OCHRONNA ROLA KWASU α-LIPONOWEGO W MIAŻDŻYCY I CHOROBACH SERCOWO-NACZYNIOWYCH

Dominika Łacheta; Wioletta Olejarz

doi:10.56782/pps.24

Data publikacji : 2019-08-07

Tom 17 Nr 8 (2019)

PROTECTIVE ROLE OF α-LIPOIC ACID IN ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES

Dominika Łacheta

Wioletta Olejarz

DOI: https://doi.org/10.56782/pps.24

Abstrakt

α-lipoic acid (α-LA) is a natural antioxidant found in food as a lipolysin. Both α-LA and its reduced form DHLA (dihydrolipoic acid) inhibit the production of reactive oxygen species (ROS) and reduce their harmful effects, as well as have the ability to chelate transition metals and regenerate other antioxidants. In addition to the antioxidant effect, they also have anti-inflammatory impact. Oxidative stress and inflammation play a key role in the pathogenesis of atherosclerosis and cardiovascular diseases. α-LA reduces the level of lipids in the blood, prevents oxidative modifications of the LDL molecule and inhibits the formation of atherosclerotic plaque. The nuclear factor κB (NF-κB) contributes to the development of atherosclerosis by activating proinflammatory genes, and α-LA inhibits the inflammatory response induced by NF-κB by reducing oxidative stress, inhibiting the expression of adhesion molecules and the proliferation and migration of vascular smooth muscle cells. Also, α-LA supplementation can lower blood pressure. The paper reviews the researches on the role of α-LA in the pathogenesis of atherosclerosis and cardiovascular diseases.

Słowa kluczowe:

α-lipoic acid, antioxidant, atherosclerosis, cardiovascular diseases

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Łacheta, D., & Olejarz, W. (2019). PROTECTIVE ROLE OF α-LIPOIC ACID IN ATHEROSCLEROSIS AND CARDIOVASCULAR DISEASES. Prospects in Pharmaceutical Sciences, 17(8), 43–50. https://doi.org/10.56782/pps.24

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Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substratebinding affinity and activity in brain by feeding old rats acetyl-Lcarnitine and/or R-alpha -lipoic acid. Proc Natl Acad Sci U S A.

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Dominika Łacheta

dominika.lacheta@wum.edu.pl

Afiliacja:

Katedra Biochemii i Chemii Klinicznej, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej oraz Centrum Badań Przedklinicznych, Warszawski Uniwersytet Medyczny, ul. Banacha 1, 02-097 Warszawa Poland

Wioletta Olejarz

Afiliacja: