SELENINOTRIGLICERYDY NADZIEJĄ W ZWALCZANIU NOWOTWORÓW

Anna Flis-Borsuk; Lidia Śliwka; Zofia Suchocka; Jakub Borsuk; Zbigniew Fijałek; Katarzyna Lubelska; Piotr Suchocki

doi:10.56782/pps.105

Published : 2016-05-25

Vol. 14 No. 3 (2016)

SELENITETRIGLYCERIDES AND THEIR PROMISE IN CANCER TREATMENT

Anna Flis-Borsuk

Lidia Śliwka

Zofia Suchocka

Jakub Borsuk

Zbigniew Fijałek

Katarzyna Lubelska

Piotr Suchocki

DOI: https://doi.org/10.56782/pps.105

Abstract

Selol is a mixture of selenitetriglycerides, which are unique selenium compounds at the +4 oxidation state. In vitro and in vivo studies have shed light on mechanisms essential for the understanding of the biomedical actions of Selol in health and disease. Following administration, Selol has an initial strong pro-oxidative and antineoplastic effect, while in the second phase it exhibits antioxidant and repair properties. Selol is a promising pharmacological agent with antioxidant, anti-inflammatory, neuroprotective and anti-mutagenic properties. Preclinical studies of Selol are currently nearing completion. Non-commercial clinical pilot studies are in progress, and are based on the biological activity profile of Selol. This review summarizes the current knowledge of the biochemical and molecular properties of Selol and outlines future directions in this area of research.

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Flis-Borsuk, A., Śliwka, L., Suchocka, Z., Borsuk, J., Fijałek, Z., Lubelska, K., & Suchocki, P. (2016). SELENITETRIGLYCERIDES AND THEIR PROMISE IN CANCER TREATMENT. Prospects in Pharmaceutical Sciences, 14(3), 17–24. https://doi.org/10.56782/pps.105

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