasang Constitutional Medicine as Soyang Type: A Randomized Double-Blind Placebo-Controlled Study. Eur. J. Integr. Med. 2020, 35, Art. No: 101070. DOI: 10.1016/j.eujim.2020.101070 DOI: https://doi.org/10.1016/j.eujim.2020.101070
8. Chen, H.J.; Dai, F.J.; Chen, C.Y.; Fan, S.L.; Zheng, J.H.; Huang, Y.C.; Chau, C.F.; Lin, Y.S.; Chen, C.S. Evaluating the Antioxidants, Whitening and Antiaging Properties of Rice Protein Hydrolysates. Molecules 2021, 26, Art. No: 3605. DOI: 10.3390/molecules26123605 DOI: https://doi.org/10.3390/molecules26123605
9. Philips, N.; Auler, S.; Hugo, R.; Gonzalez, S. Beneficial Regulation of Matrix Metalloproteinases for Skin Health. Enzyme Res. 2011, 2011, Art. No: 427285. DOI: 10.4061/2011/427285 DOI: https://doi.org/10.4061/2011/427285
10. Babich, O.; Ivanova, S.; Bakhtiyarova, A.; Kalashnikova, O.; Sukhikh, S. Medicinal Plants Are the Basis of Natural Cosmetics. Process Biochem. 2025, 154, 35–51. DOI: 10.1016/j.procbio.2025.04.009 DOI: https://doi.org/10.1016/j.procbio.2025.04.009
11. Hussein, R.S.; Bin Dayel, S.; Abahussein, O.; El-Sherbiny, A.A. Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. J. Cosmet. Dermatol. 2025, 24, Art. No: e16688. DOI: 10.1111/jocd.16688
12. Gambini, J.; Stromsnes, K. Oxidative Stress and Inflammation: From Mechanisms to Therapeutic Approaches. Biomedicines 2022, 10, Art. No: 753. DOI: 10.3390/biomedicines10040753 DOI: https://doi.org/10.3390/biomedicines10040753
13. Kamelnia, E.; Mohebbati, R.; Kamelnia, R.; El-Seedi, H.R.; Boskabady, M.H. Anti-Inflammatory, Immunomodulatory and Anti-Oxidant Effects of Ocimum basilicum L. and Its Main Constituents: A Review. Iran. J. Basic Med. Sci. 2023, 26, 617–627. DOI: 10.22038/IJBMS.2023.67466.14783
14. Xu, Y.; Chen, G.; Guo, M. Potential Anti-Aging Components from Moringa oleifera Leaves Explored by Affinity Ultrafiltration with Multiple Drug Targets. Front. Nutr. 2022, 9, Art. No: 854882. DOI: 10.3389/fnut.2022.854882 DOI: https://doi.org/10.3389/fnut.2022.854882
15. Hwang, K.C.; Shin, H.Y.; Kim, W.J.; Seo, M.S.; Kim, H. Effects of a High-Molecular-Weight Polysaccharide Isolated from Korean Persimmon on the Antioxidant, Anti-Inflammatory, and Antiwrinkle Activity. Molecules 2021, 26, Art. No: 1600. DOI: 10.3390/molecules26061600 DOI: https://doi.org/10.3390/molecules26061600
16. Hussein, R.S.; Bin Dayel, S.; Abahussein, O.; El-Sherbiny, A.A. Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights. J. Cosmet. Dermatol. 2025, 24, Art. No: e16688. DOI: 10.1111/jocd.16688 DOI: https://doi.org/10.1111/jocd.16688
17. Abdulkhaleq, L.A.; Assi, M.A.; Abdullah, R.; Zamri-Saad, M.; Taufiq-Yap, Y.H.; Hezmee, M.N.M. The Crucial Roles of Inflammatory Mediators in Inflammation: A Review. Vet. World 2018, 11, 627–635. DOI: 10.14202/vetworld.2018.627-635 DOI: https://doi.org/10.14202/vetworld.2018.627-635
18. He, X.; Wan, F.; Su, W.; Xie, W. Research Progress on Skin Aging and Active Ingredients. Molecules 2023, 28, Art. No: 5556. DOI: 10.3390/molecules28145556 DOI: https://doi.org/10.3390/molecules28145556
19. Quan, T.; Qin, Z.; Xia, W.; Shao, Y.; Voorhees, J.J.; Fisher, G.J. Matrix-Degrading Metalloproteinases in Photoaging. J. Investig. Dermatol. Symp. Proc. 2009, 14, 20–24. DOI: 10.1038/JIDSYMP.2009.8 DOI: https://doi.org/10.1038/jidsymp.2009.8
20. Tomas M, Günal-Köroğlu D, Kamiloglu S, Ozdal T, Capanoglu E. The state of the art in anti-aging: plant-based phytochemicals for skin care. Immun. Ageing. 2025, 22, Art. No: 5. DOI: 10.1186/s12979-025-00498-9 DOI: https://doi.org/10.1186/s12979-025-00498-9
21. Cerulli, A.; Masullo, M.; Montoro, P.; Piacente, S. Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients. Cosmetics 2022, 9, Art. No: 7. DOI: 10.3390/cosmetics9010007 DOI: https://doi.org/10.3390/cosmetics9010007
22. Buckner, C.A.; Lafrenie, R.M.; Dénommée, J.A.; Caswell, J.M.; Want, D.A. Complementary and Alternative Medicine Use in Patients before and after a Cancer Diagnosis. Curr. Oncol. 2018, 25, e275–e281. DOI: 10.3747/co.25.3884 DOI: https://doi.org/10.3747/co.25.3884
23. Shin-Hae, L.; Kyung-Jin, M. Life-Extending Effect of Phytochemicals in Drosophila. In Phytochemicals in Health and Disease; Springer International Publishing: Cham, Switzerland, 2015; pp. 229–244. DOI: 10.1007/978-3-319-18326-8_10 DOI: https://doi.org/10.1007/978-3-319-18326-8_10
24. Shin, J.W.; Kwon, S.H.; Choi, J.Y.; Na, J.I.; Huh, C.H.; Choi, H.R.; Park, K.C. Molecular Mechanisms of Dermal Aging and Antiaging Approaches. Int. J. Mol. Sci. 2019, 20, Art. No: 2126. DOI: 10.3390/ijms20092126 DOI: https://doi.org/10.3390/ijms20092126
25. Saraf, S.; Kaur, C. Phytoconstituents as Photoprotective Novel Cosmetic Formulations. Pharmacogn. Rev. 2010, 4, 1–11. DOI: 10.4103/0973-7847.65319 DOI: https://doi.org/10.4103/0973-7847.65319
26. Sundar, M.; Lingakumar, K. Investigating the Efficacy of Topical Application of Ipomoea carnea Herbal Cream in Preventing Skin Damage Induced by UVB Radiation in a Rat Model. Heliyon 2023, 9, Art. No: e19161. DOI: 10.1016/j.heliyon.2023.e19161
27. Costa, E.F.; Magalhães, W.V.; Di Stasi, L.C. Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications. Molecules 2022, 27, Art. No: 7518. DOI: 10.3390/molecules27217518 DOI: https://doi.org/10.3390/molecules27217518
28. Moldovan, M.; Lahmar, A.; Bogdan, C.; Parauan, S.; Tomuţă, I.; Crişan, M. Formulation and Evaluation of a Water-in-Oil Cream Containing Herbal Active Ingredients and Ferulic Acid. Clujul Med. 2017, 90, 212–219. DOI: 10.15386/cjmed-668. DOI: https://doi.org/10.15386/cjmed-668
29. Of, I.; Myxa, C.; Loaded, E.; For, E.; Protection, U.V. Emulsion for UV Protection and Anti-Aging. J. Popul. Ther. Clin. Pharmacol. 2023, 30, 2382–2396. DOI: 10.53555/jptcp.v30i18.3300
30. Quan, T.; Fisher, G.J. Role of Age-Associated Alterations of the Dermal Extracellular Matrix Microenvironment in Human Skin Aging: A Mini-Review. Gerontology 2015, 61, 427–434. DOI: 10.1159/000371708 DOI: https://doi.org/10.1159/000371708
31. Ota, Y.; Yoshida, H.; Endo, Y.; Sayo, T.; Takahashi, Y. A Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal Function. Int. J. Mol. Sci. 2022, 23, Art. No: 2424. DOI: 10.3390/ijms23052424 DOI: https://doi.org/10.3390/ijms23052424
32. Shin, S.H.; Lee, Y.H.; Rho, N.K.; Park, K.Y. Skin Aging from Mechanisms to Interventions: Focusing on Dermal Aging. Front. Physiol. 2023, 14, Art. No: 1195272. DOI: 10.3389/fphys.2023.1195272 DOI: https://doi.org/10.3389/fphys.2023.1195272
33. Michalak, M. Plant-Derived Antioxidants: Significance in Skin Health and the Ageing Process. Int. J. Mol. Sci. 2022, 23, Art. No: 585. DOI: 10.3390/ijms23020585 DOI: https://doi.org/10.3390/ijms23020585
34. Kashif, M.; Akhtar, N.; Mustafa, R. An Overview of Dermatological and Cosmeceutical Benefits of Diospyros kaki and Its Phytoconstituents. Rev. Bras. Farmacogn. 2017, 27, 650–662. DOI: 10.1016/j.bjp.2017.06.004 DOI: https://doi.org/10.1016/j.bjp.2017.06.004
35. Sundar, M.; Lingakumar, K. Investigating the Efficacy of Topical Application of Ipomoea carnea Herbal Cream in Preventing Skin Damage Induced by UVB Radiation in a Rat Model. Heliyon 2023, 9, Art. No: e19161. DOI: 10.1016/j.heliyon.2023.e19161 DOI: https://doi.org/10.1016/j.heliyon.2023.e19161
36. Lohani, A.; Mishra, A.K.; Verma, A. Cosmeceutical Potential of Geranium and Calendula Essential Oil: Determination of Antioxidant Activity and in Vitro Sun Protection Factor. J. Cosmet. Dermatol. 2019, 18, 550–557. DOI: 10.1111/jocd.12789 DOI: https://doi.org/10.1111/jocd.12789
37. Akhtar, N.; Shahiq-uz-Zaman; Khan, B.A.; Haji, M.; Khan, S.; Ahmad, M.; Rasool, F.; Mahmood, T.; Rasul, A. Evaluation of Various Functional Skin Parameters Using a Topical Cream of Calendula officinalis Extract. Afr. J. Pharm. Pharmacol. 2011, 5, 199–206. DOI: 10.5897/AJMR10.368 DOI: https://doi.org/10.5897/AJMR10.368
38. Hoang, H.T.; Moon, J.Y.; Lee, Y.C. Natural Antioxidants from Plant Extracts in Skincare Cosmetics: Recent Applications, Challenges and Perspectives. Cosmetics 2021, 8, Art. No: 106. DOI: 10.3390/cosmetics8040106 DOI: https://doi.org/10.3390/cosmetics8040106
39. Romes, N.B.; Abdul Wahab, R.; Abdul Hamid, M. The Role of Bioactive Phytoconstituents-Loaded Nanoemulsions for Skin Improvement: A Review. Biotechnol. Biotechnol. Equip. 2021, 35, 711–729. DOI: 10.1080/13102818.2021.1915869 DOI: https://doi.org/10.1080/13102818.2021.1915869
40. Prasanth, B.; Theertha, S.V.; Krishnakumar, K.; Neghla, E.N.; Riyamol, V.L. Design and Development of Anti-Inflammatory Cream from Prepared Medicated Oil of Moringa oleifera. Int. J. Pharm. Sci. 2025, 3, 1956–1963. DOI: 10.5281/zenodo.14723218
41. Arianto, A.; Cindy, C. Preparation and Evaluation of Sunflower Oil Nanoemulsion as a Sunscreen. Open Access Maced. J. Med. Sci. 2019, 7, 3757–3761. DOI: 10.3889/oamjms.2019.497 DOI: https://doi.org/10.3889/oamjms.2019.497
42. Banerjee, K.; Thiagarajan, N.; Thiagarajan, P. Formulation and Characterization of a Helianthus annuus–Alkyl Polyglucoside Emulsion Cream for Topical Applications. J. Cosmet. Dermatol. 2019, 18, 628–637. DOI: 10.1111/jocd.12756
43. Hwang, E.; Gao, W.; Xiao, Y.K.; Ngo, H.T.T.; Yi, T.H. Helianthus annuus L. Flower Prevents UVB-Induced Photodamage in Human Dermal Fibroblasts by Regulating the MAPK/AP-1, NFAT, and Nrf2 Signaling Pathways. J. Cell. Biochem. 2019, 120, 601–612. DOI: 10.1002/jcb.27417 DOI: https://doi.org/10.1002/jcb.27417
44. Salem, M.A.; Manaa, E.G.; Osama, N.; Aborehab, N.M.; Ragab, M.F.; Haggag, Y.A.; Ibrahim, M.T.; Hamdan, D.I. Coriander (Coriandrum sativum L.) Essential Oil and Oil-Loaded Nano-Formulations as an Anti-Aging Potentiality via TGFβ/SMAD Pathway. Sci. Rep. 2022, 12, Art. No: 10494. DOI: 10.1038/s41598-022-10494-4 DOI: https://doi.org/10.1038/s41598-022-10494-4
45. Hwang, E.; Lee, D.G.; Park, S.H.; Oh, M.S.; Kim, S.Y. Coriander Leaf Extract Exerts Antioxidant Activity and Protects Against UVB-Induced Photoaging of Skin by Regulation of Procollagen Type I and MMP-1 Expression. J. Med. Food 2014, 17, 985–995. DOI: 10.1089/jmf.2013.2999 DOI: https://doi.org/10.1089/jmf.2013.2999
46. Kumar, B.; Khan, S.A.; Akhtar, M.J. Phytochemicals and Therapeutic Potential of Punica granatum L. In Herbs, Spices and Their Roles in Nutraceuticals and Functional Foods; Elsevier: Amsterdam, The Netherlands, 2023; pp. 171–209. DOI: 10.1016/B978-0-323-90794-1.00018-1 DOI: https://doi.org/10.1016/B978-0-323-90794-1.00018-1
47. Abdellatif, A.A.H.; Alawadh, S.H.; Bouazzaoui, A.; Alhowail, A.H.; Mohammed, H.A. Anthocyanins Rich Pomegranate Cream as a Topical Formulation with Anti-Aging Activity. J. Dermatolog. Treat. 2021, 32, 983–990. DOI: 10.1080/09546634.2020.1721418 DOI: https://doi.org/10.1080/09546634.2020.1721418
48. Lee, D.G.; Park, K.; Park, H.R.; Sung, M.S.; Choi, B.R. In Vitro Anti-Skin-Aging Effects of Dried Pomegranate Concentrated Powder. Soc. Prev. Korean Med. 2018, 22, 109–123. DOI: 10.25153/spkom.2018.22.2.009 DOI: https://doi.org/10.25153/spkom.2018.22.2.009
49. Bangar, S.B.; Misal, D.B.; Gaikwad, S.S.; Masal, A.S.; Lad, S.S.; Bayaskar, P.G.; Patil, S.D. A Comprehensive Review on Phytochemical and Medicinal Properties of Tagetes erecta (Marigold). Int. J. Pharm. Res. Appl. 2025, 10, 514–524. DOI: 10.35629/4494-1001514524 DOI: https://doi.org/10.35629/4494-1001514524
50. Poonsri, O.; Kwanhian, W.; Poltien, A.; Tangteerawatana, P.; Tangpong, J. Nanoemulsion Containing SangYod Rice Bran Oil and Thanakha Extracts: In Vitro Antioxidant and Irritation Assessments. Appl. Mech. Mater. 2017, 866, 3–7. DOI: 10.4028/www.scientific.net/amm.866.3 DOI: https://doi.org/10.4028/www.scientific.net/AMM.866.3
51. Ha, S.J.; Park, J.; Lee, J.; Song, K.M.; Um, M.Y.; Cho, S.; Jung, S.K. Rice Bran Supplement Prevents UVB-Induced Skin Photoaging in Vivo. Biosci. Biotechnol. Biochem. 2018, 82, 320–328. DOI: 10.1080/09168451.2017.1417021 DOI: https://doi.org/10.1080/09168451.2017.1417021
52. Bernardi, D.S.; Pereira, T.A.; Maciel, N.R.; Bortoloto, J.; Viera, G.S.; Oliveira, G.C.; Rocha-Filho, P.A. Formation and Stability of Oil-in-Water Nanoemulsions Containing Rice Bran Oil: In Vitro and in Vivo Assessments. J. Nanobiotechnol. 2011, 9, Art. No: 44. DOI: 10.1186/1477-3155-9-44 DOI: https://doi.org/10.1186/1477-3155-9-44
53. Sandhir, R.; Khurana, M.; Kumar, N. Potential Benefits of Phytochemicals from Azadirachta indica against Neurological Disorders. Neurochem. Int. 2021, 146, Art. No: 105023. DOI: 10.1016/j.neuint.2021.105023 DOI: https://doi.org/10.1016/j.neuint.2021.105023
54. Ngo, H.T.T.; Hwang, E.; Seo, S.A.; Park, B.; Sun, Z.; Zhang, M.; Shin, Y.K.; Yi, T.H. Topical Application of Neem Leaves Prevents Wrinkle Formation in UVB-Exposed Hairless Mice. J. Photochem. Photobiol. B Biol. 2017, 169, 161–170. DOI: 10.1016/j.jphotobiol.2017.03.010 DOI: https://doi.org/10.1016/j.jphotobiol.2017.03.010
55. Tan, P.L.; Rajagopal, M.; Chinnappan, S.; Selvaraja, M.; Leong, M.Y.; Tan, L.F.; Yap, V.L. Formulation and Physicochemical Evaluation of Green Cosmeceutical Herbal Face Cream Containing Standardized Mangosteen Peel Extract. Cosmetics 2022, 9, Art. No: 46. DOI: 10.3390/cosmetics9030046 DOI: https://doi.org/10.3390/cosmetics9030046
56. Widowati, W.; Ginting, C.N.; Lister, I.N.E.; Girsang, E.; Amalia, A.; Wibowo, S.H.B.; Kusuma, H.; Rizal, R. Anti-Aging Effects of Mangosteen Peel Extract and Its Phytochemical Compounds: Antioxidant Activity, Enzyme Inhibition and Molecular Docking Simulation. Trop. Life Sci. Res. 2020, 31, 127–144. DOI: 10.21315/tlsr2020.31.3.9 DOI: https://doi.org/10.21315/tlsr2020.31.3.9
57. Sari, T.P.; Mann, B.; Kumar, R.; Singh, R.R.B.; Sharma, R.; Bhardwaj, M.; Athira, S. Preparation and Characterization of Nanoemulsion Encapsulating Curcumin. Food Hydrocoll. 2015, 43, 540–546. DOI: 10.1016/j.foodhyd.2014.07.011 DOI: https://doi.org/10.1016/j.foodhyd.2014.07.011
58. Abdellatif, A.A.H.; Mohammed, H.A.; Al-Khalaf, A.M.; Khan, O.; Mostafa, M.A.H.; Al Haidari, R.A.; Taha, H.H.; Khan, R.A. Ginkgo Biloba Leaves Extract’s Cosmeceutical Evaluation: A Preliminary Assessment on Human Volunteers towards Achieving Improved Skin Condition and Rejuvenation. Drug Dev. Ind. Pharm. 2023, 49, 281–292. DOI: 10.1080/03639045.2023.2204374 DOI: https://doi.org/10.1080/03639045.2023.2204374
59. Rattanachitthawat, N.; Rattanachitthawat, S.; Peerakam, N. Anti-Wrinkle Activity of Clausena harmandiana Essential Oil and Development of a Bioactive Nano-Drug Delivery System for Cosmetic Applications. Pharmacogn. J. 2022, 14, 416–422. DOI: 10.5530/pj.2022.14.116 DOI: https://doi.org/10.5530/pj.2022.14.116
60. Deng, R.; Xie, Y.; Chan, U.; Xu, T.; Huang, Y. Biomaterials and Biotechnology for Periodontal Tissue Regeneration: Recent Advances and Perspectives. J. Dent. Res. Dent. Clin. Dent. Prospects 2022, 16, 1–10. DOI: 10.34172/joddd.2022.001 DOI: https://doi.org/10.34172/joddd.2022.001
61. Gonnet, J.; Meriaux, C.; Poncelet, L.; Goncalves, E.; Soria, A.; Boccara, D.; Tchitchek, N.; Weiss, L.; Vogt, A.; Pedruzzi, E.; Bonduelle, O.; Hamm, G.; Ait-Belkacem, R.; Fournier, I.; Stauber, J.; Wisztorski, M.; Combadiere, B. Identification of Biomarkers of Early Innate Events during Skin Reaction Following Intradermal Injection. J. Investig. Dermatol. 2019, 139, S118. DOI: 10.1016/j.jid.2019.03.764 DOI: https://doi.org/10.1016/j.jid.2019.03.764
62. Fehér, P.; Vecsernyés, M.; Fenyvesi, F.; Váradi, J.; Kiss, T. Topical Application of Silybum marianum Extract. Arad Med. J. 2011, 14, 5–8.
63. Turcov, D.; Trifan, A.; Puitel, A.C.; Cimpoesu, R.; Zbranca-Toporas, A.; Maxim, C.; Suteu, D.; Barna, A.S. Preliminary Studies about Valorization of Acmella oleracea Bioactive Content in Modern Dermato-Cosmetic Applications to Combat Skin Oxidative Stress. Int. J. Mol. Sci. 2024, 25, Art. No: 8886. DOI: 10.3390/ijms25168886 DOI: https://doi.org/10.3390/ijms25168886
64. Savic, S.M.; Cekic, N.D.; Savic, S.R.; Ilic, T.M.; Savic, S.D. ‘All-Natural’ Anti-Wrinkle Emulsion Serum with Acmella oleracea Extract: A Design of Experiments (DoE) Formulation Approach, Rheology and in Vivo Skin Performance/Efficacy Evaluation. Int. J. Cosmet. Sci. 2021, 43, 530–546. DOI: 10.1111/ics.12726 DOI: https://doi.org/10.1111/ics.12726
65. Apraj, V.D.; Pandita, N.S. Evaluation of Skin Anti-Aging Potential of Citrus reticulata Blanco Peel. Pharmacogn. Res. 2016, 8, 160–168. DOI: 10.4103/0974-8490.182913 DOI: https://doi.org/10.4103/0974-8490.182913
66. Berawi, K.N.; Surbakti, E.S.B. Tomat (Lycopersicum esculentum Mill.) Sebagai Anti Penuaan Kulit. J. Major 2016, 5, 73–78.
67. Chatarina, M.; Hastiningsih, I. Formulation of Antiaging Activities in Creams Made from Natural Active Ingredients. J. EduHealt. 2024, 15, 798–811. DOI: 10.54209/eduhealth.v15i02
68. Lee, H.Y.; Ghimeray, A.K.; Yim, J.H.; Chang, M.S. Antioxidant, Collagen Synthesis Activity in Vitro and Clinical Test on Anti-Wrinkle Activity of Formulated Cream Containing Veronica officinalis Extract. J. Cosmet. Dermatol. Sci. Appl. 2015, 5, 45–51. DOI: 10.4236/jcdsa.2015.51006 DOI: https://doi.org/10.4236/jcdsa.2015.51006
69. Srisuksomwong, P.; Kaenhin, L.; Mungmai, L. Collagenase and Tyrosinase Inhibitory Activities and Stability of Facial Cream Formulation Containing Cashew Leaf Extract. Cosmetics 2023, 10, Art. No: 17. DOI: 10.3390/cosmetics10010017 DOI: https://doi.org/10.3390/cosmetics10010017
70. Cefali, L.C.; Vazquez, C.; Ataide, J.A.; Figueiredo, M.C.; Ruiz, A.L.T.G.; Foglio, M.A.; Lancellotti, M.; Mazzola, P.G. In Vitro Activity and Formulation of a Flavonoid-Containing Cashew Pulp Extract for the Topical Treatment of Acne and the Protection of Skin against Premature Aging. Nat. Prod. Res. 2021, 35, 5243–5249. DOI: 10.1080/14786419.2020.1747454 DOI: https://doi.org/10.1080/14786419.2020.1747454
71. Garg, C.; Khurana, P.; Garg, M. Antiaging and Antiwrinkle Potential of Glycyrrhiza glabra. Plant Arch. 2019, 19, 1151–1155.
72. Shahane, K.; Kshirsagar, M.; Tambe, S.; Jain, D.; Rout, S.; Ferreira, M.K.M.; Mali, S.; Amin, P.; Srivastav, P.P.; Cruz, J.; Lima, R.R. An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L. Pharmaceuticals 2023, 16, Art. No: 611. DOI: 10.3390/ph16040611 DOI: https://doi.org/10.3390/ph16040611
73. Alnuqaydan, A.M.; Sanderson, B.J. Calendula officinalis Protection Against Cytotoxicity Effects of Personal Care Products on HaCaT Human Skin Cells. J. Clin. Toxicol. 2016, 6, Art. No: 1000316. DOI: 10.4172/2161-0495.1000316 DOI: https://doi.org/10.4172/2161-0495.1000316
74. Akhtar, N.; Zaman, S.U.; Khan, B.A.; Amir, M.N.; Ebrahimzadeh, M.A. Calendula Extract: Effects on Mechanical Parameters of Human Skin. Acta Pol. Pharm. 2011, 68, 693–701.
75. Han, H.J. Development of an Effective Formulation for an Acne Treatment Cream with Ocimum basilicum Using Invasomes. J. Cosmet. Med. 2018, 2, 69–75. DOI: 10.25056/JCM.2018.2.2.69 DOI: https://doi.org/10.25056/JCM.2018.2.2.69
76. Shahrajabian, M.H.; Sun, W.; Cheng, Q. Chemical Components and Pharmacological Benefits of Basil (Ocimum basilicum): A Review. Int. J. Food Prop. 2020, 23, 1961–1970. DOI: 10.1080/10942912.2020.1828456 DOI: https://doi.org/10.1080/10942912.2020.1828456
77. Mechchate, H.; Es-Safi, I.; Amaghnouje, A.; Boukhira, S.; Alotaibi, A.A.; Al-Zharani, M.; Nasr, F.A.; Noman, O.M.; Conte, R.; Amal, E.H.E.Y.; Bekkari, H.; Bousta, D. Antioxidant, Anti-Inflammatory and Antidiabetic Properties of LC-MS/MS Identified Polyphenols from Coriander Seeds. Molecules 2021, 26, Art. No: 487. DOI: 10.3390/molecules26020487 DOI: https://doi.org/10.3390/molecules26020487
78. Jeya, K.; Veerapagu, M.; Sangeetha, V. Antimicrobial and Antioxidant Properties of Coriandrum sativum L. Seed Essential Oil. Am. J. Essent. Oils Nat. Prod. 2019, 7, 6–10.
79. Bito, T.; Nishigori, C. Impact of Reactive Oxygen Species on Keratinocyte Signaling Pathways. J. Dermatol. Sci. 2012, 68, 3–8. DOI: 10.1016/j.jdermsci.2012.06.006 DOI: https://doi.org/10.1016/j.jdermsci.2012.06.006
80. Baccarin, T.; Lemos-Senna, E. Potential Application of Nanoemulsions for Skin Delivery of Pomegranate Peel Polyphenols. AAPS PharmSciTech 2017, 18, 3307–3314. DOI: 10.1208/s12249-017-0818-x DOI: https://doi.org/10.1208/s12249-017-0818-x
81. Souto, E.B.; Cano, A.; Martins-Gomes, C.; Coutinho, T.E.; Zielińska, A.; Silva, A.M. Microemulsions and Nanoemulsions in Skin Drug Delivery. Bioengineering 2022, 9, Art. No: 158. DOI: 10.3390/bioengineering9040158 DOI: https://doi.org/10.3390/bioengineering9040158
82. Kang, C.H.; Rhie, S.J.; Kim, Y.C. Antioxidant and Skin Anti-Aging Effects of Marigold Methanol Extract. Toxicol. Res. 2018, 34, 31–39. DOI: 10.5487/TR.2018.34.1.031 DOI: https://doi.org/10.5487/TR.2018.34.1.031
83. Leelapornpisid, P.; Kiattisin, K.; Jantrawut, P.; Phrutivorapongkul, A. Nanoemulsion Loaded with Marigold Flower Extract (Tagetes erecta Linn) in Gel Preparation as Anti-Wrinkles Cosmeceutical. Int. J. Pharm. Pharm. Sci. 2014, 6, 231–236.
84. Rinaldi, F.; Hanieh, P.N.; Longhi, C.; Carradori, S.; Secci, D.; Zengin, G.; Ammendolia, M.G.; Mattia, E.; Del Favero, E.; Marianecci, C.; Carafa, M. Neem Oil Nanoemulsions: Characterisation and Antioxidant Activity. J. Enzyme Inhib. Med. Chem. 2017, 32, 1265–1273. DOI: 10.1080/14756366.2017.1378190 DOI: https://doi.org/10.1080/14756366.2017.1378190
85. Saraf, S.; Jeswani, G.; Kaur, C.D.; Saraf, S. Development of Novel Herbal Cosmetic Cream with Curcuma longa Extract Loaded Transfersomes for Antiwrinkle Effect. Afr. J. Pharm. Pharmacol. 2011, 5, 1054–1062.
86. Kim, D.; Hwang, I.; Ku, B.; Choi, E.M. Antioxidant and Skin Anti-Aging Effects of the Aqueous Ethanol Extract of Ginkgo biloba Leaf: An in Vitro Study Using HaCaT Keratinocytes. Toxicol. Environ. Health Sci. 2021, 13, 133–142. DOI: 10.1007/s13530-021-00088-4 DOI: https://doi.org/10.1007/s13530-021-00088-4
87. Tanruean, K.; Poolprasert, P.; Suwannarach, N.; Kumla, J.; Lumyong, S. Phytochemical Analysis and Evaluation of Antioxidant and Biological Activities of Extracts from Three Clauseneae Plants in Northern Thailand. Plants 2021, 10, Art. No: 17. DOI: 10.3390/plants10010117 DOI: https://doi.org/10.3390/plants10010117
88. Ekiert, H.; Klimek-Szczykutowicz, M.; Rzepiela, A.; Klin, P.; Szopa, A. Artemisia Species with High Biological Values as a Potential Source of Medicinal and Cosmetic Raw Materials. Molecules 2022, 27, Art. No: 6427. DOI: 10.3390/molecules27196427 DOI: https://doi.org/10.3390/molecules27196427
89. Hahn, H.J.; Jung, H.J.; Schrammek-Drusios, M.C.; Lee, S.N.; Kim, J.H.; Kwon, S.B.; An, I.S.; An, S.; Ahn, K.J. Instrumental Evaluation of Anti-Aging Effects of Cosmetic Formulations Containing Palmitoyl Peptides, Silybum marianum Seed Oil, Vitamin E and Other Functional Ingredients on Aged Human Skin. Exp. Ther. Med. 2016, 12, 1171–1176. DOI: 10.3892/etm.2016.3447 DOI: https://doi.org/10.3892/etm.2016.3447
90. Kowalczyk, S.; Grymel, M.; Bilik, J.; Kula, W.; Wawoczny, A.; Grymel, P.; Gillner, D. Selected Plants as Sources of Natural and Active Ingredients for Cosmetics of the Future. Appl. Sci. 2024, 14, Art. No: 3487. DOI: 10.3390/app14083487 DOI: https://doi.org/10.3390/app14083487
91. Addi, M.; Elbouzidi, A.; Abid, M.; Tungmunnithum, D.; Elamrani, A.; Hano, C. An Overview of Bioactive Flavonoids from Citrus Fruits. Appl. Sci. 2022, 12, Art. No: 29. DOI: 10.3390/app12010029 DOI: https://doi.org/10.3390/app12010029
92. Somwanshi, S.B.; Kudale, K.S.; Dolas, R.T.; Kotade, K.B. Formulation and Evaluation of Cosmetic Herbal Face Pack for Glowing Skin. Int. J. Res. Ayurveda Pharm. 2017, 8, 199–203. DOI: 10.7897/2277-4343.083199 DOI: https://doi.org/10.7897/2277-4343.083199
93. Wuttisin, N.; Boonmak, J.; Thaipitak, V.; Thitilertdecha, N.; Kittigowittana, K. Anti-Tyrosinase Activity of Orange Peel Extract and Cosmetic Formulation. Int. Food Res. J. 2017, 24, 2128–2132.
94. Zhang, S.; Lu, S.; Wang, Y.; Ni, J.; Xiao, G. The Efficacy of a Novel Tomato Extracts Formulation on Skin Aging and Pigmentation: A Randomized, Double-Blind, Parallel-Controlled Trial. J. Dermatol. Sci. Cosmet. Technol. 2024, 1, Art. No: 100005. DOI: 10.1016/j.jdsct.2024.100005 DOI: https://doi.org/10.1016/j.jdsct.2024.100005
95. Jaradat, N.A.; Zaid, A.N.; Hussen, F.; Issa, L.; Altamimi, M.; Fuqaha, B.; Nawahda, A.; Assadi, M. Phytoconstituents, Antioxidant, Sun Protection and Skin Anti-Wrinkle Effects Using Four Solvent Fractions of the Root Bark of the Traditional Plant Alkanna tinctoria (L.). Eur. J. Integr. Med. 2018, 21, 88–93. DOI: 10.1016/j.eujim.2018.07.003 DOI: https://doi.org/10.1016/j.eujim.2018.07.003
96. Dorni, A.I.C.; Amalraj, A.; Gopi, S.; Varma, K.; Anjana, S.N. Novel Cosmeceuticals from Plants—An Industry Guided Review. J. Appl. Res. Med. Aromat. Plants 2017, 7, 1–26. DOI: 10.1016/j.jarmap.2017.05.003 DOI: https://doi.org/10.1016/j.jarmap.2017.05.003
97. Xue, F.; Li, X.; Qin, L.; Liu, X.; Li, C.; Adhikari, B. Anti-Aging Properties of Phytoconstituents and Phyto-Nanoemulsions and Their Application in Managing Aging-Related Diseases. Adv. Drug Deliv. Rev. 2021, 176, Art. No: 113886. DOI: 10.1016/j.addr.2021.113886 DOI: https://doi.org/10.1016/j.addr.2021.113886
98. Laribi, B.; Kouki, K.; M’Hamdi, M.; Bettaieb, T. Coriander (Coriandrum sativum L.) and Its Bioactive Constituents. Fitoterapia 2015, 103, 9–26. DOI: 10.1016/j.fitote.2015.03.012 DOI: https://doi.org/10.1016/j.fitote.2015.03.012
99. Achagar, R.; Ait-Touchente, Z.; El Ati, R.; Boujdi, K.; Thoume, A.; Abdou, A.; Touzani, R. A Comprehensive Review of Essential Oil–Nanotechnology Synergy for Advanced Dermocosmetic Delivery. Cosmetics 2024, 11, Art. No: 48. DOI: 10.3390/cosmetics11020048 DOI: https://doi.org/10.3390/cosmetics11020048
100. Banerjee, K.; Thiagarajan, N.; Thiagarajan, P. Formulation and Characterization of a Helianthus annuus–Alkyl Polyglucoside Emulsion Cream for Topical Applications. J. Cosmet. Dermatol. 2019, 18, 628–637. DOI: 10.1111/jocd.12756 DOI: https://doi.org/10.1111/jocd.12756
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Arun Kumar, DR. Mayur Porwal, DR. Vaibhav Rastogi
This work is licensed under a Creative Commons Attribution 4.0 International License.
For all articles published in Prospects in Pharmaceutical Sciences copyright is retained by the authors. The journal publishes articles in the Open Access policy, within the CC BY 4.0 licence.
This is a human-readable summary of (and not a substitute for) the license. Disclaimer.
You are free to:
Share — copy and redistribute the material in any medium or format
Adapt — remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.
How to Cite
